Antimalarial Chemotherapy

"With contributions from 41 different authors, this book provides a welcome collection of short reviews covering numerous topics in antimalarial chemotherapy. ...this book will offer a useful review for those who study malaria and, more importantly, an entry point into antimalarial chemotherapy for those new in the field." - Journal of Medicinal Chemistry "...the publication of a new on antimalarial chemotheraphy is very topcial and timely. Philip Rosenthal has put together a very comprehensive book on the current status of research in this important field of medicianl chemistry....The part on established antimalarial drugs covers all drugs currently in clinical application and trials....Special emphasis is put in many articles on aspects of toxicity, therapy, problems, and future developments....the editor has managed to compile the contributions in such a way that a comprehensive picture of the current status emerges and the book feels more like a single-author publication than an edited work....The book is a must for chemists, biologists, and health professionals involved in malaria research." - ChemBioChem "...thought provoking with its new leads to drug discovery...an essential addition to the libraries and an essential reading book for malariologists." -The National Journal of India

I Introduction.- 1 The Need for New Approaches to Antimalarial Chemotherapy.- 2 The History of Antimalarial Drugs.- 3 Transport and Trafficking in Plasmodium-Infected Red Cells.- 4 The Plasmodium Food Vacuole.- 5 Clinical and Public Health Implications of Antimalarial Drug Resistance.- II Established Antimalarial Drugs and Compounds Under Clinical Development.- 6 Chloroquine and Other Quinoline Antimalarials.- 7 8-Aminoquinolines.- 8 Mechanisms of Quinoline Resistance.- 9 Folate Antagonists and Mechanisms of Resistance.- 10 Artemisinin and Its Derivatives.- 11 AtovaquoneProguanil Combination.- 12 The Antimalarial Drug Portfolio and Research Pipeline.- III New Compounds, New Approaches, and New Targets.- 13 Novel Quinoline Antimalarials.- 14 New Antimalarial Trioxanes and Endoperoxides.- 15 Antibiotics and the Plasmodial Plastid Organelle.- 16 Fresh Paradigms for Curative Antimetabolites.- 17 Iron Chelators.- 18 Protease Inhibitors.- 19 Inhibitors of Phospholipid Metabolism.- 20 Development of New Malaria Chemotherapy by Utilization of Parasite-Induced Transport.