Principles of Bone Biology (inbunden)
Inbunden (Hardback)
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Academic Press
P.Bilezikian, John / Martin, T. John / L.Clemens, Thomas / Rosen, Clifford
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Volume 1+2
Principles of Bone Biology (inbunden)

Principles of Bone Biology

Inbunden Engelska, 2019-08-23
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Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science. we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan

Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science.

This new edition builds on the successful formula from previous editions, taking thereader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology.

  • Provides a "one-stop" shopping paradise. Anything you want to find about bone biology is here and written by the world's experts
  • THE essential resource for anyone involved in the study of the skeleton and metabolic bone diseases
  • Covers everything from the basic scientific concepts to the underlying principles of therapeutics and management
  • Allows readers to easily search and locate information quickly in the online format
  • Volumes include: Basic Principles; Molecular Mechanisms of Metabolic Bone Disease; Pharmacological Mechanisms of Therapeutics; Methods in Bone Research
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Review of the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

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Dr. Bilezikian is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. He belongs to the American Society for Bone and Mineral Research (President 1995-1996), and the International Society of Clinical Densitometry (President, 1999-2001). He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present) and is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013).

Dr. Bilezikian is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700. Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein. Thomas Clemens works at the Johns Hopkins University in the Department of Orthopaedic Surgery, Baltimore, MD, USA Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor.

Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal...


PART I - Basic Principles A. Cell Biology 1. Endochondral and Intramembraneous Bone Development; 2. Mesenchymal Stromal Cells; 3. Hematopoietic-Bone Cell Interactions; 4. Osteoblasts; 5. Osteoclasts; 6. Osteocytes; 7. Transcriptional Control of Osteoblast Differentiation; 8. Wnt Signaling and Bone Cell Activity; 9. Vascular and Nerve Interactions; 10. Coupling of Bone Formation and Resorption; 11. Bone Remodeling; 12. Aging and Bone B. Biochemistry 13. Type I Collagen Structure, Synthesis, and Regulation; 14. Collagen Cross-Linking and Metabolism; 15. Noncollagenous Bone Matrix Proteins (including osteopontin); 16. Bone Proteinases; 17. Integrins and Other Cell Surface Attachment Molecules of Bone Cells; 18. Intercellular Junctions and Cell-Cell Communication in the Skeletal System C. Bone Remodeling and Mineral Homeostasis 19. Histomorphometric Analysis of Bone Remodeling; 20. Phosphorus Homeostasis and Related Disorders; 21. Magnesium Homeostasis; 22. Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lanthanum, Lead, Silicon, and Strontium; 23. Biology of the Extracellular Ca2+-Sensing Receptor D. Endocrine and Paracrine Regulation of Bone 24. Parathyroid Hormone: Molecular Biology; 25. Paracrine PTHrP in Bone: Physiology and Pharmacology; 26. Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System and Vascular, Cardiovascular, and Neurological Actions of Parathyroid-Related Protein; 27. PTH and PTHrP Actions on Kidney; 28. Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein; 29. 1 ,25(OH)2 Vitamin D3Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses; 30. Vitamin D Gene Regulation; 31. Noncalcemic Actions of Vitamin D; 32. Cellular Actions of Parathyroid Hormone; 33. Calcitonin peptides; 34. Regulation of Bone Remodeling by Central and Peripheral Nervous E. Other Systemic Hormones that Influence Bone Metabolism 35. Estrogens and Progestins; 36. Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein: Epidermal, Mammary, Reproductive, Pancreatic Tissues; 37. The Pharmacology of Selective Estrogen Receptor Modulators; 38. Thyroid Hormone and Bone; 39. Clinical and Basic Aspects of Glucocorticoid Action in Bone; 40. Androgens Receptor Expression and Steroid Action in Bone F. Local Regulators 41. Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology; 42. Platelet-Derived Growth Factor and the Skeleton; 43. Notch Signaling and its Ligands; 44. Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone; 45. Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling; 46. Transforming Growth Factor-ss; 47. Bone Morphogenetic Proteins and the Skeleton and Bone Morphogenetic Protein Receptors and Actions; 48. Non-Skeletal Actions of RANK Ligand; 49. Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon- , the LIF/IL-6 Family, and Additional Cytokines; 50. Prostaglandins and Bone Metabolism PART II - Molecular Mechanisms of Metabolic Bone Disease 51. Molecular Actions of PTH1R and their implications; 52. Multiple Endocrine Neoplasia Type 1; 53. Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy; 54. Localized Osteolysis; 55. Genetic Regulation of Parathyroid Gland Development; 56. Genetic Disorders Caused by PTH/PTHrP Receptor Mutations; 57. Molecular Basis of PTH Overexpression; 58. Diseases Resulting from Defects in the G Protein Gs ; 59. Renal Osteodystrophy: Pathogenic Mechanisms and Therapeutic Options; 60. Osteogenesis Imperfecta; 61. Hereditary Deficiencies in Vitamin D Action; 62. FGF 23; 63. Tumor-Induced Osteomalacia; 64. Osteopetrosis; 65. Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans; 66. Paget's Disease of Bone; 67. Genetic Determinants of Bone Mass and Osteoporotic Fracture / Genomic Approaches in Skeletal Resear