Myeloid-Derived Suppressor Cells and Cancer (häftad)
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Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
102
Utgivningsdatum
2016-03-23
Upplaga
1st ed. 2016
Förlag
Springer International Publishing AG
Medarbetare
Talmadge, James E. / Breckpot, Karine
Illustratör/Fotograf
Bibliographie
Illustrationer
8 Illustrations, color; IX, 102 p. 8 illus. in color.
Dimensioner
234 x 156 x 6 mm
Vikt
173 g
Antal komponenter
1
Komponenter
1 Paperback / softback
ISBN
9783319268194

Myeloid-Derived Suppressor Cells and Cancer

av David Escors, James E Talmadge, Karine Breckpot, Jo A Van Ginderachter, Grazyna Kochan
Häftad,  Engelska, 2016-03-23
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The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.
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Innehållsförteckning

Controversies in Neoplastic Myeloplasia.- Differentiation of Murine Myeloid-derived Suppressor Cells.- Human MDSCs.- Ex Vivo MDSC Differentiation Models.- Immunoregulatory myeloid cells in the tumor microenvironment.- Signal Transducer and Activation of Transcription 3: A Master Regulator of Myeloid-derived Suppressor Cells.- Future Perspectives.

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