Pathology of the Developing Mouse

"Pathology of the Developing Mouse: A Systematic Approach is a much anticipated addition to the veterinary pathology reference literature. It is a fairly inexpensive textbook that will be useful for anyone who uses mice in developmental research. Detailed, easy-to-follow experimental protocols are described throughout the text. In many cases, there are multiple options for procedures with pros and cons discussed for each. Each chapter contains excellent tables, diagrams, and photographs and ends with a complete reference list. Although there is a growing volume of information on mouse developmental biology in the literature and on the Internet, the authors of this book have done a great job of creating a synopsis of this information that can be easily used by anyone working or training in mouse pathology or developmental biology." Stephen M. Griffey, DVM, PhD, University of CaliforniaDavis, in JAVMA

Brad Bolon, DVM, MS, PhD, is a Diplomate of both the American College of Veterinary Pathologists (DACVP) and the American Board of Toxicology (DABT) as well as a Fellow of both the Academy of Toxicological Sciences (FATS) and the International Academy of Toxicologic Pathology (FIATP). He is currently an associate professor in the Department of Veterinary Biosciences, College of Veterinary Medicine and also the associate director of the Comparative Pathology and Mouse Phenotyping Shared Resource, Comprehensive Cancer Center at the Columbus campus of The Ohio State University (OSU). His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, neonates, and placentas) and toxicologic neuropathology.

INTRODUCTION. The Case for Developmental Pathology and Developmental Pathologists. FUNDAMENTALS OF MOUSE DEVELOPMENTAL BIOLOGY. Essentials of Mouse Genetics and Nomenclature. Essential Terminology for Mouse Developmental Pathology Studies. Anatomy and Physiology of the Developing Mouse and Placenta. Teratogens and Teratogenic Mechanisms in Mouse Developmental Pathology. EXPERIMENTAL METHODS IN MOUSE DEVELOPMENTAL PATHOLOGY. Principles of Experimental Design for Mouse Developmental Pathology Studies. Necropsy Sampling and Data Collection for Studying the Anatomy, Histology, and Pathology of Mouse Development. Clinical Pathology Analysis in Developing Mice. Histotechnological Processing of Developing Mice. Localization of Gene Expression in Developing Mice. Protein Localization in Developing Mice. Quantitative Morphological Assessment in Mouse Developmental Pathology Studies. Ultrastructural Evaluation of Developing Mice. Three-Dimensional Imaging in Mouse Developmental Pathology Studies. ANALYTICAL PRACTICES FOR MOUSE DEVELOPMENTAL PATHOLOGY. Pathology of the Developing Mouse from Conception to Weaning. Pathology of the Placenta. Mouse Developmental Pathology Assessments in High-Throughput Phenogenomic Facilities. A Statistical Analysis Primer for Mouse Developmental Pathology Studies. COMMON ABBREVIATIONS IN MOUSE DEVELOPMENTAL PATHOLOGY STUDIES. INDEX.