- Häftad (Paperback / softback)
- Antal sidor
- Softcover reprint of hardcover 1st ed. 2006
- Humana Press Inc.
- Perez, Dianne M. (ed.)
- XII, 404 p.
- 229 x 152 x 22 mm
- Antal komponenter
- 1 Paperback / softback
- 563 g
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Dianne M BroussardInbunden
The Adrenergic Receptors
In the 21st Century2039Skickas inom 10-15 vardagar.
Fri frakt inom Sverige för privatpersoner.An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
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Dianne M Perez
An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics rang...
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From the reviews: "...useful to anyone interested in adrenoceptor physiology/pharmacology or in the design of drugs interacting with the receptor or its signal transduction pathway." -Journal of Medicinal Chemistry "Dianne Perez has assembled a number of important contributors to the research area and grouped the 15 chapters into six parts. ... many MDs, biologists, and pharmacologists will find the book ... appealing, as the receptor class is involved in numerous cardiovascular and pulmonary diseases." (Boris Schmidt, ChemMedChem, Issue 1, 2006)
Part I: Historical Perspectives Adrenergic Receptors: Historical Perspectives From the 20th Century David B. Bylund Part II: Structure-Function Ligand Binding, Activation, and Agonist Trafficking Angela M. Finch, Valerie Sarramegna, and Robert M. Graham New Signal Transduction Paradigms Kenneth P. Minneman Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors Michael T. Piascik, Mary Lolis Garcia-Cazarin, and Steven R. Post Adrenergic Receptors in Clinical Medicine Martin C. Michel and Paul A. Insel Part III: Imaging Adrenergic Receptors and Their Function Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors John C. McGrath and Craig J. Daly Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors Dianne M. Perez Part IV: Genetically Altered Mouse Models The a1-Adrenergic Receptors: Lessons From Knockout Paul C. Simpson The a2-Adrenergic Receptors: Lessons From Knockouts Christopher M. Tan and Lee E. Limbird The b-Adrenergic Receptors: Lessons From Knockouts Yang Xiang and Brian Kobilka Lessons From Overexpressed Mouse Models Cinzia Perrino, Liza Barki-Harrington, and Howard A. Rockman Adrenergic Receptor Signaling Components in Gene Therapy Andrea D. Eckhart and Walter J. Koch Part V: Pharmacogenomics Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms Stephen B. Liggett Microarray Analysis of Novel Adrenergic Receptor Functions Boyd Rorabaugh, June Yun, and Dianne M. Perez Part VI: Summary and Future Endeavors Summary and Future Endeavors Dianne M. Perez Index