Chromosomal Translocations and Genome Rearrangements in Cancer (inbunden)
Fler böcker inom
Format
Inbunden (Hardback)
Språk
Engelska
Antal sidor
490
Utgivningsdatum
2015-12-18
Upplaga
1st ed. 2015
Förlag
Springer International Publishing AG
Medarbetare
Rowley, Janet (ed.), Le Beau, Michelle M. (ed.), Rabbitts, Terence H. (ed.)
Illustratör/Fotograf
6 schwarz-weiße und 12 farbige Tabellen 3 schwarz-weiße und 70 farbige Abbildungen Bibliographie
Illustrationer
12 Tables, color; 6 Tables, black and white; 69 Illustrations, color; 3 Illustrations, black and whi
Dimensioner
241 x 159 x 32 mm
Vikt
1099 g
Antal komponenter
1
Komponenter
1 Hardback
ISBN
9783319199825

Chromosomal Translocations and Genome Rearrangements in Cancer

av Janet D Rowley, Michelle M Le Beau, Terence H Rabbitts
Inbunden,  Engelska, 2015-12-18
3093
Köp
Spara som favorit
  • Skickas från oss inom 3-6 vardagar.
  • Fri frakt över 249 kr för privatkunder i Sverige.
Finns även som
Visa alla 2 format & utgåvor
This volume collates world experts insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics. Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours. Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.
Visa hela texten

Passar bra ihop

  1. Chromosomal Translocations and Genome Rearrangements in Cancer
  2. +
  3. Co-Intelligence

De som köpt den här boken har ofta också köpt Co-Intelligence av Ethan Mollick (häftad).

Köp båda 2 för 3283 kr

Kundrecensioner

Har du läst boken? Sätt ditt betyg »

Fler böcker av författarna

  • Myelodysplastic Syndromes

    Myelodysplastic Syndromes

    H Joachim Deeg, David T Bowen, Steven D Gore, Torsten Haferlach, Michelle M Le Beau

    The diagnosis of myelodysplastic syndromes (MDS), a heterogeneous group of clonal hematopoietic disorders, is being made with increasing frequency over the past decade owing to increased recognition, improved understanding, and an aging population...

    1749
    Köp
    Skickas inom vardagar.

Recensioner i media

An updated review of chromosomal aberrations related to cancer. For geneticists and oncologists. (Pediatric Endocrinology Reviews, Vol. 13 (4), June, 2016)

Innehållsförteckning

Part I Introduction Chapter 1 - A short history of chromosome rearrangements and gene fusions in cancer Felix Mitelman Part II General Chapter 2 Molecular genetics methods in discovery of chromosome structure Donna Albertson Chapter 3 Mechanism of recurrent chromosomal translocations Fred Alt, Richard Frock, Jiazhi Hu Chapter 4 Chromosome translocations, cancer initiation and clonal evolution Mel Greaves, Anthony M Ford Chapter 5 Chromosomal fragile sites and cancer Michelle LeBeau, Yanwen Jiang, Isabelle Lucas Chapter 6 Copy number changes in carcinomas: applications Pamela Rabbitts, Henry Wood Part III LEUKAEMIA/LYMPHOMA Chapter 7 Chronic myeloid leukaemia Junia Melo, Debora A Casolari Chapter 8 Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis P. Leif Bergsagel, W.Michael Kuehl Chapter 9 Genetic alterations in B cell lymphoma Riccardo Dalla Favera, Marco Fangazio, Laura Pasqualucci Chapter 10 Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia Tom Look, Marc Mansour Chapter 11 Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies Chi Wai Eric So, Bernd Zeisig Chapter 12 Acute promyelocytic leukaemia: from a specific translocation to cure by targeted therapies Hugues de The, Kim Rice Chapter 13 Chromosome Abnormalities in AML and their clinical importance Clara Bloomfield, Krzysztof Mrozek PART IV SARCOMAS Chapter 14 Fusion Oncogenes of Sarcomas Pierre Aman Chapter 15 Translocations in Ewing Sarcoma Stephen L Lessnick, Jason M Tanner PART V EPITHELIAL TUMOURS Chapter16 RET and thyroid carcinomas Giancarlo Vecchio, Maria Domenica Castellone Chapter 17 Gene fusions in prostate cancer Scott Tomlins, A.S.McDaniel Chapter 18 Chromosomal Translocations in Lung Cancer Hiroyuki Mano Chapter 19 Colon & Ovarian translocations Paul T. Spellman PART VI OTHER ASPECTS Chapter 20 Pre-clinical modeling of chromosomal translocations and inversions Terry Rabbitts, Katia Ruggero Chapter 21 Protein complex hierarchy & translocation gene products Jacqueline Matthews Chapter 22 Aberrant transcriptional programming in blood cancers Constanze Bonifer, Peter N. Cockerill, Anetta Ptasinska Index

Du kanske gillar