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Selected as a Doody’s Essential Title for 2025!For 40 years, Fischer’s Mastery of Surgery has provided expert, highly illustrated coverage of the procedures that general surgeons and trainees need to know. The fully revised eighth edition, under the editorial leadership of Drs. E. Christopher Ellison, Gilbert R. Upchurch Jr., Philip A. Efron, Steven D. Wexner, Nancy D. Perrier, V. Suzanne Klimberg, John H. Stewart IV, Valerie W. Rusch, Jon C. Gould, Susan Galandiuk, Timothy M. Pawlik, William C. Chapman, Benjamin K. Poulose, Peter K. Henke, Alicia M. Mohr, Saleem Islam, Anne M.R. Agur, Carol Scott-Conner, and David Renton continues the tradition of excellence with two full-color volumes that include the essentials of diagnosis, anatomy, and pre-operative planning while maintaining a focus on clear, step-by-step depictions and descriptions of procedures.  Brings you up to date with evidence-based approaches for virtually any surgery you’ll be called upon to perform  Provides extensive coverage (including select procedural videos) of common thoracic, breast, esophageal, endocrine, colorectal, gastric, pancreatic, liver, biliary, vascular, and transplantation procedures across 311 chapters  Includes new sections on perioperative care and critical care; abdominal core health; trauma, burn, and acute care surgery; and pediatric surgery as well as new Mastery Keys anatomy chapters  Walks you step by step through each procedure, with tips and cautions from leading surgeons  Concludes each chapter with expert editorial commentary that puts the chapter material in a broad context and provides helpful critiques of the most recent literature  Features more than 2,600 illustrations and photographs that offer a surgeon’s-eye-view of the most advanced approaches  The VST Ebook includes 85 videos of procedures presented in the book!   Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone.  Easily convert to audiobook, powering your content with natural language text-to-speech.

Thus instead of being synonymous with specific procedures per- formed at the level of the basal ganglia, stereotaxis is in fact a general diagnostic and therapeutic concept, which has as its aim the precise three-dimensional representation of the patient's brain in its entirety. This three-dimensional representation is based on anatomical, neuro- radiological and other localizing information, the spatial integration Prof. Jean Talairach with friends and coworkers at the congress dinner in the Royaumont Abbey near Paris. (From left to right: Drs. ]. Bancaud, N. T. Zervas, B. Nashold, ]. Talairach, G. Szikla, F. Mundinger, P. Tournoux, ]. Peeker) of which allows a more precise "anatomical" approach to the human brain and to the surgical management of localized pathologic proces- ses. Literally, stereotaxis means "orientation in space". Taken in this general sense, all surgical procedures obviously should be stereo- tactic, at least in their principle!Two of the main themes of our meeting, namely the topic of the first day, "Surgery of Epilepsy" and that of the second "Stereotactic Cerebral Irradiation" of small brain tumours correspond to this evolution toward a global "whole brain" concept of stereotaxis. The same philosophy inspired the scientific efforts of the stereotactic group Introduction 3 of the Sainte Anne Hospital, under the leadership of its promoter, Professor Jean Talairach. This is the reason why the present Meeting is dedicated in honor of his scientific work.

This book is Volume 2 of the EUROCK 2018 proceedings. Geomechanics and Geodynamics of Rock Masses contains contributions presented at EUROCK 2018, the 2018 International Symposium of the International Society for Rock Mechanics (ISRM 2018, Saint Petersburg, Russia, 22-26 May 2018). Dedicated to recent advances and achievements in the fields of geomechanics and geotechnology, the main topics of the book include:- Physical and mechanical properties of fractured rock (laboratory testing and rock properties, field measurements and site investigations)- Geophysics in rock mechanics- Rock mass strength and failure- Nonlinear problems in rock mechanics- Effect of joint water on the behavior of rock foundation- Numerical modeling and back analysis- Mineral resources development: methods and rock mechanics problems- Rock mechanics and underground construction in mining, hydropower industry and civil engineering- Rock mechanics in petroleum engineering- Geodynamics and monitoring of rock mass behavior- Risks and hazards- Geomechanics of technogenic depositsGeomechanics and Geodynamics of Rock Masses will be of interest to researchers and professionals involved in the various branches of rock mechanics and rock engineering. EUROCK 2018, organized by the Saint Petersburg Mining University, is a continuation of the successful series of ISRM symposia in Europe, which began in 1992 in Chester, UK.

The International Committee on Large Dams (ICOLD) held its 26th International Congress in Vienna, Austria (1-7 July 2018). The proceedings of the congress focus on four main questions: 1. Reservoir sedimentation and sustainable development; 2. Safety and risk analysis; 3. Geology and dams, and 4. Small dams and levees. The book thoroughly discusses these questions and is indispensable for academics, engineers and professionals involved or interested in engineering, hydraulic engineering and related disciplines.

Materials for Ultra-Supercritical and Advanced Ultra-Supercritical Power Plants provides researchers in academia and industry with an essential overview of the stronger high-temperature materials required for key process components, such as membrane wall tubes, high-pressure steam piping and headers, superheater tubes, forged rotors, cast components, and bolting and blading for steam turbines in USC power plants. Advanced materials for future advanced ultra-supercritical power plants, such as superalloys, new martensitic and austenitic steels, are also addressed. Chapters on international research directions complete the volume.

The transition from conventional subcritical to supercritical thermal power plants greatly increased power generation efficiency. Now the introductions of the ultra-supercritical (USC) and, in the near future, advanced ultra-supercritical (A-USC) designs are further efforts to reduce fossil fuel consumption in power plants and the associated carbon dioxide emissions. The higher operating temperatures and pressures found in these new plant types, however, necessitate the use of advanced materials.

Provides researchers in academia and industry with an authoritative and systematic overview of the stronger high-temperature materials required for both ultra-supercritical and advanced ultra-supercritical power plants Covers materials for critical components in ultra-supercritical power plants, such as boilers, rotors, and turbine blades Addresses advanced materials for future advanced ultra-supercritical power plants, such as superalloys, new martensitic and austenitic steels Includes chapters on technologies for welding technologies

Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention In-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors; tyrosine protein kinases and adaptive immunity; and intracellular calcium Extensive conceptual color artwork to assist with comprehension of key topics Instrumental margin notes highlight milestones in signaling mechanisms

This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases.

This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.

For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

The record of man's early evolution, though still fragmentary, is more complete on the African continent than anywhere else in the world. The ecological context of this evolution, however, has been studied intensively only in recent years. This pioneering volume draws together eminent specialists from many fields--physical anthropologists, zoologists, geologists, paleontologists, and prehistorians--who summarize here the results of their diverse research on Pleistocene environments and the cultural and biological evolution of man in Africa.This volume was sponsored by the Wenner-Gren Foundation for Anthropological Research Inc., which met at Burg Wartenstein, Austria. The editors have field experience in Africa, especially eastern and equatorial Africa. This experience is coupled with their awareness of the need to integrate results of numerous field studies bearing on the biological-behavioral evolution of higher primates with other field studies on the paleoecology and the mammalian ecology of sub-Saharan Africa.The book includes contributions on Pleistocene stratigraphy and climatic changes throughout the African continent; on the origin and evolution of the earliest man-like creatures in Africa; on the dating, distribution, and adaptation of Pleistocene hunter-gatherer peoples; and on the ecology, biology, and social behavior of African primate and human populations. The chapters reflect vividly the state of current knowledge at the time and indicate paths for future research. Over 100 maps and figures, detailed bibliographies, and a comprehensive index contribute to the importance of the volume for basic reference use.

**Selected for 2026 Doody's Core Titles in Molecular Biology**Diagnostic Molecular Biology, Second Edition provides an up-to-date comprehensive overview of the latest advances in molecular diagnostics and the fundamental molecular aspects in this area. The book delves into the essential principles behind the transmission and expression of genetic information, including nucleic acids, proteins, and chromosomes, specifically their genome structure, life cycle, and evolution. The latest methods and instrumentation in the field are examined with detailed procedures and explanations provided for each technique. A range of techniques are also investigated, such as those used in sequencing analysis, genome and transcriptome analysis, and nucleic acid amplitification techniques. This book covers the collection, isolation, and purification of DNA, RNA, and protein from different sources. Additionally, discussion on the applications of next-generation sequencing (NGS) and the role of NGS in the future of precision medicine is included. The book also examines the use of molecular diagnostics for chromosomal disorders, inherited diseases, and infectious diseases. Moreover, this new edition features recent advances in the detection of respiratory virus infections in humans, including that of SARS-CoV2. Diagnostic Molecular Biology, Second Edition, is an ideal reference for researchers, lab technicians, and students in medical laboratory science, molecular biology, microbiology, virology, and related fields.

Provides explanations on how techniques are used to diagnosis at the molecular level Explains how to use information technology to communicate and assess results in the lab Enhances our understanding of fundamental molecular biology and places techniques in context Places protocols into context with practical applications Includes extra chapters on respiratory viruses (Corona)

Inherited White Matter Disorders and Their Mimics, Volume 204 discusses where imaging abnormalities and pathology lie predominantly in the CNS white matter. Many acquired causes, such as multiple sclerosis, are readily diagnosed and familiar to the majority of neurologists. However, less common acquired causes and genetic disorders (the leukodystrophies and genetic leukoencephalopathies) often present a diagnostic challenge. The evaluation of patients with White matter disorders (WMDs) has evolved enormously in recent decades, due to advances in genetics, radiology, and the development of treatments for specific disorders. This book brings together WMD research, spanning basic science, molecular genetics, and clinical and radiological phenotyping.This volume presents both common WMDs and rare disorders according to their presentations or pathophysiology. Chapters lay out the clinical and radiological presentation of the disorder, followed by genetics and diagnostics, and finally discussion of pathophysiology and treatment. Chapter contain imaging, clinical pearls to diagnosis, and reference tables for genotype-phenotype correlation. For diagnostic work-up, easy to read algorithms are presented as well as clear guidance on indications for treatment, where applicable.

Includes common and rare white matter disorders (WMDs)Summarizes advances in genetics, radiology, and treatments for WMDsProvides clinical and radiological phenotypingContains imaging, diagnostic algorithms, and guidance on treatment

First published in 1987.Often the best known and most memorable passages in Shakespeare's plays, the soliloquies, also tend to be the focal points in the drama. Twenty-seven soliloquies are examined in this work, illustrating how the spectator or reader is led to the soliloquy and how the drama is continued afterwards. The detailed structure of each soliloquy is discussed, as well as examining them within the structure of the entire play - thereby extending the interpretation of the work as a whole.

First published in 1987.Often the best known and most memorable passages in Shakespeare's plays, the soliloquies, also tend to be the focal points in the drama. Twenty-seven soliloquies are examined in this work, illustrating how the spectator or reader is led to the soliloquy and how the drama is continued afterwards. The detailed structure of each soliloquy is discussed, as well as examining them within the structure of the entire play - thereby extending the interpretation of the work as a whole.

Excavation, Support and Monitoring is the fourth volume of the five-volume set Rock Mechanics and Engineering and contains twenty-three chapters from key experts in the following fields- Excavation Methods;- Support Technology;- Monitoring Technology;- Integrated Engineering Monitoring and Analysis.The five-volume set “Comprehensive Rock Engineering”, which was published in 1993, has had an important influence on the development of rock mechanics and rock engineering. Significant and extensive advances and achievements in these fields over the last 20 years now justify the publishing of a comparable, new compilation. Rock Mechanics and Engineering represents a highly prestigious, multi-volume work edited by Professor Xia-Ting Feng, with the editorial advice of Professor John A. Hudson. This new compilation offers an extremely wide-ranging and comprehensive overview of the state-of-the-art in rock mechanics and rock engineering and is composed of peer-reviewed, dedicated contributions by all the key experts worldwide.Key features of this set are that it provides a systematic, global summary of new developments in rock mechanics and rock engineering practices as well as looking ahead to future developments in the fields. Contributors are world-renowned experts in the fields of rock mechanics and rock engineering, though younger, talented researchers have also been included. The individual volumes cover an extremely wide array of topics grouped under five overarching themes: Principles (Vol. 1), Laboratory and Field Testing (Vol. 2), Analysis, Modelling and Design (Vol. 3), Excavation, Support and Monitoring (Vol. 4) and Surface and Underground Projects (Vol. 5). This multi-volume work sets a new standard for rock mechanics and engineering compendia and will be the go-to resource for all engineering professionals and academics involved in rock mechanics and engineering for years to come.

Nanoelectronic Device Applications Handbook gives a comprehensive snapshot of the state of the art in nanodevices for nanoelectronics applications. Combining breadth and depth, the book includes 68 chapters on topics that range from nano-scaled complementary metal–oxide–semiconductor (CMOS) devices through recent developments in nano capacitors and AlGaAs/GaAs devices. The contributors are world-renowned experts from academia and industry from around the globe.The handbook explores current research into potentially disruptive technologies for a post-CMOS world. These include:Nanoscale advances in current MOSFET/CMOS technologyNano capacitors for applications such as electronics packaging and humidity sensorsSingle electron transistors and other electron tunneling devicesQuantum cellular automata and nanomagnetic logicMemristors as switching devices and for memoryGraphene preparation, properties, and devicesCarbon nanotubes (CNTs), both single CNT and random networkOther CNT applications such as terahertz, sensors, interconnects, and capacitorsNano system architectures for reliabilityNanowire device fabrication and applicationsNanowire transistorsNanodevices for spintronicsThe book closes with a call for a new generation of simulation tools to handle nanoscale mechanisms in realistic nanodevice geometries. This timely handbook offers a wealth of insights into the application of nanoelectronics. It is an invaluable reference and source of ideas for anyone working in the rapidly expanding field of nanoelectronics.

The Handbook of Software for Engineers and Scientists is a single-volume, ready reference for the practicing engineer and scientist in industry, government, and academia as well as the novice computer user. It provides the most up-to-date information in a variety of areas such as common platforms and operating systems, applications programs, networking, and many other problem-solving tools necessary to effectively use computers on a daily basis.Specific platforms and environments thoroughly discussed include MS-DOS®, Microsoft® Windows™, the Macintosh® and its various systems, UNIX™, DEC VAX™, IBM® mainframes, OS/2®, Windows™ NT, and NeXTSTEP™. Word processing, desktop publishing, spreadsheets, databases, integrated packages, computer presentation systems, groupware, and a number of useful utilities are also covered. Several extensive sections in the book are devoted to mathematical and statistical software. Information is provided on circuits and control simulation programs, finite element tools, and solid modeling tools. Additional coverage is included on data communications and networking.Many appendices at the end of the book provide useful supplemental information, such as ASCII codes, RS-232 parallel port and pinout information, and ANSI escape sequences.This valuable resource handbook brings together a wide variety of topics and offers a wealth of information at the reader's fingertips.

Agency theory examines the relationship between individuals or groups when one party is doing work on behalf of another. 'Agency and Identity in the Ancient Near East' offers a theoretical study of agency and identity in Near Eastern archaeology, an area which until now has been largely ignored by archaeologists. The book explores how agency theory can be employed in reconstructing the meaning of spaces and material culture, how agency and identity intersect, and how the availability of a textual corpus may impact on the agency approach. Ranging from the Neolithic to the Islamic period, 'Agency and Identity in the Ancient Near East' covers sites located in Turkey, Iraq, Syria, Jordan, Palestine, and Israel. The volume includes contributions from philology, art, history, computer simulation studies, materials science, and the archaeology of settlement and architecture.

Celebrate 50 years of speed, innovation, and precision engineering in this stunningly illustrated collector’s tribute to Audi’s high-performance icons—S and RS.From the legendary Quattro rally cars of the 1980s to the modern RS e-tron GT, Audi S and RS charts the complete evolution of Audi’s most coveted performance line. Authored by Russell Hayes, this lavish history showcases more than 200 photographs spanning concept sketches, race victories, and today’s precision-built super sedans and Avants. Discover how RennSport (“racing sport”) became synonymous with understated power and design discipline—and how Audi translated its World Rally Championship dominance into street-legal innovation.Take a visually thrilling ride through:Quattro’s Rally Heritage—The 1980 debut that changed motorsport forever, with victories by Hannu Mikkola, Walter Röhrl, Michèle Mouton, and Stig Blomqvist.The Birth of RS—The rare 1994 RS 2 Avant, co-developed with Porsche, establishing Audi’s performance DNA.S and RS Icons—From S4 and RS 6 Avant to the R8 and RS e-tron GT, every generation combining German engineering precision with daily-driver practicality.Design and Technology—Audi’s aluminum spaceframes, quattro all-wheel drive, turbocharging, and electrification—all explored through insider analysis and high-impact photography.Full Technical Specifications—complete tech specs for every generation of S and RS.Audi S and RS is the definitive visual and historical record of Audi’s pursuit of performance excellence. Whether you’re a collector, designer, or lifelong enthusiast, this beautifully produced hardcover delivers the craftsmanship, authority, and aesthetic detail that have helped define Audi for decades.