Bayesian Biostatistics and Diagnostic Medicine

It is interesting to read this book on Bayesian biostatistics and diagnostic medicine. ... this book has several unique features. ... an excellent introductory textbook on Bayesian methods and their application in diagnostic medicine. Non-experienced statisticians may also find that the systematic overview of the classification and purposes of the three phases in clinical trials and the basic Bayesian theory are useful references and would benefit from the program codes, particularly WinBUGS codes. ... -Pharmaceutical Statistics, 2011, 10 ...the inclusion of plenty of real examples plus details of the necessary BUGS code was a very positive attribute. Some of the data sets are available for the reader to analyse and this would further enhance understanding. Overall, it is certainly a useful read or reference book for a practicing statistician with a good baseline theoretical knowledge who would like to expand their interest in this specific field of application. -A. Wade, University College London, Journal of the Royal Statistical Society, Series A, 2010 This book is quite a good one for a statistician that is (or training to be) a statistical consultant to a cancer center department of diagnostic imaging ... . If you are such a person, this book should be in your library. -David Booth, Technometrics, August 2010 Drawing on his collaborative experiences with medical researchers and his long-standing interests in Bayesian methods, the author of this book shows how the Bayesian approach can be used to advantage when medical diagnosis is based on data with uncertainty. ... a general strength of the book is careful discussion of study designs and protocols, which is a bonus relative to many biostatistical books written from a more narrow theory and methods perspective. ... A real strength is the strong integration between models and concepts on the one hand, and real studies on the other hand. The inclusion of WinBUGS code is also a plus. ... this book is highly recommended for anyone whose interests touch on the statistical side of diagnostic medicine. -Biometrics, March 2009

Lyle D. Broemeling, MEDICAL LAKE WA, U.S.A

INTRODUCTION Introduction Statistical Methods in Diagnostic Medicine Preview of Book Datasets for Book Software References DIAGNOSTIC MEDICINE Introduction Imaging Modalities Activities in Diagnostic Medicine Accuracy and Agreement Developmental Trials for Imaging Protocol Review and Clinical Trials The Literature References OTHER DIAGNOSTIC PROCEDURES Introduction Sentinel Lymph Node Biopsy for Melanoma Tumor Depth for Diagnosis of Metastatic Melanoma A Biopsy of Non-Small Cell Lung Cancer Coronary Artery Disease BAYESIAN STATISTICS Introduction Bayes Theorem Prior Information Posterior Information Inference Sample Size Computing Exercises References BAYESIAN METHODS FOR DIAGNOSTIC ACCURACY Introduction Study Design Bayesian Methods for Diagnostic Accuracy: Binary and Ordinal Data Bayesian Methods for Test Accuracy: Quantitative Variables Clustered Data Comparing Accuracy between Modalities Sample Size Determination Exercises References REGRESSION AND TEST ACCURACY Introduction The Audiology Study The ROC Curve and Patient Covariates Exercises References AGREEMENT Introduction Agreement for Discrete Ratings Agreement for a Continuous Response Combining Reader Information Exercises References DIAGNOSTIC IMAGING AND CLINICAL TRIALS Introduction Clinical Trials The Protocol Guidelines for Tumor Response Bayesian Sequential Stopping Rules Software for Clinical Trials Examples Exercises References OTHER TOPICS Introduction Imperfect Diagnostic Test Procedures Test Accuracy and Survival Analysis ROC Curves with a Non-Binary Gold Standard Periodic Screening in Cancer Decision Theory and Diagnostic Accuracy Exercises References