Cellular Senescence and Tumor Suppression (inbunden)
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Format
Inbunden (Hardback)
Språk
Engelska
Antal sidor
272
Utgivningsdatum
2009-12-17
Upplaga
2010 ed.
Förlag
Springer-Verlag New York Inc.
Medarbetare
Adams, Peter D. (ed.), Sedivy, John M. (ed.)
Illustratör/Fotograf
20 schwarz-weiße und 5 farbige Abbildungen 1 4-color insert 6 schwarz-weiße Tabellen
Illustrationer
6 Tables, black and white; XIII, 272 p. With 1 4-color insert.
Dimensioner
231 x 157 x 20 mm
Vikt
545 g
Antal komponenter
1
Komponenter
1 Hardback
ISBN
9781441910745

Cellular Senescence and Tumor Suppression

av Peter D Adams, John M Sedivy
Inbunden,  Engelska, 2009-12-17
2233
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As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.
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Innehållsförteckning

Introduction: J Sedivy. Section 1. Senescence signals. 1. Telomere biology and biochemistry: 1, J Karlseder; 2, T de Lange; 3, L Harrington. 2. Short telomere-driven senescence: 1, F d'Adda di Fagagna; 2, N Sharpless; 3, V Bohr. 3. Oncogene-induced senescence: 1, M Serrano; 2, J Bartek; 3, G, Ferbeyre. 4. Stress-induced senescence: 1, T Finkel; 2, V Gorbunova; 3, E Hara; 4, F Ishikawa. 5. Modulation of senescence by extracellular growth factors: 1, P Adams. Section 2. The senescent phenotype. 6. The senescent phenotype and its evolution: 1, J Campisi. 7. Chromatin structure in senescent cells: 1, E Medrano; 2. M Narita. 8. A comparison of senescence in mouse and human cells: 1, C Greider; 2, M Blasco. Section 3. The physiological consequences of senescence. 9. Tumor suppression: 1, G Peters; 2, N Sharpless; 3, S Chang. 10. Tissue aging: 1, L Rudolph; 2, A Trumpp. 11. Senescence as a potential therapeutic tool: 1, C Schmitt; 2, S Lowe.

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