Pharmacokinetic / Pharmacodynamic (Pk/Pd) Modelling (häftad)
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Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
92
Utgivningsdatum
2012-05-29
Förlag
LAP Lambert Academic Publishing
Illustrationer
black & white illustrations
Antal komponenter
1
Komponenter
Paperback
ISBN
9783659129186
Pharmacokinetic / Pharmacodynamic (Pk/Pd) Modelling (häftad)

Pharmacokinetic / Pharmacodynamic (Pk/Pd) Modelling

Pharmacokinetic / Pharmacodynamic (PK/PD) Modelling- with a pre-clinical application

Häftad Engelska, 2012-05-29
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Pharmacokinetic-Pharmacodynamic (PK/PD) modeling is scientific mathematical tool which integrates relationship PK model to that of PD model and a statistical model (particularly, the intra- and inter-individual variability of PK and/or PD origin). PK-PD approach is used from initial preclinical stage to last clinical phases for exploring the concentration-effect relationships executed using various approaches, such as steady state concentrations versus non-steady state concentrations models and parametric versus nonparametric models. Basing on the concentration-response invariant data basic models such as fixed-effect, linear, log-linear, Emax and sigmaoid Emax models are used. But in case of time-concentration and time-response variant conditions effect compartment, acute tolerance, sensitization and physiological indirect response models have been used. PK/PD modeling can be used as an applied science tool to provide answers on efficacy and safety of new drugs faster and at a lower cost. Still limits of PK/PD approaches include the development of appropriate models, the validity of surrogate endpoints, and the acceptance of these models in a regulatory environment.
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