Development of Sustained Release Tablets of Eplerenone (häftad)
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Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
68
Utgivningsdatum
2012-08-23
Förlag
LAP Lambert Academic Publishing
Medarbetare
Katakam, Vinay Kumar / Yamsani, Madhusudan Rao
Illustrationer
black & white illustrations
Dimensioner
229 x 152 x 4 mm
Antal komponenter
1
Komponenter
Paperback
ISBN
9783659222887
Development of Sustained Release Tablets of Eplerenone (häftad)

Development of Sustained Release Tablets of Eplerenone

Effect of Cellulose and Natural Polymers

Häftad Engelska, 2012-08-23
549
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The objective of this work was to develop of a suitable SR tablet formulation of Eplerenone and to study the effect of polymers such as HPMC K4M, HPMC K15M, NaCMC, Guar gum, Xanthan gum and Karaya gum on drug release. Profile and to get an optimized formulation. Eplerenone binds to the mineralo corticoidreceptorand blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). It has a half life of 4 hrs. When dose is missing it may cause nocturnal attack, so attention was made to develop the Sustained release tablets of Eplerenone. The purpose of controlled release systems is to maintain drug concentration in the blood or in target tissues at a desired value as long as possible. In other words, they are able to exert a control on the drug release rate and duration. In the market only IR tablets of Eplerenone were available which are costly. So there is a need to formulate SRMT of Eplerenone to reduce the cost and increase the patient compliance.
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