Molecular Biology of the Gene

The classic textbook in molecular biology, updated with new chapters, new information, and new media.

 

Completely up-to-date with the latest research advances, the Sixth Edition of James D. Watsons classic text, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology. Twenty-two concise chapters, co-authored by six highly respected biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.

 

Two new chapters discuss the emerging research fields of Regulatory RNAs (Chapter 18) and Genomics and Systems Biology (Chapter 20), and give particular focus on RNAi, microRNAs, the opportunities offered by the new generation of genome technologies, and the elucidation of gene regulatory networks. 

 

Every chapter includes thorough content updates, and where relevant, the inclusion of medical insights that have emerged from our understanding of basic molecular biology, and references that direct students to explore the expanded companion website. 

(Pearson)

Bli först med att recensera och betygsätt boken Molecular Biology of the Gene - du kan vinna 200 kr varje månad i tävlingen "Månadens recension".

James D. Watson was Director of Cold Spring Harbor Laboratory from 1968 to 1993, President from 1994 to 2003, and is now its Chancellor. He spent his undergraduate years at the University of Chicago and received his Ph.D. in 1950 from Indiana University. Between 1950 and 1953, he did postdoctoral research in Copenhagen and Cambridge, England. While at Cambridge, he began the collaboration that resulted in the elucidation of the double-helical structure of DNA in 1953. (For this discovery, Watson, Francis Crick, and Maurice Wilkins were awarded the Nobel Prize in 1962.) Later in 1953, he went to the California Institute of Technology. He moved to Harvard in 1955, where he taught and did research on RNA synthesis and protein synthesis until 1976. He was the first Director of the National Center for Genome Research of the National Institutes of Health from 1989 to 1992. Dr. Watson was sole author of the first, second, and third editions of Molecular Biology of the Gene, and a co-author of the fourth and fifth editions. These were published in 1965, 1970, 1976, 1987, and 2003, respectively. He is also a co-author of two other textbooks: Molecular Biology of the Cell and Recombinant DNA. Tania A. Baker is the Whitehead Professor of Biology at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. She received a B.S. in biochemistry from the University of Wisconsin, Madison, and a Ph.D. in biochemistry from Stanford University in 1988. Her graduate research was carried out in the laboratory of Professor Arthur Kornberg and focused on mechanisms of initiation of DNA replication. She did postdoctoral research in the laboratory of Dr. Kiyoshi Mizuuchi at the National Institutes of Health, studying the mechanism and regulation of DNA transposition. Her current research explores mechanisms and regulation of genetic recombination, enzyme-catalyzed protein unfolding, and ATP-dependent protein degradation. Professor Baker received the 2001 Eli Lilly Research Award from the American Society of Microbiology and the 2000 MIT School of Science Teaching Prize for Undergraduate Education and was elected as a fellow of the American Academy of Arts and Sciences in 2004. She is co-author (with Arthur Kornberg) of the book DNA Replication, Second Edition. Stephen P. Bell is a Professor of Biology at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. He received B.A. degrees from the Department of Biochemistry, Molecular Biology, and Cell Biology and the Integrated Sciences Program at Northwestern University and a Ph.D. in biochemistry at the University of California, Berkeley in 1991. His graduate research was carried out in the laboratory of Dr. Robert Tjian and focused on eukaryotic transcription. He did postdoctoral research in the laboratory of Dr. Bruce Stillman at Cold Spring Harbor Laboratory, working on the initiation of eukaryotic DNA replication. His current research focuses on the mechanisms controlling the duplication of eukaryotic chromosomes. Professor Bell received the 2001 ASBMB-Schering Plough Scientific Achievement Award, the 1998 Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching at MIT and the 2006 MIT School of Science Teaching Award. Alexander A. F. Gann is Editorial Director of Cold Spring Harbor Laboratory Press, and a faculty member of the Watson School of Biological Sciences at Cold Spring Harbor Laboratory. He received his B.Sc in microbiology from University College London and a Ph.D. in molecular biology from The University of Edinburgh in 1989. His graduate research was carried out in the laboratory of Noreen Murray and focused on DNA recognition by restriction enzymes. He did postdoctoral research in the laboratory of Mark Ptashne at Harvard, working on transcriptional regulation, and that of Jeremy Brockes at the Ludwig Institute of Cancer Research at University College London, wher

(Pearson)

PART 1  Chemistry and Genetics

1  Mendelian View of the World

2  Nucleic Acids Convey Genetic Information

3  The Importance of Weak Chemical Interactions

4  The Importance of High Energy Bonds

5  Weak and Strong Bonds Determine Macromolecular Interactions

 

PART 2  Maintenance of the Genome

6  The Structures of DNA and RNA

7  Genome Structure, Chromatin and the Nucleosome

8  DNA replication

9  The Mutability and Repair of DNA 

10  Homologous Recombination at the Molecular Level

11  Site-Specific Recombination and Transposition of DNA

 

PART 3  Expression of the Genome

12  Mechanisms of Transcription

13  Splicing

14  Translation

 

PART 4 Regulation 

15  The Genetic Code

16  Transcriptional Regulation in Prokaryotes

17  Transcriptional Regulation in Eukaryotes

18  Regulatory RNAs

19  Gene Regulation in Development and Evolution

20  Genomics and Systems Biology

 

PART 5  Methods

21  Techniques of Molecular Biology

22  Model Organisms

(Pearson)