Principles of Bone Biology (inbunden)
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Inbunden (Hardback)
Antal sidor
Academic Press
P.Bilezikian, John / G.Raisz, Lawrence / Martin, T. John
Illustrations (some col.)
304 x 254 x 101 mm
5352 g
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2 Hardbacks
Principles of Bone Biology (inbunden)

Principles of Bone Biology

Inbunden Engelska, 2008-10-15
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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

  • Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one is all in one source written by the experts in the field
  • The essential resource for anyone involved in the study of bones and bone diseases
  • Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics
  • Readers can easily search and locate information quickly as it will be online with this new edition
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Praise for the previous edition:
"Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

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John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expre...


Part I Basic Principles A. Cell Biology Chapter 1: Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity Chapter 2: Biomechanics of Bone Chapter 3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation Chapter 4: Mesenchymal Stem Cells & Osteoblast Lineage Chapter 5: Transcriptional Control of Osteoblast Differentiation and Function Chapter 6: Wnt Signaling and Bone Chapter 7: Sclerostin and Bone Chapter 8: The Osteocyte Chapter 9: Cells of Bone: Osteoplast Generation Chapter 10: Osteoclast Function: Biology and Mechanisms Chapter 11: RANK Signaling Chapter12: Regulating Bone Resorption Chapter 13: Apoptosis in Bone Cells Chapter 14: Skeletal Gene Expression in Nuclear Microenvironments B. Biochemistry Chapter 15: Type I Collagen: Structure, Synthesis, and Regulation Chapter 16: Collagen Crosslinking & Metabolism Chapter 17: Bone Matrix Proteoglycans & Glycoproteins Chapter 18: Osteopontin Chapter 19: Bone Proteinases Chapter 20: Integrins and Other Cell Surface Attachment Molecules of Bone Cells Chapter 21: Intercellular Junctions and Cell-Cell Communication in the Skeletal System C. Bone Remodeling and Mineral Homeostasis Chapter 22: Histomorphometric Analysis of Bone Remodeling Chapter 23: Phosphorus Homeostasis & Related Disorders Chapter 24: Magnesium Homeostasis Chapter 25: Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Stro Chapter 26: Biology of the Extracellular Ca2+-Sensing Receptor D. The Hormones of Bone Chapter 27: Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein Chapter 28: Parathyroid Hormone - Molecular Biology Chapter 29: Parathyroid Hormone-Receptor Interactions Chapter 30: Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System Chapter 31: The Vascular and Cardiovascular Actions of PTH Chapter 32: PTH and PTHrP Actions on Kidney and Bone Chapter 33: Physiological Actions of Parathyroid Hormone and PTH-Related Protein Chapter 34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein Chapter 35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses Chapter 36: Vitamin D Gene Regulation Chapter 37: Photobiology and Non-Calcemic Actions of Vitamin D Chapter 38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects Chapter 39: Amylin and Calcitonin Gene-Related Peptide E. Other Systemic Hormones That Influence Bone Metabolism Chapter 40: Estrogens & Progestins Chapter 41: The Pharmacology of Selective Estrogen Receptor Modulators Chapter 42: Mechanisms of Estrogen Action in Bone Chapter 43: Thyroid Hormone & Bone Chapter 44: Clinical and Basic Aspects of Glucocorticoid Action in Bone Chapter 45: Effects of Diabetetes & Insulin on Bone Physiology Chapter 46: Androgens:Receptor Expression and Steroid Action in Bone Chapter 47: Kinins & Neuro-Osteogenic Factors Chapter 48: Regulation of Bone Remodeling by Central and Peripheral Nervous Signals Patricia Ducy F. Local Regulators Chapter 49: Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology Chapter 50: Platelet-Derived Growth Factor & the Skeleton Chapter 51: Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone Chapter 52: Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling Chapter 53: Transforming Growth Factor-a Chapter 54: Bone Morphogenetic Proteins and the Skeleton Chapter 55: Bone Morphogenetic Protein Receptors & Actions Chapter 56: Colony-Stimulating Factor-1 Chapter 57: Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines Chapter 58: Prostaglandins & Bone Metabolism Carol P