Cyclic Peptide Design (inbunden)
Inbunden (Hardback)
Antal sidor
1st ed. 2019
Humana Press Inc.
Goetz, Gilles (ed.)
Bibliographie 54 schwarz-weiße und 82 farbige Abbildungen
82 Tables, color; 80 Illustrations, color; 58 Illustrations, black and white; X, 332 p. 138 illus.,
254 x 178 x 24 mm
785 g
Antal komponenter
1 Hardback
Cyclic Peptide Design (inbunden)

Cyclic Peptide Design

Inbunden Engelska, 2019-05-28
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This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature's cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field. Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields.
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1. Design Principles for Intestinal Permeability of Cyclic Peptides Alan M. Mathiowetz 2. Strategies to Enhance Metabolic Stabilities Bhavesh Khatri, Venkateswara Rao Nuthakki, and Jayanta Chatterjee 3. Designing Cell-Permeable Macrocyclic Peptides George Appiah Kubi, Patrick G. Dougherty, and Dehua Pei 4. Computational Methods for Studying Conformational Behaviors of Cyclic Peptides Fan Jiang and Hao Geng 5. Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein-Protein Interactions Fergal Duffy, Nikunj Maheshwari, Nicolae-Viorel Buchete, and Denis Shields 6. Design of Cyclic Peptides as Protein Recognition Motifs Ye Che 7. Design and Synthetic Strategies for Helical Peptides Licheng Tu, Dongyuan Wang, and Zigang Li 8. Click Chemistry for Cyclic Peptides Drug Design Adel Ahmed Rashad 9. Frontier between Cyclic Peptides and Macrocycles Philipp Ermert, Anatol Luther, Peter Zbinden, and Daniel Obrecht 10. Building upon Nature's Framework: Overview of Key Strategies towards Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles Maria-Jesus Blanco 11. Design of Oxytocin Analogs Kazimierz Wisniewski 12. DNA-Encoded Macrocyclic Peptide Library Zhengrong Zhu, Alex Shaginian, LaShadric C. Grady, Christopher P. Davie, Kenneth Lind, Sandeep Pal, Praew Thansandote, and Graham L. Simpson 13. Peptide Display Technologies Anthony Pitt and Zeke Nims 14. Discovery of Functional Macrocyclic Peptides by Means of the RaPID System Christos Tsiamantas, Manuel E. Otero-Ramirez, and Hiroaki Suga 15. Genetic Selections with SICLOPPS Libraries: Towards the Identification of Novel Protein-Protein Interaction Inhibitors and Chemical Tools Francisco Castillo and Ali Tavassoli