Molecular Biology of the Cell

"Throughout the book, emphasis is placed not just on what 'we know' but also on 'how we know' and 'what remains to be discovered'- important for engaging and enthusing students....A quarter of a century after the first edition revolutionised cell biology textbooks, the new edition is as fresh, comprehensive and above all, as readable as ever....Like its predecessors, this is a superb textbook for advanced undergraduate and postgraduate students." -British Society for Developmental Biology Newsletter, Summer 2008, Vol. 29, No. 1 "Professors, lecturers, and instructors will find the fifth edition of the book Molecular Biology of the Cell and its accompanying Problems Book to be an excellent choice for guiding their students through the maze of the cell's molecular structures and biochemical processes....With countless colorful illustrations and a large number of photographs and tables, reading the text becomes not only an educational experience, but also a highly enjoyable one for those students who wish to discover the inner workings of the magnificent cellular machine....Educators will also find the DVD-ROM to be a rich electronic resource when compiling their lectures....No less important is the Problems Book, which contains numerous exercises and questions that are an integral part of the learning process, and that teachers, instructors, and students are sure to appreciate." The Quarterly Review of Biology, September 2008, Volume 83, Number 3

Bruce Alberts, University of California, San Francisco, USA Alexander Johnson, University of California, San Francisco, USA Julian Lewis, (Deceased), formerly of Cancer Research UK David Morgan, University of California, San Francisco, USA Martin Raff, University College London, UK Keith Roberts, Emeritus, University of East Anglia, UK Peter Walter, University of California, San Francisco, USA

INTRODUCTION TO THE CELL 1. Cells and Genomes 2. Cell Chemistry and Bioenergetics 3. Proteins BASIC GENETIC MECHANISMS 4. DNA, Chromosomes, and Genomes 5. DNA Replication, Repair, and Recombination 6. How Cells Read the Genome: From DNA to Protein 7. Control of Gene Expression WAYS OF WORKING WITH CELLS 8. Analyzing Cells, Molecules, and Systems 9. Visualizing Cells INTERNAL ORGANIZATION OF THE CELL 10. Membrane Structure 11. Membrane Transport of Small Molecules and the Electrical Properties of Membranes 12. Intracellular Compartments and Protein Sorting 13. Intracellular Membrane Traffic 14. Energy Conversion: Mitochondria and Chloroplasts 15. Cell Signaling 16. The Cytoskeleton 17. The Cell Cycle 18. Cell Death CELLS IN THEIR SOCIAL CONTEXT 19. Cell Junctions and the Extracellular Matrix 20. Cancer 21. Development of Multicellular Organisms 22. Stem Cells and Tissue Renewal 23. Pathogens and Infection 24. The Innate and Adaptive Immune Systems