Cytokine Gene Polymorphisms in Multifactorial Conditions (inbunden)
Inbunden (Hardback)
Antal sidor
illustrated ed
CRC Press Inc
Gorczynski, Reginald M./Bidwell, Jeffrey L.
1 Halftones, black and white; 45 Tables, black and white; 45 Illustrations, black and white
262 x 185 x 32 mm
1035 g
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Cytokine Gene Polymorphisms in Multifactorial Conditions (inbunden)

Cytokine Gene Polymorphisms in Multifactorial Conditions

Inbunden Engelska, 2006-06-01
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The literature on cytokine genetics is vast, so vast that it is now practically beyond the time or logistical constraints of most scientists to successfully keep pace with it. A compilation of the latest research, Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphisms in cytokine genes. It discusses haplotype structures and linkage disequilibrium patterns in cytokine gene loci; functional biological effects of polymorphisms; and genetic associations with disease. The book documents polymorphisms in the most important cytokine genes, or gene clusters, and their biological and genetic effects in a multitude of distinct multifactorial conditions. Unique to this book are the "disease-centered" chapters examining the role of cytokine gene polymorphisms in a multitude of multifactorial conditions. The conditions include autoimmune or chronic inflammatory diseases, cardiovascular disease, infectious diseases, and longevity. "This section is a real tour de force" (Grant Gallagher and Michael F. Seldin, March 2006). Broadening the understanding of the effect of genetic variations on human immune responses, the organization, scope, and content of this book make it a valuable and easily accessible resource. The book integrates genetic, immunological, and clinical information and will serve as a reference for novice and expert geneticists, immunologists, cell biologists and clinicians. It is a must for everyone involved in, or planning, cytokine genetics or immunogenetics studies.
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"As this volume so capably demonstrates, genetic variation in cytokines, the messengers of the immune system, and their receptors is now recognized as playing an important role in disease susceptibility and outcome...This book is a timely anthology of knowledge, techniques as well as informed speculation...The chapters in this book represent an excellent and timely means of addressing questions related to the study of cytokine gene polymorphisms and will serve as an important reference work.." - From the foreword by Grant Gallagher and Michael F. Seldin, Editors, "Genes and Immunity", March 2006


GENERAL CONCEPTS The Biology of Cytokines:General Principles, Properties and Lessons from Animal Models, D. Agnello and M. Gadina Genetics of Multifactorial Disorders, J.R. Oksenberg and J.D. Rioux Statistical Approaches to Analysis of Polymorphisms in Multifactorial Conditions, A. Goris and M. de Andrade Introduction to Integrated Bioinformatic Resources for Cytokine Genetics Research, R. Lazarus Cytokine Gene Nucleotide Sequence Alignments, J. Bidwell SNP Genotyping Techniques, P.-Y. Kwok CYTOKINE GENE POLYMORPHISMS The IL1 Cluster, T. Pessi, C. Eklund, A. Raitala, and M. Hurme IL-2 Biology and Polymorphisms in Multifactorial Conditions, F. Matesanz, M. Fedetz, and A. Alcina The Chromosome 5q23.1 -q31.1 Cluster of Cytokines, T. Laitinen IL10, R. Lazarus The IL19 Subfamily of Cytokines, S. Koks, K. Kingo, E. Vasar, and H. Silm The IFNG -IL26 -IL22 Cytokine Gene Cluster, K. Vandenbroeck and A. Goris TNF-a Polymorphisms and Disease, R.M. Gorczynski and I. Boudakov Macrophage Migration Inhibitory Factor (MIF), Z. Alourfi, D.W. Ray, and R. Donn Polymorphisms of Chemokines and Their Receptors, B. Puissant, C. Combadiere, and E. Lavergne POLYMORPHIC CYTOKINE NETWORKS IN MULTIFACTORIAL CONDITIONS Asthma and Atopy, J. Karjalainen, M. Virta, K. AEdjers, and M. Hurme Common Rheumatic Diseases, R. Kilding and A.G. Wilson Systemic Lupus Erythematosus, S. D 'Alfonso Sjoegren 's Syndrome, M. Pertovaara Multiple Sclerosis, O.H. Kantarci and B.G. Weinshenker Type 1 and 2 Diabetes, R. Bergholdt and F. Pociot Psoriasis, S. Koks, K. Kingo, E. Vasar, and H. Silm Diseases of the Gastrointestinal Tract, T. Hoehler Pulmonary Fibrosis, B. Yucesoy and M.I. Luster Atherosclerosis, G. Candore, S. Vasto, G. Colonna-Romano, D. Lio, M. Carusob, I.M. Rea, and C. Caruso Longevity, I.M. Rea, G. Candore, L. Cavallone, F. Olivieri, M. Cardelli, C. Franceschi, G. Colonna-Romano, D. Lio, O.A. Ross, and C. Caruso AIDS, A. Vasilescu, H. Do, and J.-F. Zagury Tropical Infectious Diseases, T. Quirico-Santos, A.M. Da-Cruz, C. Fernandez Kubelka, J. Lannes-Vieira, and M. Ozorio Moraes Suseptibility to Infection and Severe Disease in Schistosomiasis, V. Arnaud and C. Chevillard Index