Formulating Poorly Water Soluble Drugs (e-bok)
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Språk
Engelska
Utgivningsdatum
2016-12-16
Förlag
Springer International Publishing
ISBN
9783319426099

Formulating Poorly Water Soluble Drugs E-bok

av Robert O Williams Iii, Alan B Watts, Dave A Miller
E-bok (PDF, LCP),  Engelska, 2016-12-16
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The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist's approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound's physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop
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