GLUCAGON: Its Role in Physiology and Clinical Medicine

I. Ontogeny of the A Cell and the Morphology of Glucagon Release.- Ontogeny of the Entero-Pancreatic A Cells and of Glucagon Production.- Morphologic Study of Glucagon Release.- II. Biosynthesis, Nature and Sites of Origin of Pancreatic Glucagon and of Glucagon-Like Immunoreactive Materials.- Glucagon Biosynthesis in Anglerfish Islets: Identification of a 4,900 Dalton Metabolic Conversion Intermediate.- High Molecular Weight Glucagons from Avian Islets and Fetal Bovine Pancreas.- Assessment of Glucagon Immunoreactivity in Plasma.- Quantification of Plasma Glucagon Immunoreactive Components in Normal and Hyperglucagonemic States.- Circulating Glucagon Components: Significance in Health and Disease.- Plasma Immunoreactive Glucagon in Depancreatized Animals.- Heterogeneity of Gut Glucagon-Like Immunoreactivity (GLI).- Glucagon-Like Materials in Porcine and Rat Intestinal Mucosa.- Immunoreactive Glucagon in the Salivary Glands of Man and Animal.- Role of the Submaxillary Gland and of the Kidney in the Hyperglucagonemia of Eviscerated Rats.- Glucagon and the Kidney.- III. Secretion of Pancreatic Glucagon.- The Role of Calcium in Glucagon Secretion.- The Versatile Role of Calcium in Glucagon Release.- Interrelationship of Calcium and Somatostatin in the Secretion of Insulin and Glucagon.- Dynamics and Interrelationships of In Vitro Secretion of Glucagon and Insulin.- Effects of Insulin on the Glucagon Release, Glucose Utilization and ATP Content of the Pancreatic A Cells of the Guinea Pig.- Effect of Vasoactive Intestinal Peptide (VIP) and Gastric Inhibitory Peptide (GIP) on Insulin and Glucagon Release by Perifused Newborn Rat Pancreas.- The Role of the Autonomic Nervous System in Glucagon Secretion.- IV. Mode of Action of Glucagon.- Interactions of Hepatocyte Membrane Receptors with Pancreatic and Gut Glucagon.- Glucagon, Insulin and their Hepatic Receptors: An Endocrine Pattern Characterizing Hepatoproliferative Transitions in the Rat.- Reexamination of the Second Messenger Hypothesis of Glucagon and Catecholamine Action in Liver.- Guanyl Nucleotide Regulation of the Liver Glucagon-Sensitive Adenylyl Cyclase System.- A Peptide Inhibitor of Glucagon-Responsive Adenylate Cyclase in Liver.- Modulation of Nuclear Protein Kinase Activity by Glucagon.- Combined Influence of Insulin and Glucagon Upon Hepatocytes in Rats with Liver Loss or Viral Injury.- V. Metabolic Effects and Physiologic Role of Glucagon.- Insulin and Glucagon (Pancreatic and Extrapancreatic) Interactions and the Regulation of Glucose Turnover in Physiology and in the Diabetic State.- Regulation of Hepatic Gluconeogenesis by Glucagon in the Rat.- Hormonal Regulation of Hepatic Protein Metabolism in the Rat In Vivo. Control of Glucagon.- The Role of Glucagon in Amino Acid Homeostasis.- The Roles of Glucagon and Cyclic Adenosine 3?,5?-Monophosphate in the Regulation of Lipid Biosynthesis.- Lowering of Plasma Lipids, the Major Effect of Repeated Glucagon Administration in Rats.- Glucagon and Lipoprotein Regulation in Man.- Metabolic Fuels in the Embryo and the Newborn.- Role of the Insulin/Glucagon Ratio in the Changes of Hepatic Metabolism during Development of the Rat.- Glucose Homeostasis in the Newborn.- VI. Role of Glucagon in Diabetes Mellitus, in Prediabetes and in Other Disease States.- New Concepts in Glucagon Physiology.- The Issues Related to Abnormal A Cell Function in Diabetes Mellitus.- On the Causes and Consequences of Abnormal Glucagon Secretion in Human Diabetes Mellitus.- The Effects of Exogenously Induced Hyperglucagonemia in Insulin-Treated Diabetics.- The Nature of the A Cell Abnormality in Human Diabetes Mellitus.- The Nature of Hyperglucagonemia in Diabetes Mellitus.- Glucagon in Diabetic Coma.- Glucagon Metabolism in Potential Diabetes Mellitus. Studies of Discordant Twins and Patients After Myocardial Infarction.- Tolbutamide: Stimulator and Suppressor of Glucagon Secretion.- Effect of Long Term Sulfonylurea Therapy on Glucagon Levels in Maturity