The Neurochemical Basis of Autism (häftad)
Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
295
Utgivningsdatum
2014-12-13
Upplaga
2010 ed.
Förlag
Springer-Verlag New York Inc.
Medarbetare
Blatt, Gene J. (ed.)
Illustrationer
XV, 295 p.
Antal komponenter
1
Komponenter
1 Paperback / softback
ISBN
9781489981974
The Neurochemical Basis of Autism (häftad)

The Neurochemical Basis of Autism

From Molecules to Minicolumns

Häftad Engelska, 2014-12-13
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Withtherecentlyperceivedincreaseinincidenceofautismandtherealizationthat "autism"mayactuallybe"autisms"withsubsetsofaffectedindividuals,researchers have been pursuing the possibility that there may be multiple etiologies for the disorder.Althoughmostautismstudieshavefocusedongeneticsandadvancedn- roimaging,thereisapaucityofresearchaimedatdeterminingtheneurochemical basisofautism.Identifyingcoreneuralsubstratesorkeybiomarkersisessentialto understandingthemechanisticbasisthatmayinpartunderlie"autisms."Alterations inmolecules,proteins,receptors,andsynapticelementsaresomeofthecontrib- ingsubstratesthatcouldresultinaltereddevelopmentalprocesses,changedsynaptic function,andaberrationsinconnectivity.Itisnowapparentthatmultiplebrainareas are affected in autism, and neuropathological defects have been described within corticalandsubcorticalnetworks.Althoughrecentprogresshasbeenmadeinid- tifyingsomeofthegenesthatmayunderliethedisorder,muchattentionhasalso beengiventoepigeneticand/orenvironmentalfactorsthatmaycontributetosubsets ofautisticindividuals. The contributors to this book were hand selected because of their expertise in their respective ?elds. Individually each chapter presents a unique perspective into the clinical, developmental, neurochemical, and/or physical chemical basis of autism. The contributing authors summarize current research ?ndings in their respective areas and also present novel ideas and propose hypotheses and p- sible mechanisms that may be operative during development and the potential consequencesofhavingdefectsinspeci?cmolecules,receptors,orgenes. Thesubtitle"FromMoleculestoMinicolumns"wasinsertedbecauseofmuch recent attention given to alterations in the basic organization of mini- or mic- columns of neurons in cerebral cortical areas in autism. These especially include prefrontalcorticalareasthatundergoanovergrowthduringearlypostnataldevel- mentinmanyindividualswithautism.Tothisend,theworldrenownedDr.Alan Peters,theneuroanatomistthatoriginallydescribedmini-ormicro-columnaror- nizationinthecerebralcortex,wasrecruitedtowriteachapterinthisbookgiving hisexpertperspectiveontheissueinautism. The book begins with highly respected clinician, Dr. Margaret L. Bauman, DirectoroftheLADDERSclinicintheBostonarea,withaclinicalandmedicalp- spectiveofautismdiscussingetiologies,clinicalpresentation,earlyidenti?cation, vii viii Preface advancementsinmedicalcare,andassociateddisorders. Inthechapter"TheMale Prevalence in Autism Spectrum Disorders: Hypotheses on its Neurobiological Basis",ItalianresearchersDrs.FlavioKellerandLilianaRutapresentneuroch- ical hypotheses as the basis for the predominance of male prevalence in autism discussing the possible roles of estrogen, testosterone, oxytocin, and vasopressin in the organization of brain circuits and hemispheric specialization. Psychiatrist Dr. Ricardo Vella relates neuropathologies in autism, in the limbic and cereb- lar regions, to speci?c behaviors and presents a developmental perspective and hypotheses regarding emotional and attachment behaviors in autistic individuals.
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Fler böcker av Gene J Blatt

  • Neurochemical Basis of Autism

    Gene J Blatt

    A perceived rise in autism worldwide has led to a dramatic increase in autism research. This is a uniquely interdisciplinary text that presents the latest findings regarding the physiological, neuropathological, neurochemical and clinical elements...

Recensioner i media

From the reviews: "In this much needed book aimed at researchers, scientists and clinicians, Blatt (anatomy and neurobiology, Boston U) assembles 15 chapters that focus on the neurochemical basis of autism a little studied topic. ... Lay abstracts and summaries at the end are aimed at parents, siblings and caregivers." (SciTech Book News, June, 2010)

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Innehållsförteckning

Autism Spectrum Disorders: Clinical and Medical Perspectives.- The Male Prevalence in Autism Spectrum Disorders: Hypotheses on its Neurobiological Basis.- Neuroanatomical-Behavioral Correlates in Autism: A Working Hypothesis.- The Morphology of Minicolumns.- The Developmental Neuropathology of Autism.- Understanding Alterations During Human Brain Development with Molecular Imaging: Role in Determining Serotonin and GABA Mechanisms in Autism.- Glutamic Acid Decarboxylase (GAD) as a Biomarker of GABAergic Activity in Autism: Impact on Cerebellar Circuitry and Function.- Epigenetic Dysregulation of 15q11-13 GABAA Receptor Genes in Autism.- Cholinergic Component of Autism Spectrum Disorder.- Oxytocin and Autism.- The Role of the Noradrenergic System in Autism Spectrum Disorders.- Oxidative Stress in Autism and Its Implications for Dopamine-Stimulated Phospholipid Methylation.- Neuroligins and Neurexins: Synaptic Bridges Implicated in Autism.- The Neurophysical Chemistry of Autism: Postulates from Intelligence Modeling.- Pharmacological Treatment of Autism.