Handbook of Anticancer Pharmacokinetics and Pharmacodynamics (inbunden)
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Format
Inbunden (Hardback)
Språk
Engelska
Antal sidor
836
Utgivningsdatum
2014-01-11
Upplaga
2nd ed. 2014
Förlag
Springer-Verlag New York Inc.
Medarbetare
Rudek, Michelle A. (ed.), Chau, Cindy H. (ed.), Figg, William D. (ed.), McLeod, Howard L. (ed.)
Illustratör/Fotograf
46 illus in color XVIII, 900P145 illus 99 schwarz-weiße und 46 farbige Abbildungen
Illustrationer
46 Illustrations, color; 99 Illustrations, black and white; IX, 836 p. 145 illus., 46 illus. in colo
Dimensioner
273 x 190 x 50 mm
Vikt
2177 g
Antal komponenter
1
Komponenter
1 Hardback
ISBN
9781461491347
Handbook of Anticancer Pharmacokinetics and Pharmacodynamics (inbunden)

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Inbunden Engelska, 2014-01-11
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There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
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"...an invaluable overview of the experimental and clinical processes that lead to anticancer drugs, creating a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials." - Tumori

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Övrig information

Dr. Michelle Rudek received her BS in Pharmacy from the University of Pittsburgh and her dual Pharm.D., Ph.D. from Virginia Commonwealth University in a joint clinical pharmacology/oncology program with the National Cancer Institute. Dr. Rudek joined Johns Hopkins University in 2001 and is currently an Associate Professor of Oncology and Director of the Analytical Pharmacology Core Laboratory. Her research program is focused on clinical pharmacology with a focus on early phase drug development and special populations including AIDS malignancy and organ dysfunction. Dr. Cindy H. Chau received her BS in Molecular, Cell, and Developmental Biology from UCLA and her Pharm.D. and Ph.D. (in Molecular Pharmacology and Toxicology) dual degrees from the University of Southern California School of Pharmacy as a National Institutes of Health (NIH) predoctoral fellow. She was the recipient of the NIH National Research Service Award. Dr. Chau completed a postdoctoral fellowship at the NIH, joining the National Cancer Institute in 2004 and is currently a research scientist within the Medical Oncology Branch, Center for Cancer Research. Dr. William Douglas Figg received his B.S. (Hon) from Georgetown College, his B.S. in Pharmacy from Samford University and his Pharm.D. from Auburn University. He completed his clinical pharmacy internship at the University of Alabama at Birmingham Hospital and his fellowship in drug development at the University of North Carolina-Chapel Hill. Dr. Figg also received an M.B.A. degree from a combined program at Columbia University and London Business School. He joined the Medical Oncology Branch, National Cancer Institute, National Institutes of Health in 1992. He has patented more than 80 new anticancer agents and four pharmacogenetic tests. Dr. Howard McLeod is Fred Eshelman Distinguished Professor and Director, UNC Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill. Dr. McLeod holds appointments in the UNC Schools of Pharmacy and Medicine, the Carolina Center for Genome Sciences, and the Lineberger Comprehensive Cancer Center. Dr McLeod is chair of the NHGRI eMERGE network external scientific panel and is a member of the FDA committee on Clinical Pharmacology. He is a member of the NIH NHGRI Advisory Council. Since 2002, Dr. McLeod has been vice chair for Pharmacogenomics for the NCI clinical trials cooperative group CALGB/ALLIANCE, overseeing the largest oncology pharmacogenomics portfolio in the world.

Innehållsförteckning

Molecular Targets Annunziata, Christina M. (et al.) Preclinical Screening for New Anticancer Agents Burger, Angelika M. (et al.) Natural Product Screening McKee, Tawnya C. (et al.) Defining the Starting Dose: Should It Be mg/kg, mg/m Gao, Bo (et al.) Phase 0 Trials in Oncology Kummar, Shivaani (et al.) Phase I Trials in Oncology: Design and Endpoints Glen, Hilary (et al.) Quantitative Analytical Methods: Development and Clinical Considerations Gardner, Erin R. Validation and Control of Bioanalytical Methods Karnes, H. Thomas (et al.) Anticancer Clinical Pharmacology Overview Dandamudi, Uday B. (et al.) Pharmacokinetic Modeling Li, Jing (et al.) Pharmacometrics Brar, Satjit S. (et al.) Pharmacodynamic Modeling Bauer, Kenneth S. (et al.) Protein Binding Sparreboom, Alex (et al.) Metabolism (Non-CYP Enzymes) Jamieson, David (et al.) Pharmacogenomics and Cancer Therapy: Somatic and Germline Polymorphisms Patel, Jai N. (et al.) Cytochrome P450 Ando, Yuichi Polymorphisms in Genes of Drug Targets and Metabolism Bohanes, Pierre (et al.) DNA Repair: ERCC1, Nucleotide Excision Repair, and Platinum Resistance Reed, Eddie (et al.) Drug Interactions Rivory, Laurent P. ABC Transporters: Involvement in Multidrug Resistance and Drug Disposition Massey, Paul R. (et al.) Solute Carriers Ho, Richard H. (et al.) High-Throughput Platforms in Drug Metabolism and Transport Pharmacogenetics English, Bevin C. (et al.) Intrathecal Administration Kilburn, Lindsay B. (et al.) Microdialysis Combest, Austin J. (et al.) Regional Drug Delivery for Inoperable Pulmonary Malignancies Schrump, David S. Blood-Brain Barrier and CNS Malignancy Balmanoukian, Ani (et al.) Radiation and Altering Clinical Pharmacology Smart, DeeDee (et al.) Therapeutic Cancer Vaccines: An Emerging Approach to Cancer Treatment Madan, Ravi A. (et al.) Recombinant Immunotoxins Kreitman, Robert J. Monoclonal Antibodies Bai, Shuang (et al.) Clinical Pharmacology in Pediatrics Tagen, Michael (et al.) Clinical Pharmacology in the Older Adult Slattum, Patricia W. (et al.) Organ Dysfunction Trials: Background, Historical Barriers, Progress in Overcoming Barriers, and Suggestions for Future Trials Kummar, Shivaani (et al.) Drug Formulations: How these Affects Anticancer Drug Lagas, Jurjen S. (et al.) Nanotechnology in Cancer Janat-Amsbury, Margit M. (et al.) Imaging in Drug Development Kurdziel, Karen A. (et al.) Exposure-Response Relationships of Anticancer Agents: Application in Drug Development and Drug Label Rahman, Atiqur The Role of Phase III Trials in Modern Drug Development Murphy, Janet E. (et al.) Clinical Trial Designs for Approval of New Anticancer Agents Chadha, Manpreet K. (et al.) Clinical Pharmacogenetics Sachidanandam, Kamakshi (et al.)