Handbook of Human Molecular Evolution (inbunden)
Inbunden (Hardback)
Antal sidor
2 Volume Set
John Wiley & Sons Inc
Illustrations (some col.), maps (some col.)
276 x 203 x 40 mm
2468 g
Antal komponenter
2 Hardbacks
Handbook of Human Molecular Evolution (inbunden)

Handbook of Human Molecular Evolution

2 Volume Set

Inbunden Engelska, 2008-08-29
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"This splendid compendium... will be the standard reference work for years to come: a handbook to browse, to consult, to look things up in, and to read with pleasure, wonder and post-Darwinian exhilaration.
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"This splendid compendium... will be the standard reference work for years to come: a handbook to browse, to consult, to look things up in, and to read with pleasure, wonder and post-Darwinian exhilaration." (Richard Dawkins) "This is a marvellous book ... For many years to come, these two volumes will be the starting point for anyone wishing to find out about virtually any subject relating to human genetics." (Human Genetics) "The publishers and editors deserve to be congratulated for publishing this major book which coincides with the 200th anniversary of the birth of Charles Darwin." (Genomic Medicine)

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Övrig information

David N. Cooper has been Professor of Human Molecular Genetics at Cardiff University since 1996. His research interests focus largely on molecular mechanisms of mutagenesis and genotype-phenotype relationships in a variety of different inherited disorders, population genetics, gene expression, cancer genetics, growth hormone genetics, and molecular evolution. He has written or co-authored Human Gene Mutation (1993), The Molecular Genetics of Haemostasis and Its Inherited Disorders (1994), Venous Thrombosis: From Genes to Clinical Medicine (1997), Human Gene Evolution (1999) and The Molecular Genetics of Lung Cancer (2005). He has also co-edited The Functional Analysis of the Human Genome (1995), Gene Therapy (1996), Neurofibromatosis Type 1: From Genotype to Phenotype (1998) and Fascioscapulohumeral Muscular Dystrophy: Clinical Medicine and Molecular Cell Biology (2004). He acted as Editor-in-Chief of the Nature Encyclopedia of the Human Genome (2003) and is currently Editor of the Genetics & Disease section of the Wiley Encyclopedia of Life Sciences. He has been European Editor of the journal Human Genetics since 1997 and Curator of the Human Gene Mutation Database (www.hgmd.org) since 1996. Hildegard Kehrer Sawatzki is a Senior Research Fellow in the Institute of Human Genetics, University of Ulm, Germany where she has been a group leader since 2000. She has published extensively in the field of molecular medicine and molecular evolution. Alongside her long-term work on the tumour predisposition syndrome, type 1 neurofibromatosis, she has developed a keen interest in the comparative analysis of the human, chimpanzee and macaque genomes in order to identify inter-species genetic differences, particularly those which are human-specific. She has characterized, at the molecular level, the microscopically-visible chromosomal differences between human and chimpanzee known as pericentric inversions. In addition, she has performed detailed genomic comparisons which have contributed to the identification of the hundreds of small submicroscopic inversions, insertions, deletions and copy number differences that are largely responsible for the genetic divergence of the primates. In 2007, she received the Merckle Research Prize for her work on evolutionary and disease-associated chromosomal breakpoints. David Cooper and Hildegard Kehrer-Sawatzki are the ELS section editors for Genetics & Disease and Evolution & Diversity of Life, respectively.


General Concepts in Evolutionary Genetics Views of Evolution James F Crow Evolution: Selectionist View Andreas Wagner Evolution: Neutralist View Andreas Wagner The Neo-selectionist Theory of Genome Evolution Giorgio Bernardi Fitness and Selection Brian Charlesworth Genetic Drift in Human Populations Andrew J Bohonak Heterozygosity Wen-Hsiung Li Effective Population Size Michael C Whitlock Population Differentiation: Measures Stefano Mona Giorgio Bertorelle Evolutionary Distance Wen-Hsiung Li Gene Trees and Species Trees Wen-Hsiung Li Homologous, Orthologous and Paralogous Genes Wen-Hsiung Li Evolution: Convergent and Parallel Evolution Caro-Beth Stewart Mutation, Adaptation and Natural Selection Genetic Variation: Polymorphisms and Mutations Alan F Wright Polymorphisms: Origins and Maintenance Kenneth M Weiss Molecular Evolution: Introduction David Penny Molecular Evolution: Overview Jan Klein Molecular Evolution: Genetics of Adaptation Michael Travisano Neutral Theory of Molecular Evolution Naoyuki Takahata Molecular Evolution: Nearly Neutral Theory Tomoko Ohta Molecular Evolution: Rates Lindell Bromham Molecular Evolution: Patterns and Rates Lindell Bromham Nucleotide Substitution: Rate of Wen-Hsiung Li Synonymous and Nonsynonymous Rates Soojin Yi Mutational Change in Evolution Dan Graur Mutations and New Variation: Overview Mark O Johnston Single-base Mutation Dan Graur Mutation Rate Bertram Muller-Myhsok Mutation Rates: Evolution David Metzgar Spectrum of Mutations in the Human Genome Inferred by Single Nucleotide Polymorphisms Zhao Zhongming Mutational Biases Lev Y Yampolsky Arlin Stoltzfus Mutations: Dating Roberto Colombo Diffusion Theory Gil McVean Molecular Clocks in Mammals Wen-Hsiung Li Kateryna D Makova Molecular Clocks Andrew Peter Martin Purifying Selection: Action on Silent Sites R Nielsen H Akashi Selection against Amino Acid Replacements in Human Proteins Sankar Subramanian Identifying Regions of the Human Genome that Exhibit Evidence for Positive Selection Ryosuke Kimura Jun Ohashi Positive Selection on Genes in Humans as Compared to Chimpanzees Margaret A Bakewell Jianzhi Zhang Selection Operating on Protein-coding Genes in the Human Genome Diogo Meyer Eugene E Harris Selective and Structural Constraints Austin L Hughes Substitution Matrices Stephen F Altschul Fixation Probabilities and Times Sarah P Otto Michael C Whitlock Genetic Code: Evolution Edward N Trifonov Codon Usage in Molecular Evolution Richard L Grantham Linkage Disequilibrium Peter JP Croucher Recombination and Human Genetic Diversity Chris CA Spencer Comparison of Rates and Patterns of Meiotic Recombination between Human and Chimpanzees Jan Freudenberg Rapid Evolution of Genes on the Human X-chromosome Erika M Kvikstad Kateryna D Makova Evolutionary and Population Genetics Gene Flow, Haplotype Patterns and Modern Human Origins Alan R Templeton HapMap Project Bryan J Traynor Andrew Singleton Migration Guido Barbujani Nonrandom Mating Dennis H O'Neil Human Population Stratification and its Assessment by Microarray Genotyping Marc Bauchet Sequence Alignment Julie D Thompson Olivier Poch Sequence Similarity Jaap Heringa Phylogenetics Wen-Hsiung Li Phylogenetic Footprinting Wyeth W Wasserman Wynand Alkema Molecular Phylogeny Reconstruction Sudhir Kumar Alan Filipski Evolutionary Distance: Estimation Masatoshi Nei Jianzhi Zhang Coalescent Theory Simon Tavare Stationary Allele Frequency Distributions Bruce Rannala Developmental Evolution Susan Lindsay Morphological Diversity: Evolution Graham Budd Male-driven Evolution Hans Ellegren Coevolution: Molecular Ronald M Adkins Concerted Evolution Daiqing Liao Sociobiology, Evolutionary Psychology and Genetics Patrick Bateson Are Humans Still Evolving? Floyd A Reed Human Evolution Hominids: Molecular Phylogenetics Ulfur Arnason Morgan Kullberg Human Evolution: O