Crystals, X-rays and Proteins (häftad)
Häftad (Paperback)
Antal sidor
OUP Oxford
Cooper, Jon
250 b/w line and halftone illustrations
254 x 177 x 31 mm
1270 g
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Crystals, X-rays and Proteins (häftad)

Crystals, X-rays and Proteins

Comprehensive Protein Crystallography

Häftad Engelska, 2015-03-19
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Information derived from X-ray crystal structures of biological molecules allows us to explain their functions in living organisms in extraordinary detail, and to develop drugs to treat disease. This book describes the principles and practice of X-ray diffraction as a key technique at the forefront of new discoveries in biology and medicine.
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Recensioner i media

Joseph D. Ferrara, Ph.D, Crystallography Times The first two-thirds of this book was like a thriller to me. Even though I knew the answer, I wanted to see how the author would address the next topic and I could not put it down.

Nicholas M. Glykos, Democritus University of Thrace, Greece This is one of the best crystallography books ever written, and it is with pleasure that I wholeheartedly recommend it.

E. von Castelmur and A. Perrakis, Crystallography Reviews The authors have nicely brought the bibliography up to date and mention recent method developments, giving a good first grasp of what is involved in solving a structure. The text also makes good use of accompanying, illustrative figures, which is most essential when developing the complex concepts of diffraction, Fourier transformation and convolution.

Manfred S. Weiss, Acta Crystallographica Section D In my opinion, this book would be the perfect textbook for a theoretical course on macromolecular crystallography

Karen McLuskey, Chemistry World A welcome addition to any structural biology laboratory, [and] an invaluable reference, answering questions in an accurate and transparent manner

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Övrig information

Dennis Sherwood read Natural Sciences as a scholar at Clare College, Cambridge, and subsequently won a Mellon Fellowship to the Department of Molecular Biophysics and Biochemistry at Yale University (MPhil), and a Calbiochem Scholarship to the University of California at San Diego (PhD). After a brief period as an ICI Post-doctoral Fellow at the University of Sussex, Dennis changed career, and joined Deloitte Haskins & Sells as a trainee consultant, and where, for 12 years, he was a consulting partner. Dennis was subsequently an Executive Director with Goldman Sachs, a partner in Bossard Consultants, and Managing Director in the UK of SRI Consulting. Dennis now runs his own business, The Silver Bullet Machine Manufacturing Company Limited , which specialises in organizational creativity and innovation. Dennis participates in a number of academic programmes at institutions such as London Business School, the London School of Economics, the University of St Gallen, and London South Bank University.


PART I: FUNDAMENTALS ; 1. The crystalline state and its study ; 2. Vector analysis and complex algebra ; 3. Crystal systematics ; 4. Waves and electromagnetic radiation ; 5. Fourier transforms and convolutions ; 6. Diffraction ; PART II: DIFFRACTION THEORY ; 7. Diffraction by one-dimensional obstacles ; 8. Diffraction by a three-dimensional lattice ; 9. The contents of the unit cell ; PART III: STRUCTURE SOLUTION ; 10. Experimental techniques: sample preparation ; 11. Experimental techniques: data collection and analysis ; 12. The phase problem and the Patterson function ; 13. Molecular replacement ; 14. Solving the phase problem experimentally ; 15. Model-building and refinement ; 16. Complementary diffraction methods