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Presents a state-of-the-art examination of Crohn's disease (CD), from an historical evolution of the field to future developments of etiopathogenesis, diagnostic evaluation, and therapeutic management. Reviews possible etiologic agents, the various ways CD progresses, novel diagnostic techniques, and standard and innovative therapies. Emphasizes the application of recent advances in basic research to clinical management of the disease.

This up-to-the-minute reference delineates-in a systematic fashion-the appropriate, sequential steps for the formulation of safe, effective, stable, and marketable liquid parenteral biopharmaceutical products-covering fundamentals and essential pathways for each phase as well as its purpose, function, and relation to other stages in the product development process. Written by experts currently involved in state-of-the-art advances in the pharmaceutical drug industry, Development of Biopharmaceutical Parenteral Dosage Formsdetails biopharmaceuticals that are licensed or undergoing clinical development, including genetically engineered cell and engineered vectors in the fermentation process describes purification and characterization techniques for rDNA therapeutics, discussing several types of unit operations for isolation, purification, and characterization considers preformulation and formulation requirements, such as physicochemical properties, drug delivery, stability studies programs, deactivation/denaturation routes, selection of compatible excipients, and regulatory compliance elucidates basics of analytical techniques, methods development, separation methods using chromatographic and electrophoretic techniques, and bioactivity methods covering bioassays and immunoassays for quantifying the stability of biological activity shows how to select the appropriate filter for maximizing compatibility and minimizing adsorption and inactivation, examining topics from basic filtration theories to future trends reviews the selection process for compatible elastomeric closures, analyzing physical, chemical, toxicological properties, protein adsorption on elastomeric surfaces, strategies to reduce/eliminate adsorption, and specialized containers for biotechnological applications and more!Furnished with helpful references, tables, and drawings, this practical guide is indispensable

In Studies in Iconology, the themes and concepts of Renaissance art are analysed and related to both classical and medieval tendencies.

Renaissance and Renascences in Western Art spans the period from the 10th to the 15th century, including discussion of the Carolingian renaissance and the 12th century proto-renaissance. Erwin Panofsky posits that there were "reanscences" prior to the widely known Renaissance that began in Italy in the 14th century. Whereas earlier renascences can be classified as revivals, the Renaissance was a unique instance that led to a wider cultural transformation.

This is a nonchronological introduction to Baroque, one of the great periods of European art. John Martin's descriptions of the essential characteristics of the Baroque help one to gain an understanding of the style. His illustrations are informative and he has clearly looked with a fresh eye at the works of art themselves. In addition to the more than 200 illustrations, the volume contains an appendix of translated documents.

The Italian Renaissance has come to occupy an almost mythical place in the popular imagination. The outsized reputations of the best-known figures from the period—Michelangelo, Niccolo Machiavelli, Lorenzo the Magnificent, Pope Julius II, Isabella d'Este, and so many others—engender a kind of wonder. How could so many geniuses or exceptional characters be produced by one small territory near the extreme south of Europe at a moment when much of the rest of the continent still labored under the restrictions of the Middle Ages? How did so many of the driving principles behind Western civilization emerge during this period—and how were they defined and developed? And why is it that geniuses such as Leonardo, Raphael, Petrarch, Brunelleschi, Bramante, and Palladio all sustain their towering authority to this day?  To answer these questions, Kenneth Bartlett delves into the lives and works of the artists, patrons, and intellectuals—the privileged, educated, influential elites—who created a rarefied world of power, money, and sophisticated talent in which individual curiosity and skill were prized above all else. The result is a dynamic, highly readable, copiously illustrated history of the Renaissance in Italy—and of the artists that gave birth to some of the most enduring ideas and artifacts of Western civilization.

The Italian Renaissance has come to occupy an almost mythical place in the popular imagination. The outsized reputations of the best-known figures from the period—Michelangelo, Niccolo Machiavelli, Lorenzo the Magnificent, Pope Julius II, Isabella d'Este, and so many others—engender a kind of wonder. How could so many geniuses or exceptional characters be produced by one small territory near the extreme south of Europe at a moment when much of the rest of the continent still labored under the restrictions of the Middle Ages? How did so many of the driving principles behind Western civilization emerge during this period—and how were they defined and developed? And why is it that geniuses such as Leonardo, Raphael, Petrarch, Brunelleschi, Bramante, and Palladio all sustain their towering authority to this day?  To answer these questions, Kenneth Bartlett delves into the lives and works of the artists, patrons, and intellectuals—the privileged, educated, influential elites—who created a rarefied world of power, money, and sophisticated talent in which individual curiosity and skill were prized above all else. The result is a dynamic, highly readable, copiously illustrated history of the Renaissance in Italy—and of the artists that gave birth to some of the most enduring ideas and artifacts of Western civilization.