Iridium Complexes in Organic Synthesis

?This book provides good coverage of an increasingly important area and will be well worth reading by anyone interested in metal-catalyzed organic synthesis.? (The Journal of the American Chemical Society, July 2009) ?Both academic and industrial practitioners of transition-metal catalysis and organometallic chemistry will find this volume to be a very useful addition to their bookshelves.? ( Angewandte Chemie International Edition , June 2009)

Luis A. Oro is the head of the Homogeneous Catalysis Institute and professor of Inorganic Chemistry in the University of Zaragoza. His main research interests are in organometallic chemistry of platinum group metals where he has coauthored about 500 scientific contributions, and edited several books. He is member of the Interantional Advisory Board of Angewandte Chemie, and other international journals. He has received several scientific awards, including the Humboldt award, King Jaime prize, Solvay prize and Sacconi Medal. He is Doctor Honoris Causae by Rennes University. He is also member of the Deutsche Akademie der Naturforscher Leopoldina, the Academia Europaea, and foreign member of the Acadmie des Sciences. Carmen Claver is Professor of Inorganic Chemistry at the University Rovira I Virgili in Tarragona (Spain). She has co-authored about 200 scientific contributions in the field of enantioselective synthesis. She has also participated in the edition and publication of several books. She has received several scientific awards, being recognised in 2003 as distinguished research for the Catalan Government.

APPLICATION OF IRIDIUM CATALYSTS IN THE FINE CHEMICALS INDUSTRY Introduction Industrial Requirements for Applying Catalysts Enantioselective Hydrogenation of C=N Bonds Enantioselective Hydrogenation of C=C Bonds Miscellaneous Catalytic Applications with Industrial Potential DIHYDRIDO IRIDIUM TRIISOPROPYLPHOSPHINE COMPLEXES: FROM ORGANOMETALLIC CHEMISTRY TO CATALYSIS Introduction [Ir(COD)(NCMe)(PR3)]BF4 (PR=PiPr3, PMe3) and Related Complexes as Catalyst Precursors: Is 1,5-Cyclo-Octadiene an Innocent and Removable Ligand? The Dihydrido Iridium Triisopropylphosphine Complex [IrH2(NCMe)3(PiPr3)]BF4 as Alkene Hydrogenation Catalysts The Dihydrido Iridium Triisoprpylphosphine Complex [IrH2(NCMe)3(PiPr3)]BF4 as Alkyne Hydrogenation Catalysts Dihydrido Arene Iridium Triisopropylphosphine Complexes Dihydrido Iridium Triisopropylphosphine Complexes as Imine Hydrogenation Catalysts IRIDIUM N-HETEROCYCLIC CARBENE COMPLEXES AND THEIR APPLICATON AS HOMOGENEOUS CATALYSTS Introduction Types or Ir-NHC and Reactivity Catalysis with Ir-NHCs IRIDIUM-CATALYZED C=O HYDROGENATION Introduction Homogeneous C=O Hydrogenations Heterogeneous, Supported and Biocatalytic Hydrogenations CATALYTIC ACTIVITY OF Cp* IRIDIUM COMPLEXES IN HYDROGEN TRANSFER REACTONS Introduction Hydrogen Transfer Oxidation of Alcohols (Oppenauer-Type Oxidation) Transfer Hydrogenation of Unsaturated Compounds Asymmetric Synthesis Based on Hydrogen Transfer Hydrogen Transfer Reactions in Aqueous Media Carbon-Nitrogen Bond Formation Based on Hydrogen Transfer Carbon-Carbon Bond Formation Based on Hydrogen Transfer Carbon-Oxygen Bond Formation Based on Hydrogen Transfer Dehydrogenative Oxidation of Alcohols IRIDIUM-CATALYZED HYDROAMINATION Introduction Iridium-Catalyzed Olefin Hydroamination (OHA) Iridium-Catalyzed Alkyne Hydroamination (ASA) Proposed Mechanisms Complexes and Reactions of Ir Relevant to Hydroamination IRIDIUM-CATALYZED BORON-ADDITION Introduction Iridium-Boryl Complexes Hydroboration Diboration Borylation IRIDIUM-CATALYZED METHANOL CARBONYLATION Introduction Rhodium-Based Processes Iridium Reactivity in the Methanol Carbonylation Reaction The Iridium-Based Cativa Process The Iridium-Platinum-Based Process The Iridium-Cocatalyst Mechanism, and Conclusion Acknowledgments IRIDIUM-CATALYZED ASYMMETRIC ALLYLIC SUBSTITUTIONS Introduction Ir-Catalyzed Allylic Substitutions: Fundamentals C-Nucleophiles N-Nucleophiles O-Nucleophiles Synthesis of Biologically Active Compounds via Allylic Substitution IRIDIUM-CATALYZED COUPLING REACTIONS Introduction Iridium-Catalyzed Dimerization and Cyclotrimerization of Alkynes Iridium-Catalyzed, Three-Component Coupling Reactions of Aldehydes, Amines and Alkynes Head-to-Tail Dimerization of Acrylates A Novel Synthesis of Vinyl Ethers via an Unusual Exchange Reaction Iridium-Catalyzed Allylic Substitution Alkylation of Ketones with Alcohols N-Alkylation of Amines Oxidative Dimerization of Primary Alcohols to esters Iridium-Catalyzed Addition of Water and Alcohols to Terminal Alkynes Iridium-Catalyzed Direct Arylation of Aromatic C-H Bonds Iridium-Catalyzed Anti-Markovnikov Olefin Arylation Iridium-Catalyzed Silylation and Borylation of Aromatic C-H Bonds Miscellaneous Reactions Catalyzed by Iridium Complexes IRIDIUM-CATALYZED CYCLOADDITIONS Introduction [2+2+2] Cycloaddition Enantioselective [2+2+2] Cycloaddition [2+2+1] Cycloaddition [4+2] and [5+1] Cycloaddition Cycloisomerization Ir(III)-Catalyzed Cyclizations Miscellaneous Cycloadditions PINCER-TYPE IRIDIUM COMPLEXES FOR ORGANIC TRANSFORMATIONS Introduction Iridium PCP-Catalyzed Activation of C(sp3)-H Bonds in Unfunctionalized Alkanes Arene C(sp2)-H and Alyne C(sp1)-H Bond Activation C-E Bond Activation Ammonia Borane Dehydrogenation IRIDIUM-MEDIATED ALKANE DEHYDROGENATION Introduction Alkane C-H Activation with Ir Derivatives Alkane Dehydrogenation with Ir Complexes Alkane Dehydrogenation Catalyzed