Food Safety

IAN C. SHAW is Professor of Toxicology at the University of Canterbury, Christchurch, New Zealand. His CV includes academic positions in biochemistry, toxicology, and applied biology, as well as experience as a clinical scientist and a member of various international government advisory bodies on food safety.

Acknowledgements xiv 1 Introduction 1 Introduction 1 A brief history of food safety 1 Evolution of cellular protection mechanisms 2 2 Food Risk 13 Introduction 13 What is risk? 14 Measuring hazard 16 Determining risk 18 Acceptable risk 23 Risk versus benefit 26 Risk perception 27 The precautionary principle 30 Food risk assessment 31 Relative risk and risk ranking 33 Risk management 33 Risk communication 36 Quantitative risk assessment 36 Take home messages 45 Further reading 45 3 Bacteria 46 Introduction 46 The discovery of bacteria 47 The biology of bacteria 52 The bacterial ecology of food 61 Human bacterial pathogens on food 62 Gastroenteritis 63 Food-borne pathogenic bacteria 63 Take home messages 101 Further reading 102 4 Viruses 103 Introduction 103 The discovery of viruses 103 The biology of viruses 105 Diseases caused by viruses and mechanisms of viral transmission 108 Other food-borne viruses 115 Take home messages 116 Further reading 116 5 Parasites 117 Introduction 117 What are parasites? 117 Flatworms Platyhelminthes 118 Tapeworms Cestodes 118 Flukes Trematodes 121 Nematodes 124 Protozoa 130 Take home messages 140 Further reading 140 6 Bovine Spongiform Encephalopathy (BSE) 141 Introduction 141 The history of BSE 141 The epidemiology of BSE in England 142 Spongiform encephalopathies 143 Prions 143 The symptoms of BSE 145 BSE cases in the UK 146 BSE transmission and the origins of PrPSC 146 The risk to human consumers of BSE beef nvCJD 149 The politics of BSE and implications for food safety worldwide 153 BSE incidence around the world 153 Take home messages 154 Further reading 155 7 Chemical Contaminants 156 Introduction 156 Pesticides 157 Insecticides 164 Herbicides 185 Fungicides 187 Veterinary medicines 192 Growth promoting chemicals 203 Fertilisers 208 Natural environmental chemicals 210 Non-agricultural environmental pollutants 213 Residues monitoring programmes 217 Dietary intake and risk to human consumers 218 Take home messages 219 Further reading 219 8 Natural Toxins 220 Introduction 220 Why produce natural toxins? 221 Natural toxins in the human food chain 222 Plant toxins 224 Mycotoxins 237 Phytohaemagglutinins in beans 241 Bacterial toxins 243 Phytoestrogens 243 Take home messages 243 Further reading 243 9 Endocrine Disrupting Chemicals 244 Introduction 244 The first observations of xenoestrogens effects 245 Estrogen receptors ERs 246 Molecular requirements for estrogenicity 247 Estrogens are present in both males and females 247 Xenoestrogens 248 Population level effects of exposure to xenoestrogens 261 The positive health effects of xenoestrogens 264 Take home messages 265 Further reading 265 10 Genetically Modified Food 266 Introduction 266 A brief introduction to nucleic acids, genetics and molecular biology 267 Nucleic acids 267 Converting the genetic code into a protein 268 The history of GM crops 271 The tools of the genetic engineer 272 Glyphosate-resistant crops 274 Insect-protected crops BT toxin 275 GM crops with enhanced flavour or nutritional properties 276 What happens if humans eat GM crops or foods made from them? 277 Changed biochemistry in GM crops 278 What is the effect of eating DNA and RNA? 278 GM animals 279 Take home messages 279 Further reading 279 11 Colours, Flavours and Preservatives 280 Introduction 280 Food colours 282 Flavours 290 Preservatives 305 Take home messages 319 Further reading 319 12 Food Irradiation 320 Introduction 320 Different types of radioactivity 321 How irradiation kills cells 323 The history of food irradiation 324 The effect of radiation on microorganisms 325 How is food irradiated? 326 The effects of irradiation on food chemistry 326 The effects of irradiation on vit