Adrenergic Receptors (e-bok)
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Engelska
Antal sidor
450
Förlag
Humana Press
ISBN
9781592599318

Adrenergic Receptors E-bok

In the 21st Century

av Dianne M Perez
E-bok (PDF, LCP),  Engelska
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An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
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Innehållsförteckning

Part I: Historical Perspectives; Adrenergic Receptors: Historical Perspectives from the 20th Century; David B. Bylund; Part II: Structure-Function; Ligand Binding, Activation, and Agonist Trafficking; Angela Finch, Valerie Sarramegna, and Robert M. Graham; New Signal Transduction Paradigms; Kenneth P. Minneman; Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors; Michael T. Piascik, Mary Lois Garcia-Cazarin, and Steven R. Post; Adrenergic Receptors in Clinical Medicine; Martin C. Michel and Paul A. Insel; Part III: Imaging Adrenergic Receptors and Their Function; The Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors; John C. McGrath and Craig J. Daly; Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors; Dianne M. Perez; Part IV: Genetically-Altered Mouse Models; The [alpha]1-Adrenergic Receptors: Lessons from Knockouts; Paul C. Simpson; The [alpha]2-Adrenergic Receptors: Lessons from Knockouts; Christopher M. Tan and Lee E. Limbird; The b-Adrenergic Receptors: Lessons from Knockouts; Yang Xiang and Brian Kobilka; Lessons from Overexpressed Mouse Models; Cinzia Perrino, Liza Barki-Harrington, and Howard A. Rockman; Adrenergic Receptor Signaling Components in Gene Therapy; Andrea D. Eckhart and Walter J. Koch; Part V: Pharmacogenomics; Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms; Stephen B. Liggett; Microarray Analysis of Novel Adrenergic Receptor Function; Boyd Rorabaugh, June Yun, and Dianne M. Perez

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