Ageing: Lessons from C. elegans (häftad)
Häftad (Paperback / softback)
Antal sidor
Softcover reprint of the original 1st ed. 2017
Springer International Publishing AG
Gill, Matthew S.
32 Illustrations, color; 8 Illustrations, black and white; VI, 439 p. 40 illus., 32 illus. in color.
Antal komponenter
1 Paperback / softback
Ageing: Lessons from C. elegans (häftad)

Ageing: Lessons from C. elegans

Häftad Engelska, 2018-07-11
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This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans. With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.
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Chapter 1 Introduction - Anders Olsen and Matthew S. Gill Chapter 2 Effects of aging on the basic biology and anatomy of C. elegans - Laura A. Herndon, Catherine A. Wolkow, Monica Driscoll and David H. Hall Chapter 3 Dauer Formation and Ageing - Pedro Reis Rodrigues, Kailiang Jia and Matthew S. Gill Chapter 4 Longevity regulation by insulin/IGF-1 signaling - Seon Woo A. An, Murat Artan, Sangsoon Park, Ozlem Altintas, and Seung-Jae V. Lee Chapter 5 Mitochondrial longevity pathways - Alfonso Schiavi and Natascia Ventura Chapter 6 Influences of Germline Cells on Organismal Lifespan and Healthspan - Francis R.G. Amrit and Arjumand Ghazi Chapter 7 Reproductive Aging - Cheng Shi & Coleen T. Murphy Chapter 8 Nervous System Ageing - Claire Benard and Maria Doitsidou Chapter 9 Stress Response Pathways - Dana L. Miller*, Joseph Horsman, and Frazer Heinis Chapter 10 Oxidative Stress - Bart P. Braeckman, Patricia Back, Filip Matthijssens Chapter 11 Genome stability and ageing - Aditi U. Gurkar, Matthew S. Gill and Laura J. Niedernhofer Chapter 12 Protein homeostasis and ageing in C. elegans - Silvestre Alavez Chapter 13 Translational control of longevity - Jarod Rollins and Aric Rogers Chapter 14 Lipid Metabolism, Lipid Signaling and Longevity - Jonathon Duffy, Ayse Sena Mutlu, Meng C. Wang Chapter 15 Autophagy and ageing - Malene Hansen Chapter 16 Dietary restriction in C. elegans - Yue Zhang and William B. Mair Chapter 17 Integration of metabolic signals - Dana A. Lynn and Sean P. Curran Chapter 18 Microbiota, Probiotic Bacteria and Ageing - Katrine V. Christensen, Maria G. Morch, Tine H. Morthorst, Simon Lykkemark and Anders Olsen Chapter 19 The Future of Worm Ageing - Gordon J. Lithgow Index