Groundbreaking Discoveries in Molecular Neuroscience
De som köpt den här boken har ofta också köpt The Courage To Be Disliked av Ichiro Kishimi, Fumitake Koga (häftad).
Köp båda 2 för 1242 krThis book provides a very personal and readable introduction to the writings of one of the giants in modern psychiatry and neuroscience. * The American Journal of Psychiatry *
Solomon H. Snyder, M.D., is Distinguished Service Professor of Neuroscience, Pharmacology, and Psychiatry at Johns Hopkins University.
About the Author Foreword Introduction Part I: DISCOVERY AND CHARACTERIZATION OF THE OPIATE RECEPTOR- Radioligand Binding Methodologies: New Inventions, New Directions Chapter 1. Opiate Receptor- Demonstration in Nervous Tissue Chapter 2. Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain Chapter 3. Historical Review- Opioid Receptors Part II: CHARACTERIZATION OF THE ENKEPHALINS- The Discovery of Endogenous Opiates and Their Receptors: A Snyderian Saga of Skill and Judgment Chapter 4. Opiate Receptor in Normal and Drug Altered Brain Function Chapter 5. Morphine-Like Peptides in Mammalian Brain- Isolation, Structure Elucidation, and Interactions With the Opiate Receptor Chapter 6. Opioid Peptide Enkephalin- Immunohistochemical Mapping in Rat Central Nervous System Part III: DOPAMINE RECEPTORS AND INFLUENCES OF NEUROLEPTICS- Dopamine Receptor Binding and Its Therapeutics Chapter 7. Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs Chapter 8. Antischizophrenic Drugs- Chronic Treatment Elevates Dopamine Receptor Binding in Brain Chapter 9. Dopamine Receptors, Neuroleptics, and Schizophrenia Part IV: DRUG EFFECTS EXPLAINED AS ACTIONS ON NEUROTRANSMITTER RECEPTORS- Perspectives on Simplicity and Discovery Chapter 10. Antischizophrenic Drugs and Brain Cholinergic Receptors- Affinity for Muscarinic Sites Predicts Extrapyramidal Effects Chapter 11. Tricyclic Antidepressants- Therapeutic Properties and Affinity for -Noradrenergic Receptor Binding Sites in the Brain Part V: DRUG ACTIONS AND SEROTONIN RECEPTOR SUBTYPES- Clinical Data Stimulation of Basic Research: The Far-Reaching Clinical Significance of Serotonin Receptor Subtype Identification Chapter 12. Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding Chapter 13. Two Distinct Central Serotonin Receptors With Different Physiological Functions Part VI: INOSITOL PHOSPHATES AND ACTIONS OF LITHIUM- Lithium, Second Messengers, and Downstream Effects Chapter 14. Lithium Blocks a Phosphoinositide-Mediated Cholinergic Response in Hippocampal Slices Chapter 15. Solubilization, Purification, and Characterization of an Inositol Trisphosphate Receptor Chapter 16. Second Messenger Systems and Psychoactive Drug Action- Focus on the Phosphoinositide System and Lithium Chapter 17. Purified Inositol 1,4,5-Trisphosphate Receptor Mediates Calcium Flux in Reconstituted Lipid Vesicles Part VII: NITRIC OXIDE AS A NEUROTRANSMITTER- Just Say "Yes": Snyder's Approach to the Difficult Problem of NO Chapter 18. Nitric Oxide Mediates Glutamate-Linked Enhancement of cGMP Levels in the Cerebellum Chapter 19. Cloned and Expressed Nitric Oxide Synthase Structurally Resembles Cytochrome P-450 Reductase Chapter 20. Behavioral Abnormalities in Male Mice Lacking Neuronal Nitric Oxide Synthase Part VIII: D-AMINO ACIDS AS NEUROTRANSMITTERS- Disruptive Science: Incongruent Findings Lead to Novel Insights Into How the Brain Works Chapter 21. D-Aspartate Localizations Imply Neuronal and Neuroendocrine Roles Chapter 22. Serine Racemase- A Glial Enzyme Synthesizing D-Serine to Regulate Glutamate-N-Methyl-D-Aspartate Neurotransmission Chapter 23. Serine Racemase- Activation by Glutamate Neurotransmission via Glutamate Receptor Interacting Protein and Mediation of Neuronal Migration Part IX: NEURAL MESSENGERS OF CELL LIFE AND DEATH- Beyond Neurotransmitters Chapter 24. Cytochrome c Binds to Inositol 1,4,5-Trisphosphate Receptors, Amplifying Calcium-Dependent Apoptosis Chapter 25. Bilirubin Benefits: Cellular Protection by a Biliverdin Reductase Antioxidant Cycle Chapter 26. S-Nitrosylated GAPDH Initiates Apoptotic Cell Death by Nuclear Translocation Following Siah1 Binding Part X: WHAT MAKES FOR CREATIVE DISCOVERY IN SCIENCE?- What Creates Creative Science and Scientists? Chapter 27. The Audacity Principle in Science Index