Diabetes, Insulin and Alzheimer's Disease (inbunden)
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Format
Inbunden (Hardback)
Språk
Engelska
Antal sidor
218
Utgivningsdatum
2010-03-05
Förlag
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Medarbetare
Christen, Yves
Illustratör/Fotograf
4 farbige Fotos 9 schwarz-weiße und 21 farbige Abbildungen 9 schwarz-weiße und 17 farbige Zeichnun
Illustrationer
21 Illustrations, color; 9 Illustrations, black and white; XIV, 218 p. 30 illus., 21 illus. in color
Dimensioner
239 x 160 x 15 mm
Vikt
545 g
Antal komponenter
1
Komponenter
1 Hardback
ISBN
9783642042997

Diabetes, Insulin and Alzheimer's Disease

av Suzanne Craft
Inbunden,  Engelska, 2010-03-05
2233
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The central nervous system controls vital functions by ef?ciently coordinating peripheral and central cascades of signals and networks in an orchestrated manner. Historically, the brain was considered to be insulin independent. These earlier views have been challenged by ?ndings demonstrating that insulin exerts multiple actions in the brain, regulating vital biological processes such as life span, neuronal survival, cognition, reproduction, feeding behavior, energy balance, and glucose and fat metabolism, and that inef?cient central action of insulin contributes to the development of severe pathologies (Banks et al. 2000; Gerozissis 2003, 2004, 2008; Lustman and Clouse 2005; Okamoto et al. 2001; Park 2002; Perrin et al. 2004; Pocai et al. 2005; Reger et al. 2008; Schwartz and Porte, 2005; Schubert et al. 2004; van der Heide et al. 2005; Woods et al. 1979; Wrighten et al. 2008). Insulin and speci?c insulin receptors are widely distributed in the networks of the central nervous system related mainly to feeding or cognition (Baskin et al. 1983; Bruning et al. 2000; Gerozissis 2003, 2008; Havrankova et al. 1978a, b; Schechter et al. 1996; Schulingkamp et al. 2000; Schwartz et al. 1992; Zhao et al. 2004). Insulin receptors located in the synapses of neurons and in astrocytes are present in high concentrations in the cerebral cortex, olfactory bulb, hippocampus, amygdala, cerebellum and hypothalamus (Abbott et al., 1999; Havrankova et al.
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Innehållsförteckning

Insulin Action in the Brain and the Pathogenesis of Alzheimers Disease.- The Brain-insulin Connection, Metabolic Diseases and Related Pathologies.- Insulin-Mediated Neuroplasticity in the Central Nervous System.- Stress Hormones and Neuroplasticity in the Diabetic Brain.- Diabetes and the Brain An Epidemiologic Perspective.- Cognition in Type 2 Diabetes: Brain Imaging Correlates and Vascular and Metabolic Risk Factors.- The Relationship Between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late-onset Alzheimers Disease: An Epidemiological Perspective.- The Role of Insulin Dysregulation in Aging and Alzheimers Disease.- Is Alzheimers a Disorder of Ageing and Why Dont Mice get it? The Centrality of Insulin Signalling to Alzheimers Disease Pathology.- PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD.- Diet, Abeta Oligomers and Defective Insulin and Neurotrophic Factor Signaling in Alzheimers Disease.- Serum IGF-I, Life Style, and Risk of Alzheimers disease.

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