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The pathways and networks underlying biological functionNow in its second edition, Biochemical Pathways continues to garner praise from students, instructors, and researchers for its clear, full-color illustrations of the pathways and networks that determine biological function.Biochemical Pathways examines the biochemistry of bacteria, plants, and animals. It offers a quick overview of the metabolic sequences in biochemical pathways, the chemistry and enzymology of conversions, the regulation of turnover, the expression of genes, the immunological interactions, and the metabolic background of health disorders. A standard set of conventions is used in all illustrations, enabling readers to easily gather information and compare the key elements of different biochemical pathways. For both quick and in-depth understanding, the book uses a combination of: Illustrations integrating many different features of the reactions and their interrelationshipsTables listing the important system components and their functionText supplementing and expanding on the illustrated factsIn the second edition, the volume has been expanded by 50 percent. Text and figures have undergone a thorough revision and update, reflecting the tremendous progress in biochemical knowledge in recent years. A guide to the relevant biochemical databases facilitates access to the extensive documentation of scientific knowledge.Biochemical Pathways, Second Edition is recommended for all students and researchers in such fields as biochemistry, molecular biology, medicine, organic chemistry, and pharmacology. The book's illustrated pathways aids the reader in understanding the complex set of biochemical reactions that occur in biological systems. From the reviews: “… highly recommended for every scientist and student working in biochemistry.” –Umwelt & Gesundheit 4/2012 (review in German language)

Presenting the grand sweep of Indian history from antiquity to the present, A History of India is a detailed and authoritative account of the major political, economic, social and cultural forces that have shaped the history of the Indian subcontinent. Hermann Kulke and Dietmar Rothermund provide a comprehensive overview of the structural pattern of Indian history, covering each historical period in equal depth. Fully revised throughout, the sixth edition of this highly accessible book has been brought up to date with analysis of recent events such as the 2014 election and its consequences, and includes more discussion of subjects such as caste and gender, Islam, foreign relations, partition, and the press and television.This new edition contains an updated chronology of key events and a useful glossary of Indian terms, and is highly illustrated with maps and photographs. Supplemented by a companion website (www.routledge.com/cw/kulke), it is a valuable resource for students of Indian history.

This reference/text addresses concepts and synthetic techniques for the preparation of polymers for state-of-the-art use in biomedicine, synthetic biology, and bionanotechnology.

Victor R. Basili, Dieter Rombach, and Kurt Schneider Introduction In 1992, a Dagstuhl seminar was held on “Experimental Software Engineering Issues” (seminar no. 9238). Its goal was to discuss the state of the art of empirical software engineering (ESE) by assessing past accomplishments, raising open questions, and proposing a future research agenda. Since 1992, the topic of ESE has been adopted more widely by academia as an interesting and promising research topic, and in industrial practice as a necessary infrastructure technology for goal-oriented, sustained process improvement. At the same time, the spectrum of methods applied in ESE has broadened. For example, in 1992, the empirical methods applied in software engineering were basically restricted to quantitative studies (mostly controlled experiments), whereas since then, a range of qualitative methods have been introduced, from observational to ethnographical studies. Thus, the field can be said to have moved from experimental to empirical software engineering. We believe that it is now time to again bring together practitioners and researchers to identify both the progress made since 1992 and the most important challenges for the next five to ten years.

Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications.Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough.

This book describes computational finance tools. It covers fundamental numerical analysis and computational techniques, such as option pricing, and gives special attention to simulation and optimization. Many chapters are organized as case studies around portfolio insurance and risk estimation problems. In particular, several chapters explain optimization heuristics and how to use them for portfolio selection and in calibration of estimation and option pricing models. Such practical examples allow readers to learn the steps for solving specific problems and apply these steps to others. At the same time, the applications are relevant enough to make the book a useful reference. Matlab and R sample code is provided in the text and can be downloaded from the book's website.

Shows ways to build and implement tools that help test ideas Focuses on the application of heuristics; standard methods receive limited attention Presents as separate chapters problems from portfolio optimization, estimation of econometric models, and calibration of option pricing models

Crystalline Bacterial Cell Surface Proteins assembles information on the understanding of the occurrence, structure, chemistry, genetics, assembly, function, and application potential of S-layers. The chapters are designed to stand independent of each other and provide a complete survey of the different topics in S-layer research. This book is intended to stimulate further development in basic and applied S-layer research. Assembles present-day understanding of S-layers Provides a detailed survey of the entire field of basic and applied S-layer research Potential for broad application in biotechnology, vaccine development, diagnostics, molecular nanotechnology, and biomimetics

Computationally-intensive tools play an increasingly important role in financial decisions. Many financial problems-ranging from asset allocation to risk management and from option pricing to model calibration-can be efficiently handled using modern computational techniques. Numerical Methods and Optimization in Finance presents such computational techniques, with an emphasis on simulation and optimization, particularly so-called heuristics. This book treats quantitative analysis as an essentially computational discipline in which applications are put into software form and tested empirically.

This revised edition includes two new chapters, a self-contained tutorial on implementing and using heuristics, and an explanation of software used for testing portfolio-selection models. Postgraduate students, researchers in programs on quantitative and computational finance, and practitioners in banks and other financial companies can benefit from this second edition of Numerical Methods and Optimization in Finance.

Introduces numerical methods to readers with economics backgrounds Emphasizes core simulation and optimization problems Includes MATLAB and R code for all applications, with sample code in the text and freely available for download

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS).

This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.

Describes the spectrum of analytical tests and characterization methods necessary for developing and releasing mAb batches Details antibody heterogeneity in terms of size, charge, and carbohydrate content Gives special focus to the structural analysis of mAbs, including mass spectrometry analysis Presents the basic structure of mAbs with clarity and rigor Addresses regulatory guidelines - including ICH Q6B - in relation to quality attributes Lays out characterization and development case studies including biosimilars and new antibody formats

The book is written for students of mathematics and physics who have a basic knowledge of analysis and linear algebra. It can be used as a textbook for courses and/or seminars in functional analysis. Starting from metric spaces it proceeds quickly to the central results of the field, including the theorem of HahnBanach. The spaces (p Lp (X,(), C(X)' and Sobolov spaces are introduced. A chapter on spectral theory contains the Riesz theory of compact operators, basic facts on Banach and C*-algebras and the spectral representation for bounded normal and unbounded self-adjoint operators in Hilbert spaces. An introduction to locally convex spaces and their duality theory provides the basis for a comprehensive treatment of Fréchet spaces and their duals. In particular recent results on sequences spaces, linear topological invariants and short exact sequences of Fréchet spaces and the splitting of such sequences are presented. These results are not contained in any other book in this field.

Over the last number of years powerful new methods in analysis and topology have led to the development of the modern global theory of symplectic topology, including several striking and important results. The first edition of Introduction to Symplectic Topology was published in 1995. The book was the first comprehensive introduction to the subject and became a key text in the area. A significantly revised second edition was published in 1998 introducing new sections and updates on the fast-developing area. This new third edition includes updates and new material to bring the book right up-to-date.

Over the last number of years powerful new methods in analysis and topology have led to the development of the modern global theory of symplectic topology, including several striking and important results. The first edition of Introduction to Symplectic Topology was published in 1995. The book was the first comprehensive introduction to the subject and became a key text in the area. A significantly revised second edition was published in 1998 introducing new sections and updates on the fast-developing area. This new third edition includes updates and new material to bring the book right up-to-date.

Aquaculture exemplifies the ongoing global struggle to strike a sustainable balance between the conflicting needs of a rapidly increasing world population, human health, ecosystem health, the welfare of wild and domesticated animals, and the economic principles of globalized economies. On the one hand, aquaculture has great potential for providing us with a healthy and nutritious food supply whilst alleviating pressure on captive fisheries and reducing fisheries-induced habitat destruction, overfishing, genetic modification of wild populations, and wholesale waste of bycatch. On the other hand, aquaculture relies heavily on clean water, an increasingly precious (and dwindling) resource that is subject to intense pressure of being used for many competing objectives. This concise primer introduces students to the basic concepts, opportunities, and challenges of aquaculture with an emphasis on ecological considerations. It provides a critical assessment of current aquaculture practices from a broad, interdisciplinary perspective and from the standpoint of how best to align the two major (and often conflicting) goals of future aquaculture development: minimizing reliance on ecosystem services whilst maximizing productivity. A Primer of Ecological Aquaculture provides an accessible and authoritative overview for a wide range of undergraduate majors ranging from biology, engineering, and environmental policy to business and management. It will also appeal to a more general academic audience who wish to gain a current overview of the field.

Aquaculture exemplifies the ongoing global struggle to strike a sustainable balance between the conflicting needs of a rapidly increasing world population, human health, ecosystem health, the welfare of wild and domesticated animals, and the economic principles of globalized economies. On the one hand, aquaculture has great potential for providing us with a healthy and nutritious food supply whilst alleviating pressure on captive fisheries and reducing fisheries-induced habitat destruction, overfishing, genetic modification of wild populations, and wholesale waste of bycatch. On the other hand, aquaculture relies heavily on clean water, an increasingly precious (and dwindling) resource that is subject to intense pressure of being used for many competing objectives. This concise primer introduces students to the basic concepts, opportunities, and challenges of aquaculture with an emphasis on ecological considerations. It provides a critical assessment of current aquaculture practices from a broad, interdisciplinary perspective and from the standpoint of how best to align the two major (and often conflicting) goals of future aquaculture development: minimizing reliance on ecosystem services whilst maximizing productivity. A Primer of Ecological Aquaculture provides an accessible and authoritative overview for a wide range of undergraduate majors ranging from biology, engineering, and environmental policy to business and management. It will also appeal to a more general academic audience who wish to gain a current overview of the field.

The German 'Blitz' that followed the Battle of Britain killed tens of thousands and laid waste to large areas of many British cities. And although the destruction of 1940-1 was never repeated on the same scale, fears that Hitler possessed a secret weapon of mass destruction never entirely died, and were partially realized in the VI and V2 raids of 1944-5. The British and American response to the 'Blitz', especially from 1943 onwards, was massive and incomparably more devastating - with apocalyptic consequences for German cities such as Hamburg, Dresden, and Berlin, to name but the most prominent. In this ground-breaking new book, German historian Dietmar Süss investigates the effects of the bombing on both Britain and Nazi Germany, showing how these two very different societies sought to withstand the onslaught and keep up morale amidst the material devastation and psychological trauma that was visited upon them. And, as he reflects in the conclusion, this is not a story that is safely confined to the past: the debate over the rights and the wrongs of the mass bombing of British and German cities during World War II remains a highly emotional subject even today.

Gerhard Richter is one of the most important and popular artists of the postwar era. For decades he has sought innovative ways to make painting more relevant, often through a multifaceted dialogue with photography. Today Richter is most widely recognized for the photo-paintings he made during the 1960s that rely on images culled from mass media and pop culture. Always fascinated with the limits and uncertainties of representation, he has since then produced landscapes, abstractions, glass and mirror constructions, prints, sculptures, and installations. Though Richter has been known in the United States for quite some time, the highly successful retrospective of his work at the MOMA in 2002 catapulted him to unprecedented fame. Enter noted curator Dietmar Elger, who here presents the first biography of this contemporary artist. Written with full access to Richter and his archives, this fascinating book offers unprecedented insight into his life and work.Elger explores Richter's childhood in Nazi Germany; his years as a student and mural painter in communist East Germany; his time in the West during the turbulent 1960s and '70s, when student protests, political strife, and violence tore the Federal Republic of Germany apart; and, his rise to international acclaim during the 1980s and beyond. Richter has always been a difficult personality to parse, and the seemingly contradictory strands of his artistic practice have frustrated and sometimes confounded critics. But the extensive interviews on which this book is based disclose a Richter who is far more candid and vivid than ever before. The result is a book that will be the foundational portrait of this artist and his profoundly influential oeuvre.

An authoritative analysis of the political, economic, and social developments behind India’s dramatic rise in global statureWith growing economic might, new political influence, and changing social dynamics, India has emerged as a major world power in the twenty-first century. This book charts the important features of India’s development since its independence in 1947, assessing those forces that have contributed to the nation’s growth as well as those that have impeded it. Through the lens of India’s past, Dietmar Rothermund offers a new perspective on India today and a fascinating look into the nation’s future.The author explores the diverse roots of India’s economic robustness, from agriculture to the export boom. He looks closely at the country’s democratic system, nuclear decisions, and alliance with the U.S. against terror. In his review of social changes, Rothermund discusses the institution of caste, the rise of a new middle class, the persistence of poverty, the media and Bollywood, and the significance of the global diaspora of twenty million Indians. In sum, he offers an impressive profile of India, an Asian giant whose role in the world’s future will surely be unique and important.

The intersection of informetrics and information retrieval (IR) research provides valuable insights for IR system modeling, design, and evaluation. This work introduces readers to informetric aspects of IR system contents and their use, and how knowledge of these patterns may be applied to better understandIR processes and their users.The recent wider availability of information retrieval technologies, due in large part to the growth of the Internet, has prompted an increase in research interest into the effective design and use of IR (information retrieval) systems. This work introduces readers to concepts of informetrics as they relate to IR, and how the intersection of these two subject areas can provide valuable insights for IR research.Informetrics, briefly summarized as the quantitative study of recorded discourse, can provide perspectives on patterns of information production and use. It also offers methodologies that may be applied in IR research that are often overlooked. Informetric analysis of IR systems can shed light on underlying patterns of IR system contents and how users interact with these systems. Applications of informetrics for IR research include the modeling and simulation of IR systems, file design and space planning, system design and implementation, system evaluation, and the targeting of services to users. Readers will learn about the scope of informetrics, informetric modeling techniques, informetric characteristics of IR systems and how they are used, and how knowledge of these characteristics may be applied in IR research.

The objective of this present volume is to analyse the response to the developments and the consequences for the conduct of monetary policy in five industrial countries. Also considered is the stability of hitherto established relationships between economic variables on which the reliability of monetary policy measures depends. The volume further covers some of the international aspects involved and the important implications of the emerging dominant and persistent flows of long-term capital across the exchanges.

Concilium has long been a household-name for cutting-edge critical and constructive theological thinking. Past contributors include leading Catholic scholars such as Hans Küng, Gregory Baum and Edward Schillebeeckx, and the editors of the review belong to the international "who's who" in the world of contemporary theology.