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Chromaffin cells and Granins: History and Perspectives.- The extended granin family: structure, function, and biomedical implications.- CgA and CgB in granule secretion.- Proteolytic processing of CgA and CgB/Antimicrobial properties of Chromogranins.- Chromogranins and inositol 1,4,5-trisphosphate-dependent Ca2+-signaling.- CgA in angiogenesis and tumor biology.- Full lenght CgA: a multifaceted protein in cardiovascular health and disease.- Physio-pharmacological aspects of three Chromogranin A-derived peptides: Vasostatin, Catestatin, and Serpinin.- Comparative aspects of CgA-derived peptides in cardiac homeostasis.- Molecular and cellular mechanisms of action of CgA-derived peptides in cardiomyocytes and endothelial cells.- CgA-derived peptides in pre- and post-conditioning cardioprotection.- Catestatin in physiopathology.- Serpinin: from biosynthesis to cell biology and physiopathology.- Pancreastatin and metabolism.- Chromogranins and the quantum release of catecholamines.