The Design and Manufacture of Medicines
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Preface ....................................................................... vii
Contributors ............................................................. ix
Acknowledgements .................................................. xiii
What is 'pharmaceutics'?......................................... xv
Kevin M.G. Taylor and Michael E. Aulton
1. Design of dosage forms.................................. 1
Peter York
2. Dissolution and solubility ............................. 13
Michael E. Aulton
3. Properties of solutions ................................... 30
Michael E. Aulton
4. Surfaces and interfaces ................................... 39
Graham Buckton
5. Disperse systems.............................................. 50
David Attwood
6. Rheology........................................................... 81
Christopher Marriott
7. Kinetics ............................................................. 101
Gareth R. Williams and John P. Malkinson
8. Solid-state properties .................................... 114
Graham Buckton
9. Particle size analysis ..................................... 126
Kevin M.G. Taylor
10. Particle size reduction and size
separation....................................................... 143
Michael E. Aulton
11. Mixing............................................................. 156
Andrew M. Twitchell
12. Powder flow................................................... 172
Michael E. Aulton
13. Fundamentals of microbiology................... 184
Lara-Marie Barnes and Geoffrey W. Hanlon
14. Pharmaceutical applications of
microbiological techniques.......................... 208
Lara-Marie Barnes and Norman A. Hodges
15. Action of physical and chemical agents
on microorganisms....................................... 229
Lara-Marie Barnes, Geoffrey W. Hanlon and
Norman A. Hodges
16. Principles of sterilization ............................. 247
Susannah E. Walsh, Katie Laird and Jean-Yves
Maillard
17. Sterilization in practice ................................ 257
Jean-Yves Maillard, Katie Laird and Susannah E.
Walsh
18. Introduction to biopharmaceutics.............. 275
Marianne Ashford and Kevin M.G. Taylor
19. Gastrointestinal tract e physiology and
drug absorption............................................. 279
Marianne Ashford and Kevin M.G. Taylor
20. Bioavailability e physicochemical,
dosage form and formulation factors ........ 297
Marianne Ashford, Kevin M.G. Taylor and
Hala M. Fadda
21. Assessment of biopharmaceutical
properties ....................................................... 320
Marianne Ashford and Kevin M.G. Taylor
22. Dosage regimens ........................................... 343
Soraya Dhillon and Nkiruka Umaru
23. Pharmaceutical preformulation .................. 360
Simon Gaisford
24. Solutions .................................