Endothelin Receptors (inbunden)
Fler böcker inom
Inbunden (Hardback)
Antal sidor
CRC Press Inc
7 Tables, black and white
242 x 161 x 22 mm
649 g
Antal komponenter
Contains 21 Hardbacks
Endothelin Receptors (inbunden)

Endothelin Receptors

From the Gene to the Human

Inbunden Engelska, 1995-05-01
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Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans. This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.
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Recensioner i media

"This book is recommended as an addition to the libraries of institutions and individual researchers actively studying the physiological and/or pathophysicological role of endothelin." - J. Med. Chem., 1996, 39(3)


Introduction: Endothelin Receptors, E.H. Ohlstein and R.R. Ruffolo, Jr. Endothelin Receptor Subclassification, E.H. Ohlstein, P. Nambi, and R.R. Ruffolo, Jr. Molecular Biology of Endothelin Receptors, D.J. Bergsma, N. Elshourbagy, and C. Kumar Signal Transduction Processes Involved in Endothelin-Mediated Responses, P. Nambi, C. Kumar, and E.H. Ohlstein Endothelin Receptor Antagonists, J.D. Elliott, M.A. Lago, and C.E. Peishoff Functions Mediated by Peripheral Endothelin Receptors, E.H. Ohlstein, S. Douglas, D.P. Brooks, D.W.P. Hay, G.Z. Feuerstein, and R.R. Ruffolo, Jr. Endothelin in the Central Nervous System, R.N. Willette, G.Z. Feuerstein, and F.C. Barone The Role of Endothelin in Human Disease: Implications and Potential Therapeutic Intervention, D.K. Jorkasky, D.W.P. Hay, and M.I. Freed Index