Excitotoxicity (häftad)
Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
86
Utgivningsdatum
2013-12-01
Förlag
Nova Science Publishers Inc
Illustrationer
illustrations (black and white)
Dimensioner
228 x 152 x 6 mm
Vikt
181 g
ISBN
9781629484853
Excitotoxicity (häftad)

Excitotoxicity

Fundamental Concepts, Pathophysiology & Treatment Strategies

Häftad Engelska, 2013-12-01
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Excitotoxicity is the pathological process in which neurons are damaged and killed by over-stimulation of the excitatory neurotransmitter glutamate receptors. Excitotoxicity may be involved in spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity) and in neurodegenerative diseases of the central nervous system (CNS) such as multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, alcoholism or alcohol withdrawal and especially benzodiazepine withdrawal, and also Huntington's disease. In this book, the authors discuss the fundamental concepts, pathophysiology and treatment strategies of excitotoxicity. Topics include the involvement of glutamate excitotoxicity in Parkinson's disease; the relevance of the excitotoxic process to schizophrenia; the role of glial cells during the regenerative process and possible strategies of treatment to avoid neuronal damage; and an overview of the current concepts related to the intermittent-hypoxia-induced excitotoxicity in obstructive sleep apnea (OSA) disease.
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Innehållsförteckning

Preface; Dissecting Involvement of Glutamate Excitotoxicity in Parkinsons Disease; Excitotoxicity & Schizophrenia; Glial Cells on Microenvironment of Motoneurons: An Important Insight for Understanding the Mechanisms That Limit Neuronal Damage; Excitotoxicity in Obstructive Sleep Apnea Disease; Index.