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Format: Inbunden (Hardback)
Språk: Engelska
Antal sidor: 304
Utgivningsdatum: 1995-05-01
Förlag: CRC Press Inc
Medarbetare: Hollinger, Mannfred A. (series ed.)
Illustrationer: 7 Tables, black and white
Dimensioner: 242 x 161 x 22 mm
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Antal komponenter: 1
Komponenter: Contains 21 hardbacks
ISBN: 9780849359385

Endothelin Receptors

Name: Endothelin Receptors
Price: 6336.00 SEK
Availability: InStock
Author: Jr Ruffolo Robert R
ISBN: 9780849359385

From the Gene to the Human

av Jr Ruffolo Robert R

Inbunden, Engelska, 1995-05-01

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Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans. This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.

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Apoptosis in Health and Disease

Jr Ruffolo Robert R, Frank Walsh

The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expand...

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"This book is recommended as an addition to the libraries of institutions and individual researchers actively studying the physiological and/or pathophysicological role of endothelin." - J. Med. Chem., 1996, 39(3)

Robert R. Ruffolo Jr.

Introduction: Endothelin Receptors, E.H. Ohlstein and R.R. Ruffolo, Jr.Endothelin Receptor Subclassification, E.H. Ohlstein, P. Nambi, and R.R. Ruffolo, Jr.Molecular Biology of Endothelin Receptors, D.J. Bergsma, N. Elshourbagy, and C. Kumar Signal Transduction Processes Involved in Endothelin-Mediated Responses, P. Nambi, C. Kumar, and E.H. OhlsteinEndothelin Receptor Antagonists, J.D. Elliott, M.A. Lago, and C.E. PeishoffFunctions Mediated by Peripheral Endothelin Receptors, E.H. Ohlstein, S. Douglas, D.P. Brooks, D.W.P. Hay, G.Z. Feuerstein, and R.R. Ruffolo, Jr.Endothelin in the Central Nervous System, R.N. Willette, G.Z. Feuerstein, and F.C. BaroneThe Role of Endothelin in Human Disease: Implications and Potential Therapeutic Intervention, D.K. Jorkasky, D.W.P. Hay, and M.I. FreedIndex