Clinical Neurophysiology: Basis and Technical Aspects

"For individuals who are looking for a concise, but in depth, review of a specific neurophysiological technique, this is the text for you. Editors Levin and Chauvel provide a thoughtful examination of the technical characteristics of a variety of neurophysiological techniques. There do not appear to have been any corners cut in describing the technical aspects of each measurement procedure. As a whole, the volume represents a significant advancement to the rapidly evolving field of clinical neurophysiology." --Applied Neuropsychology-Adult, April 2020

Dr. Levin began his position at Cleveland Clinic in 1984 as a neurologist and currently serves in multiple capacities, including Chair of the Department of Neurology, Director of the Neuromuscular Center at the Neurological Institute, Program Director for neurophysiology and neuromuscular fellowships and Professor at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University. Twice awarded Teacher of the Year by the Neurology Department, Dr. Levin's specialties are electromyography and clinical neuromuscular diseases. Dr. Levin is a fellow of the American Academy of Neurology and of the American Association of Electrodiagnostic Medicine, and his been elected to membership in the American Neurological Association. He has held leadership positions in these and other professional associations and sits on the editorial board of Muscle and Nerve. The author of several books and many articles, Dr. Levin is also engaged in clinical research with interests ranging from the electrodiagnosis of radiculopathy and defects of neuromuscular junction transmission, to the treatment of polyneuropathy. After becoming an INSERM (Paris) researcher, Pr. Chauvel began his work in experimental and later clinical research into the mechanisms of the epilepsies. Under the mentorship of Talairach and Bancaud at Hopital Sainte-Anne, Paris, he developed SEEG (StereoElectroEncephalography) as a presurgical method in epilepsy surgery. His research work has been devoted to the neurophysiology of the epileptogenic zone, emergence of seizure clinical semiology in relation to intracerebral recording, and cerebral cortex physiology. He has promoted the concept of epileptogenic network over the classical epileptic focus idea, and opened new vistas in markers of the epileptogenic zone and pathophysiology of frontal epilepsies. Pr. Chauvel served as the Director of the SEEG Unit in Hopital Sainte-Anne in Paris (1986-1990), then Professor and Chairman of Neurology in Rennes (1990-1997) where he configured a new type of Epilepsy Unit including research, then Professor and Chairman of Clinical Neurophysiology and Director of the INSERM Institute of Systems Neuroscience in Marseille (1997-2014). In 2014, he relocated to the Epilepsy Center of the Cleveland Clinic, in order to promote the development of presurgical investigation using SEEG in North America. He is the author of 250 original articles in international journals and is a member of several Scientific and Medical Societies, both French and International. He has been elected as a Member of the Belgian Royal Academy of Medicine.

Section 1. Basic Physiological and Recording Concepts 1. Generation and propagation of the action potential 2. Volume conduction, waveform analysis, and near and far field potentials 3. Instrumentation for electrodiagnostic studies 4. Filtering of neurophysiological signals 5. Electrical safety

Section 2. EEG: Technologic Aspects and Basic Rhythms 6. EEG source localization 7. Adult EEG 8. Child EEG (and maturation) 9. Normal EEG variants 10. Ambulatory EEG 11. Video-EEG 12. High-resolution EEG 13. Magnetoencephalography for localizing and characterizing the epileptic focus

Section 3. Nerve Conduction Studies, Methods and Techniques 14. Nerve conduction studies: Basic concepts 15. F wave, A wave, H reflex, and blink reflex

Section 4. Needle Electromyography, Methods and Techniques 16. Needle electromyography: basic concepts 17. Normal and abnormal spontaneous activity 18. Normal and abnormal voluntary activity 19. Single fiber EMG

Section 5. Intra-operative Clinical Neurophysiology, MEP, SSEP 20. Electrocorticography and functional mapping 21. Spinal cord monitoring 22. Electrophysiological mapping for deep brain stimulation for movement disorders

Section 6. Sleep Physiology and Studies 23. Sleep-wake physiology 24. Practical aspects of actigraphy and approaches in clinical and research domains 25. Polysomnography 26. The Multiple sleep latency test

Section 7. Autonomic Nervous System: Basic and Technical Aspects 27. Basics of autonomic nervous system function 28. Autonomic testing, methods and techniques

Section 8. Auditory, Visual and Somatosensory Evoked Potentials 29. Cochlea and auditory nerve 30. Auditory brainstem response 31. The auditory and association cortex and language evaluation methods 32. Electroretinograms 33. The Electrooculogram 34. Visually evoked potentials 35. Somatosensory evoked potentials

Section 9. Cognitive Neurophysiology 36. Cognitive neurophysiology: event-related potentials 37. Transcranial magnetic stimulation