Osteoporosis (inbunden)
Inbunden (Hardback)
Antal sidor
Academic Press
Dempster, David W. / Cauley, Jane A. / Feldman, David
285 x 234 x 114 mm
6531 g
Antal komponenter
2 Hardbacks
Osteoporosis (inbunden)


Inbunden Engelska, 2013-08-07
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Now in its fourth edition, Osteoporosis is a classic reference on this disease, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume work is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in which direct care costs for osteoporotic fractures in the United States reach up to $18 billion each year. Worldwide, 200 million women ages 60 to 80 suffer from osteoporosis and have a lifetime risk of fracture between 30% and 40%, continuing to make osteoporosis a critical challenge in medicine.

  • Recognizes the critical importance of the Wnt signaling pathway for bone health
  • Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone
  • Examines essential updates on estrogen prevention and treatment and the recent results from the WHO
  • Discusses the controversial topics of screening and clinical trial design for drug registration
  • Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone
  • Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics
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Fler böcker av Robert Marcus

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Praise for Previous Edition:
"...Osteoporosis is quite comprehensive; indeed, topics that typically receive brief treatment elsewhere (osteoporosis in minority groups and in men) receive entire chapters here..."--THE NEW ENGLAND JOURNAL OF MEDICINE

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Övrig information

Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education, & Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus' laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck's Fracture Intervention Trial (FIT), Lilly's Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly's registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly & Company to support Lilly's program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone & Mineral Research in 2000-2001. David W. Dempster, PhD, is Professor of Clinical Pathology and Cell Biology at Columbia University in New York. He obtained his PhD from the University of Glasgow in Scotland and completed postdoctoral studies in Switzerland and France. Dr. Dempster is a Past President of the International Society of Bone Morphometry and a member of the Scientific Advisory Council of the National Osteoporosis Foundation. He is also a Fellow of the Royal Microscopical Society. Dr. Dempster's iconic micrographs of osteoporotic bone have been widely reproduced in the scientific and popular press, including being displayed at the Smithsonian Institution in Washington, DC. Dr. Dempster is an Associate Editor of Osteoporosis International, and serves on the editorial boards of the Journal of Bone and Mineral Research, Bone and the Journal of Clinical Densitometry. His research studies have been continuously supported by the National Institutes of Health for the past 25 years. Dr. Dempster has published over 200 research papers on the pathophysiology and treatment of bone disese. Dr. Cauley is Professor and Vice Chair for Research, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh (Pennsylvania). Her p...


Introduction The Bone Organ System: Form and Function The Nature of Osteoporosis The Economics of Osteoporosis Reflections on Osteoporosis Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of Osteoporosis Basic Science/Bone Biology Osteoblast Biology Osteoclast Biology Osteocytes The Regulatory Role of Matrix Proteins in Mineralization of Bone Development of the Skeleton Mouse Genetics as a Tool to Study Bone Development and Physiology Parathyroid Hormone and Parathyroid Hormone-Related Protein Vitamin D: Biology, Action, and Clinical Implications Regulation of Bone Cell Function by Estrogens Androgens and Skeletal Biology: Basic Mechanisms Phosphatonins Wnt Signaling in Bone Cytokines and Bone Remodeling Skeletal Growth Factors Intercellular Communication During Bone Remodeling Structural and Biomechanics Skeletal Development: Mechanical Consequences of Growth, Aging and Disease Inhibition of Osteoporosis by Biophysical Intervention Biomechanics of Age-Related Fractures Bone Quality Epidemiology & Risk Factors Epidemiologic Methods in Studies of Osteoporosis Race, Ethnicity and Osteoporosis The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions Bone Mineral Acquisition in Utero and During Infancy and Childhood Bone Acquisition in Adolescence Genetic Determinants of Osteoporosis Nutrition and Risk for Osteoporosis Physical Activity in Prev