Screening for Biological Response Modifiers: Methods and Rationale (häftad)
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Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
194
Utgivningsdatum
2011-11-18
Upplaga
Softcover reprint of the original 1st ed. 1985
Förlag
Springer-Verlag New York Inc.
Medarbetare
Fidler, Isaiah J. / Oldham, R.K.
Illustrationer
XIV, 194 p.
Dimensioner
234 x 156 x 11 mm
Vikt
304 g
Antal komponenter
1
Komponenter
1 Paperback / softback
ISBN
9781461296249

Screening for Biological Response Modifiers: Methods and Rationale

av James E Talmadge, Isaiah J Fidler, R K Oldham
Häftad,  Engelska, 2011-11-18
1550
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The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations stimulated a search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for "screening" drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6).
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Innehållsförteckning

1. Biologic and Technical Considerations for the Design of Screening Procedures for the Assessment of Biological Response Modifiers.- 2. Procedures for Preclinical Screening of Biological Response Modifying Agents.- 3. Preclinical Evaluation of Individual Biological Response Modifiers.- 4. Clinical Correlations.

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