List of Contributors.- Section A. Applied Physiology.- 1 Measurement and Control of Cardiac Output.- Cardiac Output at Rest and on Exercise.- Intrinsic Properties of Heart Muscle.- Coronary Blood Flow.- Assessment of the Heart as a Pump.- Cardiac Output during Exercise and Cardiac Failure.- 2 The Systemic and Pulmonary Circulations.- Functions of the Circulation.- Functional Organization of the Circulation.- The Systemic Circulation.- The Pulmonary Circulation.- Implications of Circulatory Physiology in Critical Care.- 3 Cardiopulmonary Interactions.- I. The Physiology of Cardiopulmonary Interactions Transmural Pressure.- Myocardial Function.- Cardiac Function: Left Heart Versus Right Heart.- The Cardiac Fossa.- Hemodynamic Effects of Ventilation.- Hemodynamic Effects of Changes in Lung Volume.- Hemodynamic Effects of Changes in Intrathoracic Pressure.- II. Clinical Aspects of Cardiopulmonary Interactions.- Negative Changes in Intrathoracic Pressure: Spontaneous Inspiration.- Positive Changes in Intrathoracic Pressure: Spontaneous Expiration.- Positive-Pressure Ventilation: Concepts.- Modes of Mechanical Ventilation.- 4 Pulmonary Ventilation and Gas Exchange.- Ventilation.- Diffusion.- Perfusion.- Ventilation-Perfusion Ratios.- 5 Oxygen Transport and Consumption.- Determinants of Tissue Oxygen Tension.- Classification of Hypoxia.- Recognition of Tissue Hypoxia.- Venous Oxygen Tension as an Index of Tissue Hypoxia.- Tissue Oxygen Extraction.- Physiological Versus Pathological Oxygen Supply Dependence.- 6 Mediator Systems of Lung Injury.- Humoral Mediators.- Cellular Mediators.- Conclusions.- 7 Fluid and Electrolyte Balance.- Distribution of Body Water.- Relationship Between Plasma and Interstitial Fluid.- Relationship of Intracellular to Extracellular Interstitial Fluid.- Water and Electrolyte Balance.- 8 Acid-Base Disturbances.- Buffering.- Respiratory Control of Acid-Base.- Renal Control of Acid-Base.- Metabolic Control of Acid-Base.- Interpretation of Acid-Base Data.- Respiratory Acidosis.- Respiratory Alkalosis.- Metabolic Acidosis.- Metabolic Alkalosis.- 9 Mechanisms of Haemostasis.- Physiology of Haemostasis.- The Investigation of Haemostatic Disorders.- 10 Cerebral Blood Flow and Metabolism.- Cerebral Blood Flow.- Cerebral Metabolism.- Conclusions.- 11 Defense Strategies Against Hypoxia.- Normal and Abnormal Pasteur Effects.- Oxygen Regulators and Oxygen Conformers.- Metabolite Signals Sustaining Stable Respiration in Oxygen Regulators.- Loss of Standard Electron Transfer System-Glycolysis Integration in Oxygen Conformers.- Oxygen as a Signal Controlling Oxygen Conformity.- Oxygen Management Strategies in Diving Seals.- 12 Humoral and Cell-Mediated Immunity.- The Normal Immune System.- Immunity and Infection.- Pathological Consequences of Immunity.- Immunodeficiency.- 13 Regulation of Body Temperature.- Thermal Equilibrium.- Physiological Measurement of Thermal Strain.- Effects of Heat.- Effects of Cold.- Mathematical Models of Thermoregulation in Man.- Central Nervous Control.- Thermoreception.- Fever.- Effects of Drugs on Thermoregulation.- 14 The Physiology of the Newborn.- Cardio-respiratory Adaptation.- Blood Pressure in the Neonate.- Thermoregulation in the Neonate.- Renal Function.- Neonatal Jaundice.- Pain in the Neonate.- Section B. Cardiovascular Disorders.- 15 Cardiopulmonary Resuscitation.- The Therapeutic Approach to CPR.- The Heart and CPR.- The CNS and CPR.- Monitoring the Brain during CPR.- The Brain After CPR.- Management of Brain Dysfunction and Damage.- Judging the Effectiveness of CPR: Stage 1 Success or Failure.- Pulmonary Function.- Drug Therapy.- Inotropic Agents.- Metabolic Acidosis.- Antidysrhythmic Agents.- Electrolyte Disturbances.- Routes of Drug Administration.- Cannulation of Vessels.- Fluid Expansion.- Artificial Pacemaking.- Abandoning CPR.- Complications of Chest Compression.- Effectiveness of CPR: Stage 2 Success or Failure.- Appendix 1: Mobile Equipment for CPR Trolley.- 16 The Cardiac