Vaccine Design (häftad)
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Häftad (Paperback / softback)
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Softcover reprint of the original 1st ed. 1997
Springer-Verlag New York Inc.
Allison, Anthony C. (ed.), Gregoriadis, Gregory (ed.), McCormack, Brenda (ed.)
IX, 209 p.
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1 Paperback / softback
Vaccine Design (häftad)

Vaccine Design

The Role of Cytokine Networks

Häftad Engelska, 2013-08-14
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During the last decade or so vaccine development has been facilitated by rapid ad- vances in the molecular and cell biology ofthe immune system. This has laid the foundations of a new generation of vaccines exemplified by subunit vaccines produced through gene cloning and by synthetic peptides mimicking small regions ofproteins on the outer coat ofvi- ruses. However, as subunit and peptide vaccines are only weakly or non-immunogenic, there is areal need for strategies to improve their potency. This book contains the proceedings of the 5th NATO Advanced Studies Institute (ASI), "Vaccine Design: The Role of Cytokine Networks," held at Cape Sounion Beach, Greece, during 24 June-5 July 1996 and deals in depth with the role ofbasic immunology in the regulation of immunity and vaccine design. Special emphasis is given to the use of cyto- kines in conjuction with vaccines with the aim ofimproving their potency or the use ofvac- cines designed to improve cytokine production. We express our appreciation to Dr. J.-L. Virelizier and Dr. G. Kollias for their cooperation in planning the ASI and to Mrs. Concha Perring for her excellent production ofthe manuscripts. The ASI was held under the sponsor- ship of NATO Scientific Affairs Division and generously co-sponsored by SmithKline Beecham Pharmaceuticals (Philadelphia). Financial assistance was also provided by Connaught Laboratories Ltd. (Ontario), Pasteur Merieux (Marcy I 'Etoile), Biochine (Siena), Help SA (Athens), and Avanti Polar Lipids Inc. (Birmingham, USA).
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`This book should be very valuable to anyone interested in the basic design of vaccine strategies or the preclinical evaluation of novel vaccines and adjuvants.' Doody's Journal `I have little doubt that this book will become a standard reference for future development of vaccine formulations.' European Journal of Pharmaceutics and Biopharmaceutics Vaccine Design.

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The Role of Cytokines in the Action of Immunological Adjuvants; A.C. Allison. The Role of Tumour Necrosis Factor in Lymphoid Tissue Formation and Function; M. Pasparakis, et al. Dendritic Cells and Cytokines; J.M. Austyn. Control of HIV Entry and Transcription, as a Possible Mechanism of the Antiviral Effects of T Lymphocytes in HIV Infection; J.-L. Virelizier, et al. Development of an Influenza-IscomTM Vaccine; J. Cox, et al. Development of Parainfluenza Virus and Respiratory Syncytial Virus Subunit Vaccines; M. Ewasyshyn, et al. Mucosal Vaccines: Perspectives on the Development of Anti-H.Pylori. Vaccines; P. Ghiara. A Single Treatment with Adjuvant Stimulates Thl-like Cytokines and Downregulates Th2-Mediated Primary and Secondary Allergic Responses; D.E. Scott, B. Golding. Induction of IL-12 Secretion and Enhanced Surface Expression of B7.1/B7.2 and ICAM-1 in Human Monocytes Activated by the Vaccine Carrier Brucella Abortus: Correlaton with in Vivo Generation of Cellular Immune Responses; H. Golding, et al. The Potential use of Different Vaccination Protocols to Tailor Cytokine Profiles; E. Comoy, et al. Modulation of Cytokine Responses by Iscoms and Iscom-Matrix; M. Villacres-Eriksson, et al. Vaccines and Vaccine Delivery Systems: Experience with HSV, Influenza and Mucosal Routes of Immunisation; R. Jennings, et al. 7 Additional Articles. Index.