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Atlas of AI
The Biology and Therapeutic Application of Mesenchymal Cells
2 Volume Set4249
The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.
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Fler böcker av Kerry Atkinson
Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.
Contributors, xxvii Editor s Preface, xxxv Section I: An overview of mesenchymal stem cells and mesenchymal stromal cells 1 The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome, 3 Kerry Atkinson 2 The nomenclature of mesenchymal stem cells and mesenchymal stromal cells, 8 Armand Keating Section II: The isolation and ex vivo expansion of mesenchymal stromal cells 3 The isolation and expansion of mesenchymal stromal cells from bone marrow, 13 Celena F. Heazlewood 4 The biology and clinical applications of mesenchymal stromal cells derived from human gestational tissues, 24 Celena F. Heazlewood 5 Human placenta-derived mesenchymal stem/stromal cells: fetal and maternal origins and critical parameters for ex vivo expansion, 32 Rebecca A. Pelekanos and Varda S. Sardesai Section III: The cellular and molecular biology of mesenchymal stromal cells 6 Epigenetic regulation of mesenchymal stem/stromal cell growth and multipotentiality, 41 Sarah Elizabeth Hemming, Dimitrios Cakouros, and Stan Gronthos 7 Biological changes in human mesenchymal stromal cells during monolayer culture, 58 Marietta Herrmann and Jennifer J. Bara 8 The effect of three-dimensional aggregates on the biology of mesenchymal stromal cells, 75 Yijun Liu, Ang-Chen Tsai, Xuegang Yuan, and Teng Ma 9 Cell cell signaling pathways that regulate mesenchymal stromal cell differentiation, 91 Leah Etheridge, Rebecca A. Mason, Fatima Saleh, and Paul Genever 10 Regulation of mitochondrial transport in mesenchymal stromal cells, 104 Shravani Mukherjee, Naveen K. Bhatraju, Tanveer Ahmad, and Anurag Agrawal 11 The regulation of adipogenesis from adipose-derived stem/stromal cells, 114 Lin Chen and Lei Liu 12 Modulation of osteogenic differentiation in mesenchymal stromal cells, 131 Sean Gaynard, Jessica Hayes, and Mary Murphy 13 The role of glycogen synthase kinase-3 inhibitors on bone remodeling, 148 K. Jane Escott and Patrick J. O Shea 14 Early molecular events during in vitro chondrogenesis, 167 Tommy A. Karlsen, Rune B. Jakobsen, and Jan E. Brinchmann 15 The role of the extracellular matrix in the differentiation of mesenchymal stromal cells, 191 Peishun Shou, Qing Chen, and Yufang Shi 16 Effects of hypoxic culture on bone marrow multipotent mesenchymal stromal cells: from bench to bedside, 196 Shih-Chieh Hung 17 The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells, 208 Adisri Charoenpanich, Josephine Bodle, and Elizabeth Loboa 18 The evolving concept of mesenchymal stromal cells in regenerative medicine: from cell differentiation to secretome, 222 F.G. Teixeira, A. Pires, S.C. Serra, N. Sousa, and A.J. Salgado 19 The secretome of mesenchymal stem/stromal cells undergoing chondrogenic differentiation and those undergoing osteogenic or adipogenic differentiation, 236 Beatriz Rocha, Francisco J. Blanco, and Cristina Ruiz-Romero 20 Mesenchymal stromal cell extracellular vesicles/exosomes, 250 Ronne Wee Yeh Yeo, Ruenn Chai Lai, and Sai Kiang Lim 21 Role of tunneling nanotube crosstalk with distressed cardiomyocytes in controlling the heart repair potential of mesenchymal stromal cells, 264 Anne-Marie Rodriguez and Meriem Mahrouf-Yorgov 22 The preferential homing of mesenchymal stromal cells to sites of inflammation, 286 Catherine Sullivan 23 The role of chemokines in mesenchymal stromal cell homing to sites of inflammation, including infarcted myocardium, 314 Shan Wang and Yaojiong Wu 24 Live cell imaging and single cell tracking of mesenchymal stromal cells in vitro, 323 James A. Cornwell, Maria Z. Gutierrez, Richard P. Harvey and Robert E. Nordon 25 The role of mesenchymal stem/stromal cells in angiogenesis, 347 Annelies Bronckaers and Ivo Lambrichts 26 The relationship between mesenchymal stromal cells and endothelial cells, 366 Seyed Mahdi Nassiri and Reza Rahbarghazi 27 The radiore