NB-UVB Therapy vs Methotrexate on IL17and IL23 in psoriasis (häftad)
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Format
Häftad (Paperback / softback)
Språk
Engelska
Antal sidor
96
Utgivningsdatum
2014-03-14
Förlag
LAP Lambert Academic Publishing
Medarbetare
Ahmed Sahar El Sayed / Aly Dalia Gamal El Din
Illustrationer
black & white illustrations
Dimensioner
229 x 152 x 6 mm
Vikt
150 g
Antal komponenter
1
Komponenter
Paperback
ISBN
9783659239847
NB-UVB Therapy vs Methotrexate on IL17and IL23 in psoriasis (häftad)

NB-UVB Therapy vs Methotrexate on IL17and IL23 in psoriasis

Häftad Engelska, 2014-03-14
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There is raised interest in the involvement of interleukin-(IL-)23/T-helper 17 cells (Th17) axis in the pathogenesis of psoriasis. Objectives. To compare the effect of narrow band ultraviolet B (NB-UVB) and methotrexate (MTX) therapy on serum levels of IL-17 and IL-23 in psoriatic patients. Methods. Thirty patients with severe plaque psoriasis were included: 15 patients received NB-UVB three times weekly (group I) and 15 patients received MTX 0.3mg/kg per week (group II), both for 8 weeks. Before and after treatment, serum levels of IL-17 and IL-23 were investigated by ELISA technique and psoriasis area and severity index (PASI) was calculated. Results. After treatment, all patients showed a reduction in their PASI score, IL-17 and IL-23 serum levels with a nonsignificant difference between both therapeutic modalities . A positive correlation was detected between the percent of reduction of IL-17, IL-23 and the percent of reduction of PASI score for patients receiving both treatments. Conclusion. Interleukin-17 and IL-23 serum level may serve as a potential biomarker for predicting the prognosis and therapeutic response of NB-UVB or MTX in treating psoriasis.
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