De som köpt den här boken har ofta också köpt The Anxious Generation av Jonathan Haidt (inbunden).
Köp båda 2 för 3389 krDr. David Glocker has worked in the fields of thin film deposition and plasma treatment for over 35 years. He spent fourteen years at the Eastman Kodak Company, where he led a group responsible for research on PVD coatings and coating processes and methods for the plasma modification of polymers. In 1993 he founded Isoflux Incorporated to manufacture cylindrical magnetron sputtering cathodes and develop coating processes employing that technology. Several medical device manufacturers now use Isoflux cathodes and related patents in both research and manufacturing. Dr. Glocker is an inventor or co-inventor on 32 US patents as well as a number of foreign counterparts and is the author of numerous articles and presentations. He recently retired from Isoflux and consults. Dr. Shrirang Ranade, Technical Development Leader at Genentech, Inc., a member of the Roche Group, has spent over 15 years working within large medical device and Pharma (F. Hoffman-La Roche, Johnson & Johnson and Boston Scientific) in the field of biomaterials, coatings and drug delivery devices. He obtained a Bachelor of Engineering from the University of Poona, a Master of Science from the University of Manchester Institute of Science & Technology and later a Ph.D. in Polymer Science from the University of Connecticut. Through his career he has been involved in research and development of medical devices for combination products in several forms: coronary drug eluting stents, balloon catheters, sinuplasty devices, orthopaedic scaffolds, biodegradable coatings and lately an implantable ocular drug delivery system.
Preface xxi Part 1 Introduction 1 1 Historical Perspectives on Biomedical Coatings in Medical Devices 3 M. Hendriks and P.T. Cahalan 1.1 Introduction 4 1.2 Improving Physical Properties of Biomaterials: Hydrophilic, Lubricious Coatings 7 1.3 Modulating Host-Biomaterial Interactions: Biologically Active Coatings 7 1.4 Bioinert Coatings Redressed: Nonfouling Coatings 15 1.5 Future Biomedical Coatings 16 References 18 Part 2 Coating Applications 27 2 Antimicrobial Coatings and Other Surface Modifications for Infection Prevention 29 Marc W. Mittelman and Nimisha Mukherjee 2.1 Introduction 29 2.2 Genesis of Device-Related Infections 35 2.3 Antimicrobial Coatings 38 2.4 Non-Eluting Antimicrobial Surfaces 49 2.5 Coating and Surface Modification Technologies 53 2.6 Regulatory Considerations 57 2.7 Future Challenges 58 References 61 3 Drug Delivery Coatings for Coronary Stents 75 Shrirang V. Ranade and Kishore Udipi 3.1 Introduction 75 3.2 Polymer Coatings for DES 81 3.3 Biostable (Non-Bioabsorbable) Polymers 86 3.4 Bioabsorbable Polymers 99 3.5 Concluding Remarks 103 References 104 4 Coatings for Radiopacity 115 Scott Schewe and David Glocker 4.1 Principles of Radiography 115 4.2 Use of Radiopaque Materials in Medical Devices 116 4.3 Radiopaque Fillers 117 4.4 Types of Radiopaque Fillers 117 4.5 Other Radiographic Materials and Coating Systems 121 4.6 Radiopaque Coatings by Physical Vapor Deposition 122 4.7 Challenges in Producing Radiopaque Coatings Using PVD 124 4.8 Gold Radiopaque Coatings 125 4.9 Tantalum Radiopaque Coatings 126 4.10 Summary 129 References 130 5 Biocompatibility and Medical Device Coatings 131 Joe McGonigle, Thomas J. Webster, and Garima Bhardwaj 5.1 Introduction 131 5.2 Challenges with Medical Devices 134 5.3 Examples of Products Coated to Improve Biocompatibility 148 5.4 Types of Biocompatible Coatings 157 5.5 Commercialization 170 5.6 Summary 172 References 172 6 Tribological Coatings for Biomedical Devices 181 Peter Martin 6.1 Introduction 181 6.2 Hard Thin Film Coatings for Implants 187 6.3 Binary Carbon-Based Thin Film Materials: Diamond, Hard Carbon and Amorphous Carbon 194 6.4 Progress of DLC, ta-C and a-C:H Films for Hip and Knee Implants 200 6.5 Wear-Resistant Coatings for Stents and Catheters 208 6.6 Wear-Resistant Coatings for Angioplasty Devices 210 6.7 Scalpel Blades and Surgical Instruments 211 6.8 Multifunctional, Nanostructured, Nanolaminate, and Nanocomposite Tribological Materials 211 References 222 Part 3 Coating and Surface Modification Methods 233 7 Dip Coating 235 Donald M. Copenhagen 7.1 Description and Basic Steps 235 7.2 Equipment and Coating Application 236 7.3 Coating Solution Containers 237 7.4 Coating Parameters and Controls 238 7.5 Role of Solution Viscosity 240 7.6 Coating Problems 241 7.7 Process Considerations 244 8 Inkjet Technology and Its Application in Biomedical Coating Bogdan V. Antohe, David B. Wallace, and Patrick W. Cooley 247 8.1 Introduction 247 8.2 Inkjet Background 248 8.3 Equipment Used 260 8.4 Capabilities 268 8.5 Limitations and Ways around Them 280 8.6 Manufacturing Advantages and Future Directions 293 8.7 Conclusions 299 References 300 9 Direct Capillary Printing in Medical Device Manufacture 309 William J. Grande 9.1 Introduction 309 9.2 Fundamental Elements of Direct Capillary Printing 320 9.3 Practical Operational Considerations 337 9.4 Manufacturing Considerations 349 9.5 Medical Device Examples 352 9.6 Conclusions 367 Acknowledgments 369 References 369 10 Sol-Gel Coating Methods in Biomedical Systems 373 Bakul C. Dave 10.1 Introduction 374 10.2 Overview of Sol-Gel Coatings in Biomedical Systems 377 10.3 The Sol-Gel Process 381 10.4 Coating Methods and Processes 385 10.5 Factors influencing Coatings Characteristics/Performance 390 10.6 Summary and Concluding Remarks 394 Re