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A Guide to Obesity and the Metabolic Syndrome
Origins and Treatment
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George A. Bray, M.D., MACP, MACE is a Boyd Professor at the Pennington Biomedical Research Center of Louisiana State University in Baton Rouge, Louisiana, and Professor of Medicine at the Louisiana State University Medical Center in New Orleans. He was the first Executive Director of the Pennington Biomedical Research Center in Baton Rouge, a post he held from 1989 to 1999. He is a Master in both the American College of Physicians and the American College of Endocrinology. Dr. Bray founded the North American Association for the Study of Obesity (NAASO now The Obesity Society), and he was the founding editor of its journal, Obesity Research, as well as co-founder of the International Journal of Obesity and the first editor of Endocrine Practice, the official journal of the American College of Endocrinologists. Dr. Bray has received many awards during his medical career. They have included the Johns Hopkins Society of Scholars, Honorary Fellow, American Dietetic Association, Joseph Goldberger Award from the American Medical Association, the McCollum Award from the American Society of Clinical Nutrition and the Osborne-Mendel Award from the American Society of Nutritional. Dr. Bray has also received the TOPS Award from NAASO, the Weight Watchers Award, the Bristol-Myers Squibb Mead Johnson Award in Nutrition and the Stunkard Lifetime Achievement Award. During the past 40 years, Dr. Bray has authored or coauthored more than 1,700 publications, ranging from peer-reviewed articles to reviews, books, book chapters and abstracts.
Origins Origins of Obesity in the Scientific Era-AD 1500 to the Present Introduction Sixteenth Century Seventeenth Century Eighteenth Century Nineteenth Century Twentieth Century: An Age of Specialization in Science and Medicine Definition, Measurement, and Prevalence Introduction Definitions Describing Body Composition Methods of Measuring Body Weight and Body Fat Instruments Used to Measure Body Composition Instrumental Methods for Measuring Visceral Fat Body Fat through the Life Span Body Fat and Body Energy Stores Criteria for the Metabolic Syndrome Prevalence of Obesity Metabolic Syndrome Conclusion Genetic, Metabolic, and Social Origins of Obesity Introduction Genetic Factors Epigenetic and Intrauterine Imprinting Environmental Agents and Obesity: An Epidemiologic Approach Regulation of Body Fat: A Homeostatic Model of Energy Regulation Effects of Obesity on Health and Metabolism Introduction Historical Context for the Risks of Overweight as a Disease Costs of Obesity The Pathology of Obesity The Pathophysiology of Central and Total Fat Benefits and Potential Risks of Weight Loss Treatment Prevention, Evaluation, and Introduction to Treatment Introduction Prevention of Obesity Introduction to Treatment Criteria for Evaluating Outcomes Lifestyle, Diet, and Exercise: Cognitive Solutions Introduction to Cognitive Solutions for Weight Loss Lifestyle Change: A Cognitive Solution Diet: A Cognitive Solution Physical Activity: A Cognitive Solution Cognitive Strategies to Maintain Weight Loss Medications for Obesity Brief History of the Drug Treatment for Obesity Mechanisms that Modulate Food Intake and Energy Expenditure: The Basis for Pharmacological Interventions Drugs Approved by the Food and Drug Administration for the Treatment of Obesity Drugs Approved for Other Uses that Have Effects on Body Weight Combinations of Drugs Used for Weight Loss Drugs in Late Stages of Clinical Evaluation Concepts for Antiobesity Drugs in Earlier Stages of Development Complementary and Herbal Medicine Surgery for Obesity Introduction Rationale for Surgical Intervention for Obesity Indications Contraindications Bariatric Surgery for Pediatric Patients Effectiveness of Surgical Procedures Mechanisms for Weight Loss Benefits from Bariatric Surgery Complications Other Procedures Postscript-Obesity in the Twenty-First Century Lessons We Have Learned in this Book Where Do We Go in the Twenty-First Century?