Clinical Nephrotoxins

From the reviews of the third edition: "The purpose is to provide a guide with balanced and agreed-upon information about renal injury from drugs and chemicals. ... This book is a useful source of information for general clinicians, and nephrologists in particular. Intensivists, pharmacists, and investigators will also find it quite helpful. ... The book is well written, easy to read, and covers essential topics in a logical sequence. ... This book is particularly useful for nephrologists and I highly recommend it to medical and hospital libraries." (Aziz Chami, Doody's Review Services, February, 2009)

General.- Clinical relevance.- Drug-associated acute kidney injury in the intensive care unit.- Renal handling of drugs and xenobiotics.- Pharmacological aspects of nephrotoxicity.- Pharmacovigilance: from signal to action.- Urinary biomarkers and nephrotoxicity.- Toxin-induced immunological renal disease.- Cellular mechanisms of nephrotoxicity.- Animal models for the assessment of acute renal dysfunction and injury.- Renal cell culture models: Contribution to the understanding of nephrotoxic mechanisms.- Use of dialytic therapies for poisoning.- Specific Drugs.- Aminoglycosides and vancomycin.- Beta-lactam antibiotics.- Amphotericin B.- Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones.- Antiviral agents.- Analgesics and 5-aminosalicylic acid.- Non-steroidal anti-inflammatory drugs.- Gold salts, D-penicillamine and allopurinol.- Angiotensin I convert ing enzyme inhibitors and angiotensin II receptor antagonists.- Diuretics and alcohol ingestion.- Anticancer drugs.- Anesthetic agents.- Bisphosphonates and the kidney.- Proton pump inhibitors: acute interstitial nephritis and other renal effects.- Oral sodium phosphate bowel purgatives and acute phosphate nephropathy.- Illicit drug abuse and renal disease.- Nephrotoxicity of calcineurin and mTOR inhibitors.- Immunomodulators: interleukins, interferons, and IV immunoglobulin.- Imaging agents.- Lithium-associated kidney effects.- Oxalate.- Herbal remedies containing aristolochic acid and mushroom nephrotoxicity.- Environmental and Occupational Nephrotoxins.- Lead nephropathy.- Cadmium-induced renal effects.- Mercury-induced renal effects.- Organic solvents, silicon-containing compounds and pesticides.- Balkan nephropathy.- Nephrotoxins in Africa.- Paraphenylene diamine hair dye poisoning.- The Renal Failure Patient.- Trace metal disturbances in end-stage renal failure patients.- Smoking and the kidney.- Star fruit.- Drug dosage in renal failure.