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Köp båda 2 för 2112 krEpidemiology of Chronic Disease: Global Perspectives is the most current and authoritative resource on the epidemiology, etiology, pathogenesis, risk factors and preventive factors of over 50 major chronic diseases and conditions. This comprehensi...
In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The autho...
"...a must, not only for oncologists but also for every family doctor, who is often the first to see a patient with a cancerous or precancerous or precancerous condition." -Lancet Oncology "This comprehensive and up-to-date monograph demonstrates how COX-2 inhibitors and other NSaids reduce the risk of most cancers and provides cancer investigators by a clear and authoritative guide leading to the development of novel angst with significant antineoplastic properties." -Neoplasma
I. Historical Perspectives.- l Dietary Fatty Acids, COX-2 Blockade, and Carcinogenesis.- 2 Historical Aspects of COX-2: Cloning and Characterization of the cDNA, Protein and Gene.- II. Epidemiology of NSAIDS and Cancer.- 3 Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancer.- 4 Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast Cancer.- III. Animal Models of Carcinogenesis.- 5 Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Prevention.- 6 Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in Animals.- 7 The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung Cancer.- 8 Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal Tumorigenesis.- 9 Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs.- IV. Molecular Biology of CXO.- 10 Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis.- 11 Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2.- 12 Cyclooxygenase-2 and Cancer.- 13 Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cells.- 14 Association of COX-2 and PPARs in Carcinogenesis and Chemoprevention.- 15 Carcinogenesis Involving Cyclooxygenase and Lipoxygenase.- V. Clinical Applications.- 16 The Development of Drugs that Target Cyclooxygenase-2.- 17 Chemoprevention of Cancer by NSAIDs and Selective COX-2 Blockade.- 18 Potential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor Radioresponse.- 19 Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapy.- 20 Cyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of Impact.