Heredity under the Microscope

"The chromosome is at least as powerful an icon of heredity as DNA but so far has not held a central place in the historiography of twentieth-century life sciences. [Heredity under the Microscope] sets this record straight by directing its lense on the cytogenetic study of human chromosomes and the many contexts in which chromosome images came to matter. It opens fascinating new perspectives on the 'century of the gene' that go far beyond the earlier focus on the history of classical and molecular genetics." * British Society for the History of Science * "Heredity under the Microscope presents an accurate and sweeping view of the role that cytogenetics played, not only in the history of science after World War II but also as the means by which the current molecular view of the human chromosome was achieved. . . . [de Chadarevian's] is the first story of human cytogenetics told from the historical point of view. . . . The discussions are broad and comprehensive, with careful attention to details. With a few exceptions, they present all the main events occurring in the era of cytogenetics. . . . What is most remarkable to this reviewer, is that the longest section of the book is the notes (67 pp.). This section documents the multitude of sources for what is written in the five chapters. De Chadarevian spoke with a horde of researchers and listened to a great number of interviews with relevant cytogeneticists, and refers to an enormous amount of printed material. Everything in the five chapters is more than adequately supported, and the notes are a delight to read. . . . She deserves our thanks for putting together such a comprehensive survey of human cytogenetics." * FASEB Journal * "A fascinating read on the development of postwar human genetics. . . . This highly readable and impressive book demonstrates the overlapping concerns of science, medicine, law, and policy in the atomic age. De Chadarevian argues that the earlier microscopic research was central to the approach to studying human genetics. This book is a richly sourced survey of human cytogenetics and would be useful for undergraduate teaching." * Journal of the History of Ideas blog * "De Chadarevian's book fully meets its main goal: that of reintroducing chromosomes and cytogenetics into a still simplistic narrative of the history of the understanding of human heredity that traverses the twentieth century. . . . It is a most welcome development in the history of biology." * H-Sci-Med-Tech * "Images of the human chromosomes have enchanted scientists, inspired artists, and become symbols of human difference and pathology. In her engaging account, Soraya de Chadarevian deftly explores the visualization of these cellular 'colored bodies' and demonstrates their critical role in modern biology. The 'molecular revolution,' she suggests, was also a chromosomal revolution." -- M. Susan Lindee, University of Pennsylvania "De Chadarevian shows how much we have missed by looking at the history of biology since World War II as largely a history of how molecular geneticists cracked the genetic code. By focusing the lens on chromosomes, and their uses inside and outside the laboratory, her thorough yet elegant account exposes unexpected continuities, both with the eugenic past of heredity research and its genomic present." -- Staffan Muller-Wille, coauthor of The Gene: From Genetics to Postgenomics "Here we see most vividly how researchers debated the meanings and validity of visual evidence. Heredity Under the Microscope is a remarkable account of what was at stake in visualizing chromosomes." * Journal of the History of Biology * "The book is interesting, informative, and meticulously researched-a must-read for scientists and science studies scholars interested in the history of twentieth-century genetics. Chadarevian's writing style is accessible and engaging, which also makes the book suitable for non

Soraya de Chadarevian is professor in the Department of History and the Institute for Society and Genetics at the University of California, Los Angeles. She is the author and editor of numerous books including Models: The Third Dimension of Science and Designs for Life: Molecular Biology after World War II.

Introduction 1. Radiation and Mutation 2. Chromosomes and the Clinic 3. X and Y 4. Scaling Up 5. Of Chromosomes and DNA Epilogue Acknowledgments Note on Sources Notes Bibliography Index