Antimicrobial Resistance in Bacteria from Livestock and Companion Animals

REVIEW 1 In this era of "superbugs" and rising antimicrobial resistance, Antimicrobial Resistance in Bacteria from Livestock and Companion Animals is a valuable resource to better understand the contribution of animal-derived pathogens to this growing public health crisis. The use of antimicrobial drugs in animal populations is not without controversy; the underlying concern, of course, is that antimicrobial use in animals results in illness and death in humans. This text does not seek to specifically condemn or exonerate. Instead, it provides a comprehensive account of a very complicated topic, delving into the nuances needed to understand the what, where, when, and why of antimicrobial resistance in companion animals and livestock. The text begins with a historical overview of the discovery of antimicrobial drugs and a detailed characterization of the indications for and regulation of their use in veterinary medicine. Salient technical issues are discussed, including antimicrobial susceptibility testing in veterinary pathogens, diagnostic methods for detecting antimicrobial resistance, and licensing of antimicrobial drugs. Overviews of the mechanisms of resistance to antimicrobial agents, including antibiotics, metals, and biocides, provide context to the main substance of the text: an exhaustive report of current antimicrobial resistance in a wide range of pathogens of veterinary and medical importance. The text closes with a look into the future of mitigating antimicrobial resistance in veterinary and production settings through monitoring, surveillance, and antimicrobial stewardship. Antimicrobial Resistance in Bacteria from Livestock and Companion Animals presents a wealth of information and is a critical resource for anyone who studies, treats, or is affected by antimicrobial resistance in domesticated animals or the food products that come from them. Contributing authors are globally renowned experts in the field who have composed thoughtful and insightful accounts that generally walk the line between technically thorough and accessible to a broad audience. Whether one is interested in a specific pathogen or in policy to mitigate antimicrobial resistance, this text offers a comprehensive review of the increasingly urgent topic that is antimicrobial resistance in animal-derived pathogens. -Laurel Redding, University of Pennsylvania, Kennett Square, Pennsylvania, USA REVIEW 2 Description This is a comprehensive collection of research works on the current status of antimicrobial resistance in bacteria infecting livestock and companion animals. This is an updated version of a book published in 2006, Antimicrobial Resistance in Bacteria of Animal Origin, Aarestrup (ASM Press). Purpose The purpose is to highlight the current situation of antimicrobial resistance in bacteria of animal origin. The book provides the latest information about the molecular mechanisms of antibiotic resistance and the methods to monitor antibiotic resistance and describes the future strategies for better management and control of multidrug resistant bacterial pathogens. Audience This is a valuable resource for veterinary and medical students, clinicians, microbiologists, researchers working in the field of antimicrobial resistance, and policymakers. The chapters are written by researchers who are experts in their fields. Features The emergence and spread of multidrug-resistant bacteria are serious problems for both human and animal health. Millions of human and animal deaths occur every year as a result of the serious diseases caused by multidrug-resistant bacterial pathogens. This book covers all major bacterial pathogens such as Staphylococcus, Streptococcus, Enterococcus, E. coli, Campylobacter, Bordetella, Pseudomonas, and Mycoplasma species. In addition to the traditional information on antibiotic resistance, the book describes recent developments in each area. For example, it includes a compreh

Stefan Schwarz is Prof. Dr at Department of Veterinary Medicine at the Freie Universitat, Berlin Lina Cavaco is a Veterinarian and Researcher Technical University of Denmark. Jianzhong Shen is Associate Professor with Tenure, Dept. of Drug Discovery & Development, Auburn University, Harrison School of Pharmacy, USA. Frank Moller Aarestrup is Professor, Head of Research Group at National Food Institute, Research Group for Genomic Epidemiology at Technical University, Denmark.

1. History and current use of antimicrobial drugs in veterinary medicine John F. Prescott 2. Antimicrobial Susceptibility Testing of Bacteria of Veterinary Origin; Breakpoints Jeffrey L. Watts, Michael T. Sweeney and Brian V. Lubbers 3. New and Molecular Methods for the Detection of Antimicrobial Resistance (including MALDI-TOF, NGS, DNA array) Muna F. Anjum, Ea Zankari, and Henrik Hasman 4. Mechanisms and Transmission of Bacterial Resistance to Antimicrobial Agents Engeline van Duijkeren et al. 5. Resistance to Metals Used in Agricultural Production Christopher Rensing et al. 6. Resistance to Biocides in Bacteria Jean-Yves Maillard 7. Antimicrobial Resistance among Staphylococci of Animal Origin Stefan Schwarz et al. 8. Antimicrobial Resistance in Streptococcus spp. Marisa Haenni, Agnese Lupo and Jean-Yves Madec 9. Antimicrobial Resistance in Enterococcus spp. Carmen Torres et al. 10. Antimicrobial Resistance in Rhodococcus equi Steve Giguere, Londa J. Berghaus, and Jennifer Willingham-Lane 11. Antimicrobial Resistance in Listeria spp. Laura Luque-Sastre et al. 12. Antimicrobial Resistance in Nontyphoidal Salmonella Patrick F. McDermott, Shaohua Zhao, and Heather Tate 13. Antimicrobial Resistance in Escherichia coli Laurent Poirel et al. 14. Antimicrobial Resistance in Campylobacter spp. Zhangqi Shen et al. 15. Antimicrobial Resistance in Pasteurellaceae of Veterinary Origin Geovana B. Michael, Janine Bosse, and Stefan Schwarz 16. Antimicrobial Resistance in Bordetella bronchiseptica Kristina Kadlec, and Stefan Schwarz 17. Antimicrobial Resistance in Pseudomonas spp. and Acinetobacter spp. Agnese Lupo, Marisa Haenni, and Jean-Yves Madec 18. Antimicrobial Resistance in Corynebacterium spp., Arcanobacterium spp., and Trueperella pyogenes Andrea T. Fessler and Stefan Schwarz 19. Antimicrobial Resistance in Stenotrophomonas spp. Yang Wang et al. 20. Antimicrobial Resistance in Mycoplasma spp. Anne V. Gautier-Bouchardon 21. Antimicrobial Resistance in Clostridium spp., Brachyspira spp., and other Anaerobes Marie Archambault and Joseph Rubin 22. Antimicrobial Resistance in Leptospira, Brucella and Other Rarely Investigated Veterinary and Zoonotic Pathogens Darren J. Trott, Sam Abraham, and Ben Adler 23. Antimicrobial Resistance in Chlamydiales, Rickettsia, Coxiella, and Other Intracellular Pathogens Daisy Vanrompay et al. 24. Antimicrobial Drug Resistance in Fish Pathogens Ron A. Miller and Heather Harbottle 25. Antimicrobial Resistance in One-Health Perspective Scott A. McEwen and Peter J. Colignon 26. Licensing and Approval of Antimicrobial Agents for Use in Animals Constanca Pomba et al. 27. Monitoring Antimicrobial Drug Usage in Animals: Methods and Applications Nicole Werner, Scott A. McEwen, and Lothar Kreienbrock 28. The Present and Future Surveillance of Antimicrobial Resistance in Animals: Principles and Practices Shabbir Simjee et al. 29. Source Attribution Models and Risk Assessment Sara M. Pires, Ana SofiaDuarte, and Tine Hald 30. Optimization of Treatment to Minimize Resistance Selection Luca Guardabassi et al. 31. Antimicrobial Stewardship in Veterinary Medicine David H. Lloyd and Stephen W. Page