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- DEStech Publications, Inc
- 241 x 158 x 25 mm
- 703 g
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Nanotechnologies for Solubilization and Delivery in Foods, Cosmetics and Pharmaceuticals1839
Beginning with the basics of surfactant chemistry and micellization, this book presents a range of nanotechnology strategies for controlling colloidal and polymeric structures for the solubilization and targeted delivery of food nutrients and pharmaceuticals. The book demonstrates how vehicles for delivering bioactive ingredients through a variety of oral, transdermal, buccal and mucosal routes, can be synthesized by nanolevel manipulation of colloidal systems, proteins, peptides, liquid crystalline phases, organogels and dendrimers. Special attention is given to the modification of mesophases in micellar and liquid crystal systems, which are shown to be productive templates and chemical nanoreactors for uniquely structured nanocarriers. The volume connects micro - and nanolevel modification of emulsion-based and biopolymeric systems, as well as the formation of new nanoparticles, to key properties of absorption, bioavailability and therapeutic effectiveness for dozens of well-known and experimental drugs, food nutrients and antimicrobials. Throughout, a stress is placed on chemical strategies for enhancing the efficiency of drug and nutrient carriers.The information presented in this book is applicable to the design of micro - and nanolevel delivery systems with improved targeting, more efficient controlled release, and superior in vivo penetration into dermal and cellular structures. This book includes: new strategies for designing drug and nutrient delivery systems; micellar and reverse micellar techniques for synthesizing nanocarriers and particles; novel vehicles from lipids, biopolymers, gels, dendrimers and more; methods for better solubility, penetration, absorption and bioavailability of bioactives.
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Preface; Chapter 1. Surfactants in Solution - Basic Concepts; Shmaryahu Ezrahi, Abraham Aserin, Rivka Efrat,; Dima Libster, Eran Tuval, and Nissim Garti; Introduction; Interface; Interfacial (surface) Energy; Surface Tension; Surfactants; Micelles and Micellization; Liquid Crystals; Intermediate Phases; Sponge (L3) Phases; Microemulsions; Summary; References; Chapter 2. Micelle Formation: Thermodynamic Aspects and Characterization; Massimo Bonini and Pierandrea Lo Nostro; Introduction; Thermodynamic Aspects; Characterization; Conclusions and Outlook; References; Chapter 3. Microemulsions - Characterization and Selected Applications; Shmaryahu Ezrahi, Dima Libster, Abraham Aserin,; Rivka Efrat, Eran Tuval, and Nissim Garti; Introduction; The Definition of Microemulsion; Microemulsions vs. Emulsions; Microemulsions vs. Nanoemulsions; The Mechanism of Microemulsions Stability; Microstructures of Microemulsions; Characterization of Microemulsions; Phase Behavior; Applications; Summary; References; Chapter 4. Development of Colloidal Delivery Systems for Food and Pharmaceutical Applications Based on Proteins and Polysaccharides; Owen Griffith Jones and D. Julian McClements; Introduction; Biopolymer Materials; Interactions Responsible for Assembly of Biopolymer Aggregates; Assembly Principles; Processing Methods; Cross-linking Methods; Conclusion; References; Chapter 5. Protein- and Lipid-Based Nano- and Micro-Capsules, as Food Micronutrient Carriers; Perla Relkin and Marc Anton; Introduction; Protein-Stabilized Particles as Food Nutrient Carriers; Nano- or Fine-Lipid Droplets as Food Matrix Carriers; LDL - a Natural Nanocapsule to Vectorise Micronutrients; Conclusion; References; Chapter 6. Topical Delivery of Pharmaceuticals using Liquid Crystalline Structures; Dima Libster, Abraham Aserin, and Nissim Garti; Liquid Crystals; LLC as Drug Delivery Vehicles; Hexagonal and Cubic Mesophases and Their Dispersions; as Carriers of Hydrophilic Drugs; Delivery of Lipophilic Drugs from LLC Systems; Conclusion; References; Chapter 7. Recent Advances in the Characterization of Lipid-Based Nanocarriers; Anan Yaghmur and Michael Rappolt; Introduction; Self-Assembly in Soft Lipidic Formulations; Potential Applications as Nanocarriers in Food and Pharmaceutical Industries; Recent Advances in the Characterization of Soft Self-Assembled Systems; Future Challenges and Perspectives; References; Chapter 8. Interfacial Reactivity at Liquid Crystal Interfaces; Idit Amar-Yuli, Abraham Aserin, and Nissim Garti; Introduction; Nanoparticles Synthesis - Liquid Crystalline Phases Perform as Templates; Conclusions; References; Chapter 9. Structured Organogels Based on Vegetable Oils and Surfactants - Structures, Characteristics and Applications; Edmund Co and Alejandro G. Marangoni; The Gel State; Phytosterol Vegetable Oil Organogels; Phospholipid Microemulsion Organogels; Wax-Based Organogels; 2-Hydroxystearic Acid Vegetable Oil Organogels; References; Chapter 10. Characterization and Therapeutic Applications of Immunonanoparticles as Targeted Drug Delivery Systems: A Focus on Cancer Therapy; Nir Debotton and Simon Benita; Introduction; Nanoparticles; NPs as Drug-Delivery Systems for Cancer Therapy; Targeting of NPs; Monoclonal Antibodies; Tumor Cell Antigen Overexpression; Approaches for ImmunoNP Preparation; Therapeutic Applications of ImmunoNP; Conclusions; References; Chapter 11. Embedding Antibacterial Inorganic Nanoparticles and Proteinaceous Microspheres in Textiles by a Sonochemical Method; N. Perkas, A. Gedanken, I. Perelshtein, and U. Angel; A Sonochemical Method for the Synthesis of Nanostructured Materials and their Adherence to Solid Substrates; Antibacterial Finishing of Textiles with Nanoparticles; Embedding Nanosilver into Different Kinds of Textiles by the Sonochemical Technique; Ultrasound Assisted Deposition of Metal Nanooxides on Textiles and Their Antibacterial Properties; Sonochemical Synthesis of Proteinaceous Microspheres and their Depo