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Das Herz-Kreislauf-Zentrum Freiburg hat in Zusammenarbeit mit der Deutschen Gesellschaft für Thorax-, Herz- und Gefäßchirurgie (DGTHG) ein neues Weiterbildungskonzept für angehende Herzchirurgen entwickelt. Das alte Prinzip des Learning by Doing, bei dem hochsensible Operationstechniken direkt am Patienten erlernt werden, wird abgelöst durch eine Kombination aus theoretischen und praktischen Lerneinheiten, die die Assistenten in Weiterbildung Schritt für Schritt durch den Operationsalltag begleiten. Das vorliegende Manual, das exakt auf das Fachgebiet zugeschnitten ist, vermittelt die dafür notwendigen Kenntnisse, und das dazugehörige Logbuch ermöglicht die Prüfung der Lerninhalte und die Dokumentation des Lernerfolgs. Assistenten in Weiterbildung erhalten dank dieses Konzepts nicht nur eine klar strukturierte Ausbildung, sondern sie erwerben über die kontinuierlich zu sammelnden Leistungsbelege auch einen eindeutigen Nachweis ihrer Fähigkeiten und Kompetenzen auf dem Weg zur Facharztreife. Der jeweilige Ausbildungsstand kann objektiv geprüft und Defizite können rasch erkannt und behoben werden. Nicht nur Lernende und Lehrende sondern alle in der Herz- und Gefäßchirurgie tätigen Ärzte profitieren von diesem Konzept. Zusätzlich werden auf der Karger Homepage kurze Videosequenzen zu finden sein, die viele der im Buch beschriebenen Techniken veranschaulichen. QR-Codes in den einzelnen Kapiteln werden den entsprechenden Zugang direkt ermöglichen.

Ten years ago a group of experts assembled in Chicago to develop a consensus on the management of conditions previously described as intersex. The consequences of this consensus have been far reaching, including a change in nomenclature, the development of greater collaboration across geographical boundaries, and a move towards greater involvement of patients and parents. Moreover, an international registry was established, as well as research and clinical networks. This book brings together a thorough overview on all these topics. Furthermore, the major technological advances in diagnostic genetic and biochemical capabilities over the past 10 years are outlined in detail. Offering a comprehensive update on various aspects of disorders of sex development (DSD), this book will be essential reading to all clinicians who are involved in delivering health care to patients with a DSD, as well as scientists involved in biomedical research related to DSD.

Neuroblastoma is the most common extracranial solid tumor in children, with the highest incidence in children aged under 5 years. 'Fast Facts: Neuroblastoma' reviews the epidemiology and what is understood thus far about the pathogenesis of neuroblastoma. The book then dives into the various ways in which neuroblastoma may present and outlines the diagnostic studies needed to complete workup. It includes both a review of prognostic factors and disease risk stratification, and a comprehensive overview of treatment regimens for low-, intermediate- and high-risk disease.

Prostate cancer is the second most common cancer in men worldwide, but it is unusual among solid tumors in that many men die with, rather than of, the disease. This raises challenges in terms of deciding if, when, and how to intervene to control tumor growth and spread inorder to extend survival without compromising quality of life. The many developments in the field since the last edition of this book include continuing studies to improve detection and monitoring of the disease, with the evaluation of MRI for screening and prostate-specific membrane antigen (PSMA)-PET/CT for staging. Treatment options have also continued to improve and expand for all stages of the disease with the development of ultrahypofractionated radiotherapy, oral LHRH antagonists, PARP inhibitors and lutetium-177 PSMA-617 radioligand therapy.

The book comprehensively discusses Molar Incisor Hypomineralisation (MIH), exploring whether it is a recent phenomenon or a newly recognized issue. It details developmental defects of enamel and the clinical characteristics of hypomineralised enamel. The book addresses the challenges of using scoring systems for MIH assessment and emphasizes the importance of comprehensive patient evaluation, including oral clinical records and behavior assessment. The impact of MIH on quality of life is discussed, alongside the post-eruptive breakdown of demarcated opacities. The prevalence and distribution of MIH and deciduous tooth hypomineralisation are covered, along with systemic and environmental risk factors and genetic theories. The book also addresses hypersensitivity and its management. It questions whether MIH is a risk factor for dental caries and if it is possible to remineralise hypomineralised enamel. The use of fissure sealants for managing hypersensitivity and post-eruptive breakdown in MIH-affected molars is discussed, along with adhesive challenges, esthetic restoration, and restorative possibilities for severely affected molars. Finally, the book highlights the rationale behind the extraction of hypomineralised first molars, the cost-effectiveness of MIH management, and the role of the internet in obtaining and sharing MIH-related information.

Pyruvate kinase deficiency (PK deficiency) is a rare genetic disease that causes red blood cells to break apart easily (hemolysis). Some patients have no or few symptoms; others have very low numbers of red blood cells (hemolytic anemia) and need treatment with regular blood transfusions. Hemolysis occurs in everyone with PK deficiency. It increases the risk of complications that need monitoring, such as gallstones, iron overload, and low bone density. Treatment with mitapivat, which is taken as a tablet, activates pyruvate kinase and reduces anemia and hemolysis in about half of all adults with PK deficiency. Research into other new treatments, including gene therapy, is promising. Common supportive treatments include blood transfusions, removal of the spleen (splenectomy), and medications to remove excess iron from the blood (chelation therapy).

'Fast Facts: Síndromes talasémicos' proporciona una introduccióndetallada y concisa a los síndromes talasémicos y a los enfoquesactuales para su tratamiento y el de las enfermedades asociadas.También ofrece información sobre algunos de los nuevos tratamientosque se cuentran actualmente en fase de estudio en ensayos clínicoso que se han aprobado recientemente, y quepueden tener el potencial de transformar la vida de los pacientes contalasemia.

'Fast Facts: Sindromi talassemiche' offre una presentazione concisa e completa delle sindromi talassemiche e delle opzioni attualmente disponibili per il trattamento delle talassemie e delle comorbidità associate. Inoltre, fornisce informazioni su alcune nuove terapie attualmente oggetto di studi clinici o approvate recentemente, potenzialmente in grado di cambiare la vita dei pazienti talassemici.

It is more important than ever to consider trends in nutrition across the world, especially after the COVID-19 pandemic highlighted the wide discrepancies in access to healthcare, good nutrition, and health outcomes. The 98th Nestlé Nutrition Institute Workshop was delivered in October 2022 in collaboration with the International Academy of Nutritional Educators and NNedPro Global Institute for Food, Nutrition and Health, and focussed on the personal and research experiences of the speakers. Speakers included international leaders in nutrition throughout the lifespan, with a focus on optimising dietary quality to promote health and wellbeing. Good nutrition is vital in the first 1,000 days of life, particularly for shaping immune responses but this extends through to much later in life, when appropriate nutritional support can help keep vulnerable people out of hospital and living independently at home. The pandemic also made us take stock of the burden of malnutrition, both over and under nutrition, and health inequalities worldwide. This multidisciplinary workshop provided a platform to reflect on, and discuss what we have learned previously, as well as looking forwards to the future of global health and nutrition and considering how innovative digital technologies could be harnessed to progress this field.

This Handbook takes the reader through the entire field of pediatric thrombosis and hemostasis and has been updated since the 2nd edition with considerable new information and elements missing in previous editions. The Handbook begins with an overview of the history of pediatric thrombosis and hemostasis, followed by a concise explanation of the complex pathophysiology of thrombosis and hemostasis. It follows with chapters focused on disorders of hemostasis in children from neonates to adolescents. Subsequent chapters are focused on thrombotic complications in children together with workup and management of thrombophilias in children. New chapters on bleeding in the adolescent girl and on management of children on mechanical circulatory support (ECMO/VAD) have been added. There is also a new chapter focused on hemostatic and thrombotic challenges in children with vascular anomalies, as pediatric hemostasis and thrombosis clinicians are increasingly being asked to manage children with these conditions. This updated Handbook is intended for health care professionals involved in the assessment and care of children with inherited and acquired bleeding and thrombotic disorders to inform and facilitate diagnostic/treatment decisions. This includes general and specialist pediatricians, in particular intensivists, neonatologists, cardiologists/cardiac surgeons, rheumatologists, nephrologists, and hematologists/oncologists, as well as medical trainees, residents, fellows, nurses, nurse practitioners, physician assistants, and pharmacists.

This dermatology book is different, it brings to the fore the number of variables in morphology in skin of color, resulting in a long shopping list of differential diagnoses, which will serve as a ready reckoner for students, registrars, postgraduates, nurses, and general practitioners who are likely to encounter patients of color. Drawing on the latest scientific research and clinical expertise, the authors shed light on the incidence, presentation, and treatment of dermatoses in skin of color, for a patient population who have historically been underserved by the medical community.

Urogenital atrophy is caused by low levels of oestrogen and is mostly associated with the menopause. Symptoms can include a dry vagina and thinner vulval skin which leads to painful sex and bladder problems. The condition is very common although many women mistakenly believe the symptoms are an inevitable part of ageing and do not seek treatment. A range of treatments are available that can alleviate many of the symptoms. This booklet aims to help you understand your options, so that you can talk to your doctors, nurses and medical team about your symptoms and possible treatment.

'Fast Facts: The Gut Microbiome', though pithy and concise, is amazingly comprehensive and takes the reader through all major aspects of the human gut microbiome and microbiome science. The depth of Professor Shanahan’s knowledge of the science of the microbiome is evident throughout but what transforms this volume from a mere recitation of what we know to a truly critical and accessible exposition on what matters is the critical eye of the clinician who must make decisions that will affect a patient's health.

Marginal zone lymphoma (MZL) is a rare, slow-growing cancer of the lymphatic system that develops from a type of blood cell called a B lymphocyte. There are three distinct types of MZL - mucosa-associated lymphoid tissue (MALT) lymphoma, nodal MZL, and splenic MZL. Although MZL cannot be cured, there are effective treatments available and some people can live with MZL for many years.

The primary purpose of this Telehealth Guideline is to provide the physicians who will be managing patients virtually, with a summary of the best available evidence for the virtual management of very common conditions among adults. These guidelines are presented in a format that comprises clinical history/symptoms, differential diagnosis, investigations and management. Identification of ‘red flags’ or serious conditions associated with the condition is an essential part of these guidelines as it helps the physician to manage patients safely and appropriately by referrals, if indicated during the virtual telehealth assessment, to ER, family physicians, or specialists for face-to-face assessment.

The International System for Human Cytogenomic Nomenclature (ISCN) provides a standard approach to describe any genomic rearrangement identified by techniques ranging from karyotyping to FISH, microarray, genomic mapping, various region-specific assays, and DNA sequencing. ISCN 2024 is an indispensable reference volume for human cytogeneticists, molecular geneticists, clinical geneticists, technicians, and students for the interpretation and communication of human cytogenomic nomenclature.

This groundbreaking book encapsulates fresh insights from the 99th Nestlé Nutrition Institute Workshop in Riyadh, Saudi Arabia, in February 2023, where experts discussed the changes in the nutrition landscape brought about by the challenging times of the pandemia and globalization, including the future trajectories of child nutrition. This book delves into the profound impact of early nutrition on lifelong health and explores the intricate mechanisms of nutrition programming and the important role of human milk. It addresses the critical interplay between nutrition and epigenetic modifications, how this shapes gene expression and long-term health outcomes and emphasizes the importance of the microbiome and its modulators such as HMOs and how they support the development of the immune system in early life. Amidst the still unfolding longer-term impacts of the COVID-19 pandemic, the authors examine the bidirectional relationship between the virus and nutrition, highlighting strategies to mitigate disease severity through optimal nutrition interventions. Additionally, the book tackles the rising prevalence of food allergies, and discusses how the shift in guidelines on food allergy prevention supports the early introduction of allergens rather than avoidance as well as dietary patterns and current diets’ roles in reducing the risk of certain non-communicable diseases. The book heralds a new era in pediatric nutrition – one that embraces personalized nutrition interventions, the transformative potential of digital health, and the principles of sustainable nutrition to ensure health-promoting dietary practices. It also explores the burgeoning role of artificial intelligence in identifying new biomarkers and developing predictive models for pediatric health.

What are the mechanisms by which nutrition affects child growth and development? This is the question that this book tries to answer by presenting a comprehensive overview of the latest research on the topic.This publication covers various clinical conditions and diagnoses that involve nutrition and growth in children, based on selected peer-reviewed manuscripts that were published between July 1, 2022, and June 30, 2023. Each manuscript is briefly summarized and accompanied by editorial comments from experts in the field.The book aims to help healthcare professionals who care for growing children to better understand the complex relationship between nutrition and growth, and to apply the findings to their practice. The book also encourages readers to further explore the literature and to keep up to date on the advances in this fascinating area.

Als Mutter eines Kindes mit Diabetes Typ 1 berichtet Maren Sturny in diesem Buch über die Herausforderungen der Grundschulzeit und den Übergang auf eine weiterführende Schule. Sie teilt viele Fallbeispiele und praktische Tipps aus dem Alltag mit ihrer Tochter Nonie, die 2019 mit sechs Jahren die Diagnose Diabetes Typ 1 erhielt.Die Autorin beschreibt unterschiedliche Persönlichkeitstypen und geht ausführlich auf das allgemein wachsende Bedürfnis nach Eigenständigkeit von Grundschulkindern ein. Dieses Verständnis hilft dabei, die zunehmend wichtiger werdende Eigenständigkeit auch im Bereich des Diabetesmanagements in einen sinnvollen Kontext zu setzen und die eigenen Schützlinge leichter loszulassen. Außerdem geht die Autorin auf elterliche Sorgen, Ängste, Verantwortung und Vorbildfunktion, Teamwork, Achtsamkeit und Resilienz ein. Der für Diabeteskinder so wichtige Punkt „Kohlenhydrate schätzen“ wird in einem eigenen Kapitel aufgegriffen. Und immer steht der Gedanke im Vordergrund, dass der Alltag mit Diabetes Typ 1 am besten im Team zu meistern ist.Maren Sturny schreibt in leichter Sprache, authentisch, direkt und erfrischend, sie macht Mut, berührt, bewegt und setzt, wie bereits in ihrem ersten Buch, wertvolle Impulse. Auf Instagram und TikTok tritt sie mit ihrer Tochter Nonie im Zweiergespann als @diabetesbluemchen in Erscheinung. Außerdem engagiert sie sich, auch international, als „Patient Advocate“ mit Fokus auf Typ-1-Familien und steckt mit weiteren Initiatoren hinter der Social-Media- Kampagne www.chilldeinevorurteile.com.

This book is aimed at adult and pediatric endocrinologists, general practitioners and pediatricians, trainees in adult and pediatric endocrinology who are faced daily with the clinical challenges presented by children and adolescents with endocrine disorders. The objective is to provide rational, updated and evidence-based algorithms to guide the physician through the differential diagnoses in pediatric endocrinology. The pillars of the medical approach such as history, physical examination, laboratory and radiological investigations are included synthetically in each algorithm with a focus on the indispensable steps to achieve the correct diagnosis and start the appropriate therapy. The introduction of next-generation sequencing (NGS) has revolutionized the diagnostic approach to the child with endocrine diseases, and an appropriate focus on genetics has been included in this edition. This 4th fully rewritten edition of Practical Algorithms in Pediatric Endocrinology contains flow charts tackling the diagnostic workup of the most frequent pediatric endocrine disorders. Each step of the algorithms has a reference number quoted in the paired page with insights into the evidence and rationale supporting thestatements. Finally, an essential bibliography is included in each chapter.

The field of hemodialysis is subject to constant transformations due to continuous advances in techniques, biomaterials and devices. Based on international surveys, objective evaluations of experts and recent clinical trials, the publication at hand pays special attention to the physiological aspects of treatments as well as practical questions in the dialysis unit. Taking into account recent developments, an international group of contributors addresses issues related to vascular access, epidemiology, inflammation, fluid management, uremic toxicity, treatment efficacy, advanced techniques, calcium/phosphate homeostasis, and correction of anemia. Focusing on basic and clinical aspects of innovative technology as well as on new therapeutic options, this publication is a most helpful tool for the clinician to keep abreast of developments in the field of hemodialysis.

This book extensively reviews Polypropylene (PP), the second most widely produced thermoplastic material, having been produced for over 60 years. Its synthesis, processing and application are still accompanied by vigorous R&D developments because the properties of PP are at the borderline between those of commodity and engineering thermoplastics. Readers are introduced to various tacticities and polymorphs of PP, and their effects on structural properties. Further, the book addresses the control of optical properties using nucleants, provides strategies for overcoming the limited cold/impact resistance of PP, examines in detail the effects of recycling, and presents guidelines for the property modification of PPs through foaming, filling and reinforcing with respect to target applications. Special attention is paid to descriptions and models of properties as a function of morphological variables. Last but not least, the book suggests potential practical applications of PP-based systems, especially in the packaging, appliances, building/construction, textile and automotive sectors. Each chapter, written by internationally respected scientists, reflects the current state-of-art in the respective field and offers a vital source of information for students, researchers and engineers interested in the morphology, properties, testing and modeling of PP and PP-based systems. The content is indispensable to the appropriate application of PPs and related composites.